IM-12

Catalog No.: A14196

GSK-3β inhibitor

IM-12

IM-12 Chemical Structure

CAS NO. 1129669-05-1

IM-12 is a cell-permeable indolylmaleimide that acts as a Glycogen synthase kinase 3β (GSK-3β) inhibitor, activating downstream components of canonical Wnt signaling.

Availability: In stock

Package Price Qty
10 mg
$60.00
25 mg
$120.00
50 mg
$200.00
100 mg
$350.00
10mM * 1mL in DMSO
$82.00
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Biological Activity

IM-12 is a cell-permeable indolylmaleimide that acts as a Glycogen synthase kinase 3β (GSK-3β) inhibitor, activating downstream components of canonical Wnt signaling.
Targets
GSK-3β
53 nM
In vitro DMSO 72 mg/mL (190.77 mM)
Water Insoluble
Ethanol Warmed: 10 mg/mL (26.49 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.5 mL 132.48 mL 264.96 mL
0.5 mM 5.3 mL 26.5 mL 52.99 mL
1 mM 2.65 mL 13.25 mL 26.5 mL
5 mM 0.53 mL 2.65 mL 5.3 mL

*The above data is based on the productmolecular weight 377.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A14196
Actions Inhibitor
CAS No. 1129669-05-1
Formula C22H20FN3O2
M. Wt 377.41
Purity >98%
Synonyms IM12, IM 12
SMILES CC1=C(C2=CC=CC=C2N1)C3=C(C(=O)N(C3=O)C)NCCC4=CC=C(C=C4)F
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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