Irigenin is an inhibitor of EDA-integrin interactions, specifically targeting α9β1 and α4β1 integrins by blocking their binding sites on the C-C loop of Extra Domain A (EDA). This compound exhibits significant anti-cancer properties, particularly in gastric cancer cells, where it enhances TRAIL-induced apoptosis by increasing the expression of pro-apoptotic molecules. Irigenin may be valuable in cancer research, particularly in studies focused on metastasis and apoptosis modulation.
Irigenin is an inhibitor of EDA-integrin interactions, specifically targeting α9β1 and α4β1 integrins by blocking their binding sites on the C-C loop of Extra Domain A (EDA). This compound exhibits significant anti-cancer properties, particularly in gastric cancer cells, where it enhances TRAIL-induced apoptosis by increasing the expression of pro-apoptotic molecules. Irigenin may be valuable in cancer research, particularly in studies focused on metastasis and apoptosis modulation.
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