InsB (9-23) is an MHC class II-restricted peptide derived from the insulin B-chain, encompassing amino acid residues 9-23. This peptide is a critical antigen for HLA-DQ8, facilitating T cell recognition and activation, leading to the release of IFN-γ and various cytokines. InsB (9-23) has been shown to activate CD4 T cells associated with the pathogenesis of type 1 diabetes and autoimmune diabetes. It serves as an essential tool for research investigating the immunological mechanisms underlying these diseases.
InsB (9-23) is an MHC class II-restricted peptide derived from the insulin B-chain, encompassing amino acid residues 9-23. This peptide is a critical antigen for HLA-DQ8, facilitating T cell recognition and activation, leading to the release of IFN-γ and various cytokines. InsB (9-23) has been shown to activate CD4 T cells associated with the pathogenesis of type 1 diabetes and autoimmune diabetes. It serves as an essential tool for research investigating the immunological mechanisms underlying these diseases.
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