Catalog No.: A12836

IKK Inhibitor


IKK-16 Chemical Structure

CAS NO. 873225-46-8

IKK 16 is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.

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10mM * 1mL in DMSO
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  • Rulina AV, .et al. Distinct outcomes of CRL-Nedd8 pathway inhibition reveal cancer cell plasticity, Cell Death Dis, 2016, Dec 1;7(12):e2505 PMID: 27906189

Biological Activity

IKK 16 is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.
IKK2 (Cell-free assay) IKK complex (Cell-free assay) IKK1 (Cell-free assay)
40 nM70 nM200 nM
In vitro (25°C) DMSO 95 mg/mL (196.42 mM)
Water Insoluble
Ethanol Insoluble
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.68 mL 103.38 mL 206.77 mL
0.5 mM 4.14 mL 20.68 mL 41.35 mL
1 mM 2.07 mL 10.34 mL 20.68 mL
5 mM 0.41 mL 2.07 mL 4.14 mL

*The above data is based on the productmolecular weight 483.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12836
Actions Inhibitor
CAS No. 873225-46-8
Formula C28H29N5OS
M. Wt 483.63
Purity >98%
Synonyms IKK 16, IKK16

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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