Imipramine-d4 is a deuterated form of Imipramine, a tricyclic antidepressant that primarily acts as a serotonin transporter inhibitor with an IC50 of 32 nM. This compound demonstrates significant biological activities, including inhibition of Fascin1, which contributes to its antitumor effects. Additionally, Imipramine has been shown to stimulate autophagy in U-87MG glioma cells and induce apoptosis in HL-60 cells. Its neuroprotective and immunomodulatory properties make it a valuable reagent for research in cancer biology and neuropharmacology.
Imipramine-d4 is a deuterated form of Imipramine, a tricyclic antidepressant that primarily acts as a serotonin transporter inhibitor with an IC50 of 32 nM. This compound demonstrates significant biological activities, including inhibition of Fascin1, which contributes to its antitumor effects. Additionally, Imipramine has been shown to stimulate autophagy in U-87MG glioma cells and induce apoptosis in HL-60 cells. Its neuroprotective and immunomodulatory properties make it a valuable reagent for research in cancer biology and neuropharmacology.
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