INCB39110 (Itacitinib)

Catalog No.: A14390

JAK1 Inhibitor

INCB39110 (Itacitinib)

INCB39110 (Itacitinib) Chemical Structure

CAS NO. 1334298-90-6

INCB39110 is a potent JAK1 tyrosine kinase inhibitor, which is currently in Phase II trials for the treatment of rheumatoid arthritis, myelofibrosis, rheumatoid arthritis and plaque psoriasis.

Availability: In stock

Package Price Qty
5 mg
$125.00
10 mg
$225.00
25 mg
$460.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Czech J, .et al. JAK2V617F but not CALR mutations confer increased molecular responses to interferon-α via JAK1/STAT1 activation, Leukemia, 2018, Nov 23 PMID: 30470838

Biological Activity

INCB39110 is a potent JAK1 tyrosine kinase inhibitor, which is currently in Phase II trials for the treatment of rheumatoid arthritis, myelofibrosis, rheumatoid arthritis and plaque psoriasis.
In vitro DMSO 88 mg/mL (158.98 mM)
Water Insoluble
Ethanol 88 mg/mL (158.98 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.07 mL 90.33 mL 180.67 mL
0.5 mM 3.61 mL 18.07 mL 36.13 mL
1 mM 1.81 mL 9.03 mL 18.07 mL
5 mM 0.36 mL 1.81 mL 3.61 mL

*The above data is based on the productmolecular weight 553.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A14390
Actions Inhibitor
CAS No. 1334298-90-6
Formula C26H23F4N9O
M. Wt 553.51
Purity >98%
Synonyms INCB 39110, INCB-39110, INCB039110, INCB-039110, INCB 039110
SMILES N#CCC1(N2N=CC(C3=C4C(NC=C4)=NC=N3)=C2)CN(C5CCN(C(C6=C(F)C(C(F)(F)F)=NC=C6)=O)CC5)C1
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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