Catalog No.
Product Name
Application
Product Information
Citations
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Anti-inflammatory Agent
Isonixin is a non-steroidal anti-inflammatory agent that targets cyclooxygenase enzymes. Its primary biological activity involves the inhibition of prostaglandin synthesis, leading to reduced inflammation and pain. Isonixin is widely used in research applications focused on elucidating mechanisms of pain and inflammatory responses, making it a valuable tool for scientific studies in these areas. -
Anti-inflammatory Agent
Anti-inflammatory agent 8 is a tilomisole-based benzimidazothiazole derivative targeting the COX-2 enzyme with enhanced selectivity over COX-1, exhibiting an IC50 of 0.09 nM. This compound demonstrates significant anti-inflammatory activity, making it a valuable tool for research into mechanisms of inflammation and related pathophysiological conditions. Its oral bioavailability supports its utility in in vivo studies. -
Anti-inflammatory Agent
Cinmetacin is an orally active anti-inflammatory agent that selectively targets cyclooxygenase (COX). Its mechanism of action involves the inhibition of prostaglandin synthesis, making it effective in modulating inflammatory responses. This compound shows promise for research applications related to inflammatory diseases, including arthritis, by providing insights into COX-mediated pathways and potential therapeutic interventions. -
Anti-inflammatory Agent
Buddlejasaponin IV is an anti-inflammatory agent that demonstrates cytotoxic effects on cancer cells. This compound modulates inflammatory pathways, making it a valuable tool in research focused on inflammation-related diseases and cancer therapies. Its biological activity supports investigations into therapeutic strategies for managing inflammation and tumorigenesis. -
Nonsteroidal Anti-Inflammatory Drug
Miroprofen is an orally active nonsteroidal anti-inflammatory drug (NSAID) that functions primarily as an analgesic. It demonstrates significant anti-inflammatory and analgesic properties, along with anti-platelet activity. Miroprofen is utilized in research applications aimed at understanding pain mechanisms and the role of inflammation in various disease models. -
Anti-inflammatory Agent
Anti-inflammatory agent 10 is a tilomisole-based benzimidazothiazole derivative designed to selectively inhibit the COX-2 enzyme over COX-1. This selectivity contributes to its anti-inflammatory properties, making it a valuable tool for research on inflammation-related pathways. Anti-inflammatory agent 10 is orally active, facilitating in vivo studies targeting inflammation and related diseases. -
Anti-inflammatory Agent
(S)-Otenaproxesul is an anti-inflammatory agent that primarily targets cyclooxygenase enzymes. It has demonstrated potential protective effects against gastric damage, making it a valuable substance for research into gastrointestinal health. This compound is suitable for studies investigating inflammation-related conditions and the development of novel therapeutic strategies. -
Nonsteroidal Anti-inflammatory Agent
Oxindanac is a nonsteroidal anti-inflammatory agent that primarily targets the inhibition of serum thromboxane B2 (TxB2) production. This compound effectively reduces edema and demonstrates significant analgesic properties. Oxindanac is utilized in research to study inflammation and pain management pathways, contributing valuable insights into therapeutic strategies for various inflammatory conditions. -
Analgesic Antiinflammatory Agent
Tomoxiprole is an analgesic anti-inflammatory agent that selectively inhibits cyclooxygenase-2, with an IC50 value of 7 nM. Its precise inhibition of this enzyme leads to reduced inflammatory responses and pain relief. Tomoxiprole is primarily utilized in research focused on pain management and the modulation of inflammatory pathways. -
Anti-inflammatory Agent
Anti-inflammatory agent 9 is a tilomisole-based benzimidazothiazole derivative that selectively inhibits the cyclooxygenase-2 (COX-2) enzyme over cyclooxygenase-1 (COX-1). This compound demonstrates significant anti-inflammatory activity, making it a valuable tool in the study of inflammation-related pathways and therapeutic interventions. Its oral bioavailability facilitates in vivo research applications, contributing to investigations in both pharmacology and medicinal chemistry. -
Anti-inflammatory Agent
MBL-1 is an orally active anti-inflammatory agent that targets the hCOX-2 protein, demonstrating an IC50 of 5.77 μM. This compound effectively reduces the production of key pro-inflammatory mediators, including nitrogen oxide (NO), reactive oxygen species (ROS), IL-1β, and IL-18, by inhibiting the MAPK/NF-κB and NLRP3 signaling pathways. MBL-1 has shown protective effects against dextran sulfate sodium (DSS)-induced colitis, making it a valuable tool for research into ulcerative colitis and related inflammatory conditions. -
Anti-inflammatory Agent
NCX 2121 (NO-indomethacin) is an anti-inflammatory agent that acts primarily by inhibiting the production of pro-inflammatory mediators. It effectively inhibits the growth of PaCa-2 pancreatic cancer cells, exhibiting an IC50 value of 82 μM. This compound is utilized in research focusing on inflammation-related pathways and cancer biology. -
Anti-Inflammatory Agent
M-5011 is a potent orally active anti-inflammatory agent that targets the modulation of inflammatory pathways. This compound exhibits significant antinociceptive effects, demonstrated by its inhibition of kaolin-induced writhing in experimental models. Additionally, M-5011 effectively reduces peritoneal levels of 6-keto-PGF1 alpha while exhibiting low ulcerogenic potential. Its pharmacological profile includes notable anti-inflammatory, anti-pyretic, and analgesic properties, making it valuable for research into pain and inflammation mechanisms. -
Anti-inflammatory Effect, Antioxidant Activity
Prifelone is a di-tert-butylphenol known for its anti-inflammatory effects and antioxidant activity. It demonstrates the ability to inhibit guinea pig lung oxygenase and bovine seminal vesicle cyclooxygenase, making it a valuable tool for research into inflammatory processes and oxidative stress. Its applications include investigations into inflammation-related diseases and the development of therapeutic strategies targeting these pathways. -
Anti-Inflammatory Agent
BF389 is an orally active anti-inflammatory agent that functions as an inhibitor of cyclooxygenase (COX) and 5-lipoxygenase (5-LOX), demonstrating IC50 values of 4 µg/mL for COX-1 and 8 µg/mL for COX-2. This compound exhibits significant anti-inflammatory activity making it suitable for research in arthritis and other inflammatory conditions. BF389 may serve as a valuable tool in the investigation of therapeutic strategies targeting inflammation-related pathways. -
Non-steroidal Anti-inflammatory Reagent
Piketoprofen is a non-steroidal anti-inflammatory agent primarily targeting the cyclooxygenase-2 (COX-2) enzyme. It exhibits significant analgesic and anti-inflammatory activity, making it suitable for research applications related to soft tissue rheumatism. Piketoprofen-amide, a prodrug form, offers enhanced delivery and efficacy in COX-2 inhibition, providing valuable insights into therapeutic strategies for inflammatory conditions. -
Non-steroidal Anti-inflammatory Agent
Ketoprofen sodium is a non-steroidal anti-inflammatory agent that primarily targets cyclooxygenase (COX) enzymes, demonstrating inhibitory activity with IC50 values of 2 nM for COX-1 and 26 nM for COX-2. This compound is valuable in the study of inflammatory processes, immunological responses, and metabolic disorders, including obesity. Its potent anti-inflammatory properties make it a relevant tool in research aimed at understanding and mitigating these conditions. -
Anti-inflammatory Agent
4-MDM (4-Methoxydiphenylmethane) is an orally active anti-inflammatory agent that selectively enhances the activity of the enzyme leukotriene A4 hydrolase (LTA4H) by promoting its aminopeptidase function. This modulation reduces neutrophil recruitment in the lungs through the improved degradation of proline-glycine-proline, leading to a decrease in inflammation. Importantly, 4-MDM does not influence the epoxy-hydrolase activity of LTA4H. This compound is suitable for studies focusing on lung diseases and related inflammatory conditions. -
Anti-inflammatory Agent, Aminopeptidase Inhibitor
2-(2'-Pyridyl)benzimidazole is an effective anti-inflammatory agent and a potent inhibitor of methionine aminopeptidase in Escherichia coli. This compound exhibits tridentate ligand properties, capable of forming stable complexes with various transition metal ions. Its applications extend to biochemical research focused on inflammatory processes and amino acid metabolism, making it a valuable reagent for studies in these areas. -
Anti-Inflammatory Agent
Methylprednisolone aceponate is a glucocorticoid with a specific mechanism of action as a selective glucocorticoid receptor ligand, primarily functioning as an anti-inflammatory agent. It exhibits weak systemic effects, making it particularly useful in the treatment of localized inflammatory conditions. This compound is valuable for research applications targeting eczema and other inflammatory skin disorders, aiding in the understanding of their pathophysiology and potential treatments. -
Anti-inflammatory Agent
Isoflupredone acetate is a corticosteroid with potent anti-inflammatory properties. It modulates inflammatory responses and is utilized in research related to ketosis, musculoskeletal disorders, hypersensitivity, and various inflammatory diseases in animals such as cows, horses, and pigs. This compound serves as a valuable tool for studying the mechanisms of inflammation and therapeutic interventions in veterinary medicine. -
Anti-inflammatory Agent
Mazipredone free base is a glucocorticoid derivative that functions primarily as an anti-inflammatory and anti-allergic agent. It exhibits significant biological activity in reducing inflammation and managing allergic responses. This compound is particularly useful in research applications focused on inflammation-related conditions and therapeutic interventions targeting the immune response. Mazipredone free base is sensitive to oxidation and is affected by both acidic and basic environments. -
Anti-inflammatory agent
Fluocortolone is an orally active anti-inflammatory agent targeting the modulation of inflammatory responses. It is known to effectively reduce plasma fibrinogen levels and demonstrates significant efficacy in alleviating Mycobacterium butyricum-induced foot edema in rat models of adjuvanted joint inflammation, with effective dosing in the range of 3-12 mg/kg. This compound is valuable for studies related to inflammation and joint diseases. -
Anti-inflammatory Agent
Rimexolone is a glucocorticoid steroid that functions primarily as an anti-inflammatory agent. It exhibits potent anti-inflammatory properties and is employed in the management of ocular inflammation. Its formulation as a 1% ophthalmic suspension makes it suitable for targeted treatment in various inflammatory conditions affecting the eye. -
Anti-Inflammatory agent
Fluocortin butyl ester is a topical corticosteroid with anti-inflammatory properties, demonstrating minimal systemic corticosteroid activity upon application. It has shown efficacy and good tolerance in managing symptoms of perennial rhinitis, making it a valuable reagent for research focused on inflammatory responses and related conditions. -
Anti-inflammatory Agent
Prednisolone metazoate sodium is an anti-inflammatory agent primarily used in the study of inflammatory bowel disease, ulcerative colitis, and gastrointestinal disorders. This compound exerts its biological activity by modulating the immune response and reducing inflammation, making it a valuable tool in research focused on inflammatory conditions of the gastrointestinal tract. -
Anti-Inflammatory Agent
Phenyl β-D-glucopyranoside is an anti-inflammatory agent derived from Phellodendron amurense. It exerts its biological activity by inhibiting nitric oxide (NO) production, along with the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Additionally, Phenyl β-D-glucopyranoside prevents the nuclear translocation of nuclear factor kappa B (NF-κB), leading to the reduced expression of pro-inflammatory cytokines and associated genes. This compound is valuable for researchers studying inflammation and related signaling pathways. -
Anti-inflammatory Agent
Fentiazac is an orally active non-steroidal anti-inflammatory agent and alkanoic acid derivative. It exhibits analgesic, antipyretic, and platelet anti-aggregation properties, making it a valuable tool for investigating inflammatory diseases. Research applications include studies related to rheumatoid arthritis, osteoarthritis, and tendinitis. -
Anti-inflammatory Agent
Vedaprofen is a COX-1 selective nonsteroidal anti-inflammatory agent (NSAID) that exerts its effects by inhibiting serum TxB2 and exudate PGE2 production. Additionally, it demonstrates the ability to inhibit the sliding clamp (SC) of Escherichia coli (E. coli) with an IC50 of 222 μM. This dual action makes Vedaprofen valuable for research applications focused on inflammation and bacterial mechanisms. -
Nonsteroidal Anti-inflammatory Agent
Flobufen is a nonsteroidal anti-inflammatory agent that functions primarily as an inhibitor of cyclooxygenase (COX) and 5-lipoxygenase (5-LOX). It has been shown to inhibit alloantigen-driven cellular immune responses while enhancing phagocytosis in peritoneal cells. Flobufen is utilized in research focused on immunopathological disorders and demonstrates potential therapeutic effects in conditions such as rheumatoid arthritis. -
Anti-Inflammatory Agent
Paranyline hydrochloride is an anti-inflammatory agent that exhibits topical antiallodynic activity. It is primarily utilized in research exploring pain modulation and inflammation pathways. This compound is valuable for studying the mechanisms underlying chronic pain and developing therapeutic strategies for inflammatory conditions. -
Anti-inflammatory Agent
3-Aminobenzoic acid (3-ABA) is an orally active anti-inflammatory agent that targets tight junction regulatory pathways in intestinal epithelial cells. This compound enhances intestinal barrier integrity and reduces epithelial permeability, thereby improving intestinal inflammation. 3-Aminobenzoic acid is valuable in research focused on gut health, and its analogs can serve as γ-aminobutyric acid transaminase (GABA-AT) inhibitors, demonstrating potential anticonvulsant effects. -
Anti-inflammatory Agent
α-Viniferin is an anti-inflammatory compound derived from the root of Caragana chamlagu. It demonstrates significant potential in modulating inflammatory pathways, making it valuable for research into inflammatory diseases. Its biological activity suggests applications in both pharmacological studies and the development of therapeutic agents targeting inflammation-related conditions. -
Antidiabetic/Anti-inflammatory Agent
9-PAHPA is a fatty acid ester of hydroxy fatty acids (FAHFA) that exhibits significant antidiabetic and anti-inflammatory properties. This compound modulates metabolic processes and inflammation pathways, making it a valuable tool for research in metabolic disorders and chronic inflammatory conditions. Its unique mechanism as an endogenous lipid positions it as a promising candidate for studies focused on therapeutic interventions in diabetes and related inflammatory diseases. -
Anti-Inflammatory reagent
9-OAHSA is a fatty acid ester of hydroxy fatty acids (FAHFAs) known for its anti-inflammatory properties. It exerts its effects by inhibiting cytokine production, notably reducing the expression of IL-1β and IL-6. Additionally, 9-OAHSA functions as a protective agent, preventing apoptotic cell death in colon carcinoma cells, making it a valuable tool for research in inflammation and cancer biology. -
Anti-Inflammatory Agent
9-POHSA is a fatty acid ester of hydroxy fatty acids (FAHFAs) that functions as an anti-inflammatory agent. It exhibits significant anti-inflammatory activity by inhibiting cytokine production, particularly reducing the expression of IL-1β and IL-6. This compound is relevant for research into inflammatory pathways and potential therapeutic applications in inflammatory diseases. -
Anti-inflammatory Agent
Lipoxin B4 (LXB4) is an anti-inflammatory agent derived from the metabolism of arachidonic acid. It effectively reduces leukocyte infiltration and mucus secretion in the nasal mucosa while inhibiting mast cell and eosinophil degranulation in the upper airway. Additionally, LXB4 mitigates airway inflammation, mucus metaplasia, and hyper-responsiveness in the lower airway, demonstrating significant mucosal protective actions. Its properties make it a valuable tool for research into allergic inflammation in the upper and lower respiratory tracts. -
Anti-inflammatory Agent
17(R)-Resolvin D1 methyl ester serves as a potent anti-inflammatory agent, derived from Aspirin-induced Resolvin D1. This compound is known to regulate the transendothelial migration of human polymorphonuclear leukocytes, displaying significant efficacy with an EC50 of approximately 30 nM for inhibiting neutrophil migration. Its stability as the 17R-trihydroxy-4Z form enhances its utility in inflammation research and therapeutic applications. -
Non-Steroidal Antiinflammatory Agent
Diflumidone sodium is a non-steroidal anti-inflammatory agent that primarily targets the COX enzyme pathway. This compound exhibits potent anti-inflammatory activity and is utilized in various research applications aimed at understanding inflammatory processes and developing therapeutic strategies for inflammatory diseases. Its ability to modulate inflammation makes it a valuable tool in pharmacological studies and drug development. -
Anti-inflammatory Agent
Tixocortol pivalate is a corticosteroid that functions primarily as an anti-inflammatory agent. It exhibits significant anti-inflammatory properties, making it useful in the research of inflammatory conditions and disorders. This compound is typically employed in studies aimed at understanding the mechanisms of corticosteroids in therapeutic applications. -
Anti-Inflammatory Agent
3-Aminoisobutyric acid sodium salt acts as an anti-inflammatory agent through its antioxidant properties. It enhances the expression of brown adipocyte-specific genes within white adipose tissue and promotes fatty acid β-oxidation in hepatocytes. This compound has been shown to mitigate insulin resistance and inflammation triggered by palmitate or high-fat diets via an AMPK–PPARδ-dependent pathway in murine models. Additionally, 3-Aminoisobutyric acid sodium salt is a catabolic metabolite of thymine and valine in skeletal muscle. -
Anti-inflammatory Agent
Linalyl acetate is a phytochemical compound that primarily functions as an anti-inflammatory agent. It exhibits a range of biological activities including anti-anxiety and cardioprotective effects. This compound is useful in research focusing on inflammatory responses and offers potential applications in developing therapeutic agents for related conditions. Linalyl acetate's oral bioactivity further enhances its relevance in pharmacological studies. -
Anti-inflammatory Lipid Mediators
5,6-DiHETE is an anti-inflammatory lipid mediator that is synthesized from eicosapentaenoic acid (EPA). It plays a crucial role in mitigating vascular hyperpermeability during inflammatory responses, making it a valuable tool in the study of various inflammatory diseases. Researchers utilize 5,6-DiHETE to explore its therapeutic potential and elucidate the underlying mechanisms of inflammation. -
Anti-inflammatory Agent
Tiaramide is an anti-inflammatory agent that exerts its effects by inhibiting the release of prostaglandin E2 (PGE2). This compound also prevents the increase in intracellular free calcium levels induced by PGE2 and bradykinin, thereby mitigating bradykinin-induced contraction. Tiaramide is valuable for research applications focused on inflammatory pathways and calcium signaling in cellular models. -
Anti-inflammatory Agent
LQFM020 is an orally active pyrazole derivative that functions as an anti-inflammatory agent. It effectively inhibits calcium channels while activating potassium and nitric oxide/cGMP pathways, leading to reduced vasoconstriction. LQFM020 exhibits significant anti-inflammatory and analgesic properties, making it a valuable reagent for research focused on inflammation and pain mechanisms. -
Anti-inflammatory Agent
Trepibutone is an anti-inflammatory agent that enhances the secretion of bile and pancreatic juice while promoting smooth muscle flaccidity in the gastrointestinal tract. This compound serves as a valuable tool in the study of cholecystitis and various functional gastrointestinal disorders, providing insights into digestive health and inflammation-related conditions. -
Anti-inflammatory Agent
Resolvin E2, a proresolving lipid mediator, functions primarily as an anti-inflammatory agent. It plays a crucial role in resolving inflammation and promoting tissue repair through its influence on immune cell activities. This compound is utilized in research applications focused on inflammation resolution, chronic inflammatory diseases, and the modulation of immune responses. -
Anti-inflammatory Agent
LY269415 is a potent anti-inflammatory agent that acts as an inhibitor of iron-dependent lipid peroxidation and 5-lipoxygenase enzyme activity. This compound exhibits significant antioxidant properties, making it valuable for research focused on inflammatory pathways and related diseases. Its oral bioavailability allows for versatile applications in preclinical studies aimed at understanding inflammation-related mechanisms and potential therapeutic interventions. -
Anti-inflammatory Agent
Clidanac is a potent anti-inflammatory agent that acts by uncoupling oxidative phosphorylation. This mechanism contributes to its role in modulating inflammatory responses. Clidanac is primarily applied in research focused on conditions such as rheumatoid arthritis, making it a valuable tool for studying inflammation pathways and potential therapeutic interventions. -
Anti-Inflammatory Peptide
Collagen Type II Fragment is an anti-inflammatory peptide that effectively inhibits collagen-induced arthritis (CIA) in murine models. This fragment serves as a valuable tool for studying inflammation and immune responses, facilitating research aimed at understanding and developing therapies for autoimmune conditions.
