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INCB39110 (Itacitinib)

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JAK1 Inhibitor

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Catalog No. A14390

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
INCB39110 5mg A14390-5

Regular Price: $350.00

Special Price: $315.00

INCB39110 10mg A14390-10

Regular Price: $500.00

Special Price: $450.00

INCB39110 25mg A14390-25

Regular Price: $1,000.00

Special Price: $900.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

INCB39110 is a potent JAK1 tyrosine kinase inhibitor, which is currently in Phase II trials for the treatment of rheumatoid arthritis, myelofibrosis, rheumatoid arthritis and plaque psoriasis.

INCB39110 (Itacitinib)

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Publications citing Adooq Products
INCB39110 (Itacitinib) Citations (1)
  • Czech J, .et al. JAK2V617F but not CALR mutations confer increased molecular responses to interferon-α via JAK1/STAT1 activation, Leukemia, 2018, Nov 23 PMID: 30470838

Chemical Information

Catalog Num A14390
Actions Inhibitor
M. Wt 553.51
Formula C26H23F4N9O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1334298-90-6
Synonyms INCB 39110, INCB-39110, INCB039110, INCB-039110, INCB 039110
SMILES N#CCC1(N2N=CC(C3=C4C(NC=C4)=NC=N3)=C2)CN(C5CCN(C(C6=C(F)C(C(F)(F)F)=NC=C6)=O)CC5)C1

Biological Activity

Description
INCB39110 is a potent JAK1 tyrosine kinase inhibitor, which is currently in Phase II trials for the treatment of rheumatoid arthritis, myelofibrosis, rheumatoid arthritis and plaque psoriasis.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.07 mL 90.33 mL 180.67mL
0.5 mM 3.61 mL 18.07 mL 36.13 mL
1 mM 1.81 mL 9.03 mL 18.07 mL
5 mM 0.36 mL 1.81 mL 3.61 mL

*The above data is based on the productmolecular weight 553.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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