IPI-145 (Duvelisib, INK1197)

Catalog No.: A12422

PI3K-δ/PI3K-γ inhibitor

IPI-145 (Duvelisib, INK1197) Chemical Structure

CAS NO. 1201438-56-3

IPI-145, also known as INK-1197, is an orally bioavailable, highly selective and potent small molecule inhibitor of the delta and gamma isoforms of phosphoinositide-3 kinase (PI3K) with potential immunomodulating and antineoplastic activities.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $65.00

Special Price $52.00

10 mg

Regular Price: $90.00

Special Price $72.00

25 mg

Regular Price: $130.00

Special Price $104.00

50 mg

Regular Price: $170.00

Special Price $136.00

10mM * 1mL in DMSO
$85.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

IPI-145, also known as INK-1197, is an orally bioavailable, highly selective and potent small molecule inhibitor of the delta and gamma isoforms of phosphoinositide-3 kinase (PI3K) with potential immunomodulating and antineoplastic activities.
Targets
Target Value
PI3Kδki: 23pM
PI3Kγki: 243pM
PI3Kδki: 23pM
PI3Kβki: 1564pM
PI3Kαki: 25900pM
PI3Kγki: 243pM
In vitro (25°C) DMSO 84 mg/mL (201.5 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.99 mL 119.94 mL 239.89 mL
0.5 mM 4.8 mL 23.99 mL 47.98 mL
1 mM 2.4 mL 11.99 mL 23.99 mL
5 mM 0.48 mL 2.4 mL 4.8 mL

*The above data is based on the productmolecular weight 416.86. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12422
Actions Inhibitor
M. Wt 416.86
Formula C22H17ClN6O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1201438-56-3
Synonyms IPI145; IPI 145; IPI-145. INK-1197; INK 1197; INK1197
SMILES C[[email protected]@H](C1=CC2=C(C(=CC=C2)Cl)C(=O)N1C3=CC=CC=C3)NC4=NC=NC5=C4NC=N5

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