Ironomycin is an apoptosis and ferroptosis inducer that targets critical pathways in cancer biology. This compound demonstrates selective inhibitory effects against mantle cell lymphoma (MCL) cells by inducing cell cycle arrest and promoting apoptosis and ferroptosis. Ironomycin causes double-strand DNA breaks and activates the unfolded protein response (UPR), particularly through the IRE1α signaling pathway. The combination of Ironomycin with Ibrutinib yields a synergistic effect, making it a valuable reagent for studying MCL and exploring therapeutic strategies in cancer research.
Ironomycin is an apoptosis and ferroptosis inducer that targets critical pathways in cancer biology. This compound demonstrates selective inhibitory effects against mantle cell lymphoma (MCL) cells by inducing cell cycle arrest and promoting apoptosis and ferroptosis. Ironomycin causes double-strand DNA breaks and activates the unfolded protein response (UPR), particularly through the IRE1α signaling pathway. The combination of Ironomycin with Ibrutinib yields a synergistic effect, making it a valuable reagent for studying MCL and exploring therapeutic strategies in cancer research.
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