IHMT-PI3K-455 is a selective, orally active dual inhibitor of PI3Kγ and PI3Kδ, exhibiting IC50 values of 7.1 nM and 0.57 nM for each isoform, respectively. This compound effectively suppresses AKT phosphorylation, leading to documented inhibition of tumor growth through the recruitment and activation of CD8+ cytotoxic T cells. IHMT-PI3K-455 is primarily utilized in cancer research to explore its therapeutic potential and mechanisms in tumor biology.
IHMT-PI3K-455 is a selective, orally active dual inhibitor of PI3Kγ and PI3Kδ, exhibiting IC50 values of 7.1 nM and 0.57 nM for each isoform, respectively. This compound effectively suppresses AKT phosphorylation, leading to documented inhibition of tumor growth through the recruitment and activation of CD8+ cytotoxic T cells. IHMT-PI3K-455 is primarily utilized in cancer research to explore its therapeutic potential and mechanisms in tumor biology.
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