IKK-16

Catalog No.: A12836

IKK Inhibitor

IKK-16

IKK-16 Chemical Structure

CAS NO. 873225-46-8

IKK 16 is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.

Availability: In stock

Package Price Qty
10 mg
$80.00
25 mg
$150.00
50 mg
$220.00
100 mg
$350.00
10mM * 1mL in DMSO
$98.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Rulina AV, .et al. Distinct outcomes of CRL-Nedd8 pathway inhibition reveal cancer cell plasticity, Cell Death Dis, 2016, Dec 1;7(12):e2505 PMID: 27906189

Biological Activity

IKK 16 is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.
Targets
IKK2 (Cell-free assay) IKK complex (Cell-free assay) IKK1 (Cell-free assay)
40 nM70 nM200 nM
In vitro (25°C) DMSO 97 mg/mL (200.56 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.68 mL 103.38 mL 206.77 mL
0.5 mM 4.14 mL 20.68 mL 41.35 mL
1 mM 2.07 mL 10.34 mL 20.68 mL
5 mM 0.41 mL 2.07 mL 4.14 mL

*The above data is based on the productmolecular weight 483.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12836
Actions Inhibitor
M. Wt 483.63
Formula C28H29N5OS
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 873225-46-8
Synonyms IKK 16, IKK16
SMILES C1CCN(C1)C2CCN(CC2)C(=O)C3=CC=C(C=C3)NC4=NC=CC(=N4)C5=CC6=CC=CC=C6S5

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