Indole-4-carboxaldehyde functions as an NF-κB activator. This compound demonstrates the ability to attenuate the expression of inflammatory-related genes, including TNF-α and IFN-γ, in HepG2 cells, without exhibiting cytotoxic effects. Additionally, it reduces the formation of advanced glycation end products (AGEs) induced by methylglyoxal (MGO) and decreases the expression of the receptor for RAGE. Indole-4-carboxaldehyde is a valuable reagent for studies focused on hepatic steatosis and related inflammatory pathways.
Indole-4-carboxaldehyde functions as an NF-κB activator. This compound demonstrates the ability to attenuate the expression of inflammatory-related genes, including TNF-α and IFN-γ, in HepG2 cells, without exhibiting cytotoxic effects. Additionally, it reduces the formation of advanced glycation end products (AGEs) induced by methylglyoxal (MGO) and decreases the expression of the receptor for RAGE. Indole-4-carboxaldehyde is a valuable reagent for studies focused on hepatic steatosis and related inflammatory pathways.
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