Catalog No.
Product Name
Application
Product Information
Citations
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Anti-inflammatory Agent
HMR-4011A is a chemically modified derivative of Contignasterol, functioning as an orally active anti-inflammatory agent. It exhibits significant efficacy in reducing inflammation and has potential applications in respiratory research, particularly in the context of asthma. HMR-4011A offers valuable insights for studies focused on inflammatory pathways and therapeutic interventions. -
Anti-Inflammatory Agent
Mofebutazone is a monophenyl analogue of Phenylbutazone, functioning primarily as an anti-inflammatory agent. It exhibits potent anti-inflammatory activity and is utilized in research related to asthma and other inflammatory conditions. Its oral bioavailability makes it a valuable tool for studying the therapeutic effects of anti-inflammatory compounds in various biological models. -
Anti-inflammatory Agent
Stemospironine is an alkaloid derived from plants of the genus Hyacinth, functioning primarily as an anti-inflammatory agent. It exhibits significant biological activity as a cough suppressant while also serving as a valuable tool for investigating various inflammatory conditions. Its potential applications in research include exploring mechanisms of inflammation and evaluating therapeutic strategies for related diseases. -
Antiinflammatory Agent
Sodium gualenate hydrate, a sodium salt derivative of guaiazulene, primarily acts as an anti-inflammatory agent. It exhibits significant biological activity in promoting wound healing and is commonly utilized in research related to gastrointestinal conditions such as duodenal ulcers, gastric ulcers, and gastritis. Its potential therapeutic applications in reducing inflammation make it a valuable reagent for studies in inflammatory disease pathways. -
Anti-Inflammatory Agent
Mofebutazone sodium is a monophenyl analogue of Phenylbutazone that functions as an orally active anti-inflammatory agent. This compound exhibits significant anti-inflammatory properties and is primarily utilized in asthma research to investigate its effects on respiratory conditions. Its mechanism of action involves the inhibition of cyclooxygenase enzymes, leading to decreased production of pro-inflammatory mediators. -
Anti-inflammatory Agent
NIP 502 is a pyridazinone derivative that acts as an anti-inflammatory agent targeting immune response pathways. This compound exhibits significant anti-inflammatory and immunomodulatory properties, making it valuable for investigating conditions such as asthma. Its efficacy in modulating inflammation positions NIP 502 as a critical reagent for research focused on respiratory disorders and related therapeutic developments. -
Anti-inflammatory Agent
Epmedin C is an orally active anti-inflammatory agent and immunomodulator that targets multiple key proteins, including UCP1, Caspase-1, CDK2, and Keap1. This compound effectively inhibits epithelial cell proliferation by disrupting the CDK2/Cyclin E complex, while also upregulating Nrf2 expression, reducing reactive oxygen species levels, and inhibiting the secretion of pro-inflammatory cytokines. Through these mechanisms, Epmedin C aids in restoring antibody production and alleviating tissue damage, making it relevant for research on conditions such as obesity, immunotoxicity induced by Deoxynivalenol, and mammary hyperplasia. -
Anti-inflammatory Agent
Saikosaponin A is an anti-inflammatory agent primarily derived from Bupleurum chinense. It effectively regulates lipid metabolism and promotes cholesterol efflux, making it relevant in early atherosclerosis research. Furthermore, Saikosaponin A acts as a potential agonist of peroxisome proliferator-activated receptor γ (PPAR-γ), significantly enhancing its expression. This compound is particularly useful in studies related to hyperlipidemic pancreatitis. -
Anti-inflammatory Agent
Physalin L is an anti-inflammatory agent that inhibits lipopolysaccharide (LPS)-induced nitric oxide (NO) production in macrophages, achieving an average inhibitory rate of 70.97%. This compound is valuable for research focused on inflammation pathways and can be utilized to investigate its potential therapeutic effects in various inflammatory conditions. -
Anti-inflammatory Agent
Chikusetsusaponin IVa is an orally active anti-inflammatory agent that targets YAP, demonstrating a binding affinity with a KD value of 0.388 mM. This compound effectively reduces the expression of inflammatory mediators such as IL-6, IL-10, and COX-2, while modulating nitric oxide production and promoting reactive oxygen species generation. Additionally, Chikusetsusaponin IVa induces apoptosis, inhibits MAPK and TAZ signaling pathways, and regulates Nrf2 and JAK/STAT pathways. It exhibits potential as an anti-H9N2 avian influenza virus agent and demonstrates anti-cancer properties, along with hepatoprotective and osteoprotective effects, making it a valuable tool for research in inflammation and cancer biology. -
Anti-inflammatory Agent
Praeruptorin A is an anti-inflammatory compound derived from Peucedanum praeruptorum. It demonstrates significant anti-inflammatory activity by inhibiting NF-κB activation, which is crucial for mediating inflammatory responses. This compound is valuable in research applications focused on inflammation-related signaling pathways and the development of anti-inflammatory therapies. -
Antiinflammatory Agent
Sodium gualenate is a hydrophilic derivative of guaiazulene that functions as an anti-inflammatory agent. It exhibits significant anti-inflammatory and wound-healing properties, making it useful in the treatment of conditions such as duodenal ulcers, gastric ulcers, and gastritis. This compound is valuable for research focused on gastrointestinal health and the modulation of inflammatory responses. -
Anti-inflammatory Compound
Methyl 2-acetoxybenzoate, also known as methyl acetylsalicylate, serves as a prodrug that exerts anti-inflammatory effects. Upon chemical or enzymatic hydrolysis, it converts to methyl 2-hydroxybenzoate, which is known for its analgesic properties. This compound is applicable in research pertaining to inflammatory diseases and can be utilized as an analgesic agent in topical formulations such as liniments. -
Anti-inflammatory Agent
6α-Fluoroprednisolone is an anti-inflammatory agent that serves as an internal standard for the analysis of methylprednisolone, prednisolone, and prednisone. This compound is essential for research applications related to congenital adrenal virilism and Addison's disease, aiding in the understanding of adrenal function and corticosteroid therapy. It is an invaluable tool for studies focused on steroid hormone action and metabolic regulation. -
Anti-Inflammatory Corticosteroid
Paramethasone is an anti-inflammatory corticosteroid that targets glucocorticoid receptors. It is known for its ability to reduce inflammation and modulate immune responses, making it valuable in the treatment of various inflammatory and autoimmune conditions. This compound is commonly utilized in research to investigate corticosteroid mechanisms and therapeutic applications in disorders such as asthma, arthritis, and other inflammatory diseases. -
Anti-inflammatory and Protein-Binding Inhibitor
4-Acetylaminoantipyrine is a derivative of antipyrine that functions primarily as an anti-inflammatory agent and a protein-binding inhibitor. It acts as a PGE2-dependent blocker and inhibits cyclooxygenase (COX), thereby modulating inflammatory pathways. Additionally, 4-acetylaminoantipyrine has the capability to inhibit Cu/Zn superoxide dismutase (Cu/ZnSOD) and can spontaneously bind with bovine serum albumin (BSA), resulting in conformational changes. This compound is valuable for research applications in inflammation and protein interaction studies. -
Pro-inflammatory Mediator Inhibitor
Heparin disaccharide III-S (trisodium) is a heparin-derived disaccharide that serves as a pro-inflammatory mediator inhibitor. It effectively inhibits the spontaneous secretion of interleukin-8 (IL-8) and interleukin-1 beta (IL-1β) in intestinal epithelial cells by acting at the post-translational level without affecting mRNA or intracellular mediator concentrations. This compound is useful for research on inflammatory responses and the regulation of cytokine secretion in intestinal models. -
Pro-inflammatory Mediator Inhibitor
Heparin disaccharide I-H (trisodium) is a heparin-derived disaccharide that acts as a pro-inflammatory mediator inhibitor. This compound effectively blocks the spontaneous secretion of IL-8 and IL-1β in intestinal epithelial cells at the post-translational level, while leaving mRNA expression levels and intracellular contents unaffected. Demonstrating dose-dependent anti-inflammatory activity, Heparin disaccharide I-H (trisodium) is valuable for research applications targeting intestinal inflammation and associated signaling pathways. -
Anti-inflammatory/Analgesic Agent
Nitraquazone is an anti-inflammatory and analgesic agent that inhibits phosphodiesterase, leading to increased intracellular levels of cyclic adenosine monophosphate (cAMP). This mechanism underlies its potential use in research focused on inflammation and pain management. Nitraquazone serves as a valuable tool in the investigation of anti-inflammatory pathways and analgesic effects in various biological contexts. -
Anti-inflammatory/tumor Agent
Hesperetin triacetate is a compound known for its anti-inflammatory and anti-tumor properties. It exerts its effects by inhibiting the denaturation of bovine serum albumin in vitro and reducing carrageenan-induced paw swelling in mouse models in vivo. Additionally, Hesperetin triacetate demonstrates anti-proliferative activity against breast cancer cells, inducing DNA degradation and apoptosis. This compound is suitable for research focused on breast cancer and inflammation mechanisms. -
Anti-inflammatory Agent
Lonchocarpic acid acts as an anti-inflammatory agent, targeting pathways involved in neuroinflammation. It has demonstrated efficacy in models of LPS- or poly(I:C)-induced neuroinflammation, suggesting potential applications in investigating neuroinflammatory conditions. This compound is useful for researchers exploring the molecular mechanisms of inflammation and developing therapeutic strategies for related disorders. -
Anti-inflammatory agent
Sanggenon B is an anti-inflammatory agent that exhibits inhibitory effects on nitric oxide (NO) production in LPS-stimulated RAW264.7 macrophage cells. This compound, extracted from mulberry trees, serves as a valuable tool in research applications focused on understanding and mitigating inflammatory processes. Its biological activity positions it as a potential candidate for further exploration in therapeutic contexts related to inflammation. -
Anti-Inflammatory Agent
Cucurbitadienol is a natural compound primarily known for its anti-inflammatory properties. Isolated from the seeds of Trichosanthes kirilowii, this tetracyclic terpene has been shown to modulate inflammatory pathways. Its biological activity makes it a valuable tool in research focused on understanding and developing treatments for inflammatory diseases. -
Anti-inflammatory Agent
Alpinenone is a sesquiterpene compound with anti-inflammatory properties. It acts by inhibiting the overproduction of nitric oxide (NO), thereby reducing inflammation. Alpinenone is suitable for research applications focused on inflammation-related diseases, as well as gastrointestinal and urinary system disorders. -
Anti-Inflammatory Agent
Prinomide triethanolamine is an orally available nonsteroidal anti-inflammatory agent targeting pathways involved in inflammation. It exhibits significant anti-inflammatory properties and is utilized in research focused on inflammatory diseases, including rheumatoid arthritis. This reagent provides valuable insights into the mechanisms of inflammation and the potential therapeutic effects of anti-inflammatory compounds. -
Anti-Inflammatory Agent
Anti-inflammatory agent 36 is a potent anti-inflammatory compound that selectively inhibits lipopolysaccharide (LPS)-induced macrophage activation. This mechanism aids in modulating inflammatory responses, making it a valuable tool for studying inflammatory pathways and potential therapeutic interventions. Its application is pivotal in researching conditions characterized by excessive inflammation, contributing to a better understanding of inflammatory diseases. -
Anti-inflammatory Agent
EVT‑401 is an anti-inflammatory agent that modulates immune responses by inhibiting key inflammatory pathways. It demonstrates significant pharmacological effects in vivo and is valuable for studying various inflammatory conditions. EVT‑401 is a potent tool for research focused on understanding the mechanisms of inflammation and potential therapeutic interventions. -
Anti-inflammatory/antioxidant
S-Carboxymethyl-L-cysteine L-lysine monohydrate is a mucosal active compound that demonstrates notable anti-inflammatory and antioxidant properties. This reagent is primarily utilized in research related to chronic obstructive pulmonary disease (COPD), where it may help in elucidating the underlying mechanisms of inflammation and oxidative stress. Its unique profile makes it valuable for studies aimed at developing therapeutic strategies for respiratory conditions. -
Anti-inflammatory Agent
Zidometacin is a nonsteroidal anti-inflammatory agent that primarily targets prostaglandin synthesis, effectively reducing inflammation with a diminished risk of gastrointestinal toxicity. It exhibits notable antinociceptive and antipyretic properties, demonstrating low ulcerogenic potential in rat models. Zidometacin is applicable in research focused on analgesia and osteoarthritis, contributing valuable insights into pain management and inflammatory processes. -
Anti-inflammatory Agent
PH-46A is an indane dimer that operates as an anti-inflammatory agent. It has demonstrated the ability to reduce histological damage and lower serum amyloid A (SAA) levels in murine models of colitis. This compound is valuable for research applications focused on inflammatory diseases and therapeutic intervention strategies. -
Anti-inflammatory Agent
5,7,5′-Trihydroxy-3′,4′-dimethoxyflavonol-3-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside functions as an anti-inflammatory agent and belongs to the flavonol glycoside class. This compound, isolated from Ginkgo biloba leaves, demonstrates significant antioxidative and cardioprotective properties. Its application extends to investigating mechanisms underlying inflammation and cardiac injury, making it a valuable reagent for biochemical and pharmacological research. -
Anti-inflammatory Agent
Chinoin 127 is a non-anesthetic analgesic agent that exhibits significant anti-inflammatory properties. Demonstrated to provide potent analgesic effects in various models, including the hot plate test, Randall-Selitto test, and torsion test, Chinoin 127 is valuable for research applications aimed at understanding pain mechanisms and developing therapies for inflammatory conditions. -
Anti-inflammatory Agent
Diacetyl boldine is an anti-inflammatory agent known for its soothing and moisturizing properties. This compound is investigated for its potential effects on skin disorders, particularly melasma and lentigo senilis. Its biological activity makes it a valuable reagent for research focused on dermatological applications and skin health. -
Anti-Inflammatory Agent
Prinomide tromethamine is an orally available nonsteroidal anti-inflammatory agent that targets inflammatory pathways. It exhibits significant biological activity by reducing inflammation and alleviating symptoms associated with conditions such as rheumatoid arthritis. This compound is valuable for research focused on understanding inflammatory mechanisms and developing therapeutic strategies for related diseases. -
Anti-Inflammatory Agent
Polyporoid C is an ergostane-type ecdysteroid with strong anti-inflammatory properties. It has been demonstrated to reduce inflammation in vivo, making it a valuable tool for investigating inflammatory pathways. This compound is suitable for research applications focused on inflammation modulation and therapeutic mechanisms. -
Antiinflammatory Agent
Etofesalamide is a nonsteroidal anti-inflammatory agent that targets inflammatory pathways to modulate immune responses. It exhibits significant biological activity through its major phase II metabolites, including glucoside and riboside conjugates, such as etofesalamide-2-glucuronide in filamentous fungi. This compound is applicable in research related to allergic and autoimmune skin disorders, including acne, psoriasis, and contact dermatitis. -
Anti-inflammatory Agent
Zizyvoside I is a bioactive compound derived from Dioscorea septemloba, known for its anti-inflammatory properties. This compound has demonstrated the ability to modulate inflammatory responses, making it a valuable tool in research focused on inflammatory diseases. Zizyvoside I can be utilized in studies investigating the underlying mechanisms of inflammation and the development of therapeutic strategies. -
Anti-inflammatory Agent
DD-3305 is an anti-inflammatory agent that significantly reduces both acute and chronic inflammation. In models of carrageenan-induced inflammation in rats, DD-3305 demonstrated comparable efficacy to indomethacin, effectively abating inflammatory responses and allergy-related symptoms. This compound is a valuable tool for research applications focused on inflammation pathways and potential therapeutic interventions. -
Non-steroidal Anti-inflammatory Agent
Lotifazole is a non-steroidal anti-inflammatory agent that specifically inhibits delayed-type hypersensitivity without relying on the prostaglandin synthesis inhibition pathway at low doses. It demonstrates significant efficacy in reducing paw edema induced by carrageenan in rats, alleviating erythema caused by ultraviolet radiation in guinea pigs, and mitigating pleurisy at high doses. Lotifazole is valuable for research into T-cell-mediated diseases, providing insights into potential therapeutic strategies. -
Anti-Inflammatory Agent
Genipin 1-β-D-gentiobioside is an iridoid glycoside extracted from Gardenia jasminoides, exhibiting strong anti-inflammatory properties. This compound demonstrates hepatoprotective and antioxidant activities, making it valuable for research on liver health and inflammation-related pathways. Its antithrombotic effects also highlight its potential in cardiovascular studies. -
Anti-inflammatory Agent
Delmetacin is an anti-inflammatory agent that primarily targets cyclooxygenase enzymes, thereby inhibiting prostaglandin synthesis. This mechanism results in the reduction of inflammation and pain. Delmetacin is utilized in various research applications focused on inflammatory diseases and pain management, making it a valuable tool for understanding inflammatory pathways and developing new therapeutic strategies. -
Anti-Inflammatory Agent
Butin is a biologically active flavonoid primarily targeting anti-inflammatory pathways. Isolated from the heartwood of Dalbergia odorifera, Butin exhibits strong antioxidant and antiplatelet properties. It has been shown to significantly alleviate myocardial infarction symptoms, enhance cardiac function, and prevent diabetes-induced oxidative damage in the heart in rat models, making it a valuable compound for cardiovascular and metabolic research applications. -
Anti-Inflammatory Agent
11-O-Galloylbergenin is an anti-inflammatory agent derived from the ethanolic extract of Mallotus philippinensis. This compound exhibits significant analgesic and anti-inflammatory properties, making it a valuable tool for research related to pain management and inflammatory conditions. Its potential utility in therapeutic applications underscores its importance in pharmacological studies. -
Antiinflammatory Agent
Fenclozine dimaleate is a non-steroidal anti-inflammatory agent that primarily targets inflammatory pathways. It exhibits significant anti-inflammatory activity and is utilized in research to investigate various inflammatory conditions and their underlying mechanisms. Its potential applications include studying pain relief and reducing inflammation in both in vitro and in vivo models. -
Anti-Neuroinflammatory Agent
Fendleryl B is an anti-neuroinflammatory agent derived from the edible mushroom Gambas. This compound demonstrates significant potential in modulating neuroinflammatory responses, making it valuable for studying neurological diseases and related pathologies. Its ability to influence neuroinflammation positions it as a promising candidate for research in neurodegenerative disorders. -
anti-inflammatory agent
Lofemizole is a non-steroidal anti-inflammatory agent that inhibits the activity of cyclooxygenase enzymes, leading to a reduction in prostaglandin synthesis. This compound exhibits significant anti-inflammatory properties, making it valuable in the study of inflammatory diseases. Lofemizole can be utilized in research to explore therapeutic strategies for conditions characterized by chronic inflammation. -
Anti-inflammatory Compound
Triptoquinone H is an anti-inflammatory compound derived from the traditional Chinese medicine Tripterygium hypoglaucu. It exhibits significant cytotoxic, immunomodulatory, and anti-inflammatory activities, making it a valuable tool for studying cancer and inflammatory diseases. Researchers can utilize Triptoquinone H to explore its therapeutic potential and mechanisms in various biological contexts. -
Nonsteroidal Anti-inflammatory Drug
Clofenamic acid, a nonsteroidal anti-inflammatory drug, primarily targets cyclooxygenase enzymes (COX-1 and COX-2) to inhibit prostaglandin synthesis. It exhibits significant anti-inflammatory and analgesic properties, making it a useful tool for studying inflammatory processes. Clofenamic acid is particularly relevant in research related to rheumatoid arthritis and other inflammatory disorders. -
Anti-Inflammatory Agent
1-beta-D-Arabinofuranosyluracil is an anti-inflammatory agent derived from the Caribbean sponge Tectitethya crypta. This compound exhibits a range of biological activities, including anti-inflammatory effects, analgesic properties, and vasodilation. Additionally, it has been shown to inhibit the proliferation of mouse lymphoma cells, making it a valuable reagent for research in cellular biology and inflammation studies. -
Anti-Inflammatory Agent
Broperamole is an anti-inflammatory agent that acts primarily by modulating inflammatory pathways. It exhibits both systemic and topical anti-inflammatory activity, making it a valuable tool for the investigation of inflammation-related disorders. This compound can be utilized in research applications focused on pain management and therapeutic interventions for inflammatory conditions.
