Catalog No.
Product Name
Application
Product Information
Citations
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ferroptosis inhibitor
Ferrostatin-1 (Fer-1) is a potent and selective inhibitor of ferroptosis with EC50 of 60 nM.- Cheng Chen, .et al. , Neurochem Res, 2025, Mar 18;50(2):122 PMID: 40100474
- Yin-Yin Wang, .et al. , Bioorg Chem, 2025, May:158:108342 PMID: 40058224
- Filiz Bakar-Ates, .et al. , Naunyn Schmiedebergs Arch Pharmacol, 2024, Oct 11 PMID: 39392483
- Rushikesh Deshpande, .et al. , Int J Mol Sci, 2024, Jan 18;25(2):1157 PMID: 38256231
- Huan Yang, .et al. , Theriogenology, 2024, Feb:215:281-289 PMID: 38103405
- Filiz Bakar-Ates, .et al. , Toxicol In Vitro, 2024, Feb:94:105732 PMID: 37956772
- Binjie Yan, .et al. , Cell Death Discov, 2023, 9: 456 PMID: 38097554
- Panpan Tai, .et al. , J Transl Med, 2023, Nov 17;21(1):823 PMID: 37978379
- Chengzhu Song, .et al. , Food Funct, 2023, Jan 23;14(2):1087-1098 PMID: 36594456
- Erva Ozkan, .et al. , Life Sci, 2023, Jan 1;312:121222 PMID: 36442526
- Xueyan Zhang, .et al. , DNA Cell Biol, 2022, Aug;41(8):705-715 PMID: 35687364
- A Xavier, .et al. , Cell Rep, 2020, May 19;31(7):107667 PMID: 32433976
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Ferroptosis inhibitor
RSL3 is a ferroptosis activator in a VDAC-independent manner,exhibiting selectivity for tumor cells bearing oncogenic RAS.- Duo Shi, .et al. , Antioxid Redox Signal, 2025, Sep 30 PMID: 41027674
- Cheng Chen, .et al. , Neurochem Res, 2025, Mar 18;50(2):122 PMID: 40100474
- Xiaona Cao, .et al. , J Nanobiotechnology, 2025, Feb 24;23(1):136 PMID: 39994619
- Naoya Yamada, .et al. , Nat Commun, 2024, 15:2195 PMID: 38472233
- Ning Li, .et al. , J Ovarian Res, 2024, Feb 23;17(1):49 PMID: 38396022
- Yuki Kojima, .et al. , Journal of Gastroenterology, 2023, Nov 10
- Qingyu Zhang, .et al. , Cell Death Discov, 2023, Mar 8;9(1):83 PMID: 36882396
- Sampilvanjil A, .et al. , Am J Physiol Heart Circ Physiol, 2020, Mar 1;318(3):H508-H518 PMID: 31975626
- Fujiki K, .et al. , Cell Death Differ, 2019, Feb 25 PMID: 30804470
- Samantha W. Alvarez, .et al. , Nature, 2017, Nov 30; 551(7682): 639-643 PMID: 29168506
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VDAC inhibitor
Erastin is a cell-permeable piperazinyl-quinazolinone compound that exhibits oncogene-selective lethality in cells with H-Ras mutations.- Mao Yang, .et al. , Biochem Biophys Res Commun, 2025, Sep 5:784:152599 PMID: 40972362
- Xuejie Huan, .et al. , Neurosci Bull, 2024, Dec 12 PMID: 39666195
- Filiz Bakar-Ates, .et al. , Naunyn Schmiedebergs Arch Pharmacol, 2024, Oct 11 PMID: 39392483
- Filiz Bakar-Ates, .et al. , Toxicol In Vitro, 2024, Feb:94:105732 PMID: 37956772
- Sureya Nijiati, .et al. , Mol Pharm, 2023, Oct 2;20(10):5185-5194 PMID: 37711135
- Erva Ozkan, .et al. , Life Sci, 2023, Jan 1;312:121222 PMID: 36442526
- Yuki Shibata, .et al. , Biochem Biophys Rep, 2021, Feb 24;26 PMID: 33681481
- Shibata Y, .et al. , PLoS One, 2019, Dec 4;14(12):e0225931 PMID: 31800616
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GPX4 inhibitor
ML-210??the most potent compound in the nitroisoxazole series?? is a selective covalent inhibitor of glutathione peroxidase 4 (GPX4) by binding the selenocysteine residue.- Ning Li, .et al. , J Ovarian Res, 2024, Feb 23;17(1):49 PMID: 38396022
- Sulfasalazine is a drug for the treatment of rheumatoid arthritis and ulcerative colitis. Sulfasalazine is reported to suppress NF-κB activity.
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Kinases PROTAC
DB1113 is a bifunctional compound designed for targeted protein degradation of various kinases. It effectively induces degradation of ABL1, ABL2, BLK, CDK4, CDK11B, EPHA3, MAPK7, RIPK1, and others, facilitating the investigation of kinase-related signaling pathways. DB1113 is suitable for research focusing on diseases or disorders associated with dysregulated kinase activity, providing a valuable tool for exploring therapeutic interventions in cancer and other conditions. -
Apoptosis/Ferroptosis Inducer
Ironomycin is an apoptosis and ferroptosis inducer that targets critical pathways in cancer biology. This compound demonstrates selective inhibitory effects against mantle cell lymphoma (MCL) cells by inducing cell cycle arrest and promoting apoptosis and ferroptosis. Ironomycin causes double-strand DNA breaks and activates the unfolded protein response (UPR), particularly through the IRE1α signaling pathway. The combination of Ironomycin with Ibrutinib yields a synergistic effect, making it a valuable reagent for studying MCL and exploring therapeutic strategies in cancer research. -
ferroptosis inducer
Solasonine is a naturally occurring steroidal glycoalkaloid isolated from *Solanum melongena* (eggplant), known for its anti-infective, anticancer, and neurogenesis-promoting properties. It acts as a ferroptosis inducer by disrupting the glutathione redox system through inhibition of glutathione peroxidase 4 (GPX4). By promoting ferroptotic cell death in hepatocellular carcinoma (HCC) cells, Solasonine serves as a valuable compound for investigating ferroptosis mechanisms and developing novel anticancer strategies. -
Fluorescent Dye
BODIPY 581/591 C11 is a boron-dipyrromethene (BODIPY) derivative with excellent photostability and minimal fluorescence artifacts. It is widely used to study lipid peroxidation and antioxidant activity in living cells, and to detect ferroptosis through its reaction with hydroxyl radicals. The dye exhibits a fluorescence shift upon oxidation: the reduced form emits at 591 nm (Ex: 581 nm), while the oxidized form emits at 510 nm (Ex: 500 nm). -
Ferroptosis inhibitor
SRS11-92 is a potent ferroptosis inhibitor and structural analogue of Ferrostatin-1 (Fer-1). It effectively blocks Erastin-induced ferroptotic cell death in HT-1080 human fibrosarcoma cells, with an EC₅₀ of 6 nM. SRS11-92 serves as a valuable tool for studying ferroptosis and its therapeutic modulation in oxidative stress-related diseases and cancer. -
PROTAC NCOA4 degrader
PROTAC NCOA4 Degrader-1 (Compound V3) is a highly potent PROTAC targeting NCOA4, with a DC₅₀ of 3 nM in HeLa cells. It functions as a ferroptosis inhibitor by reducing NCOA4 levels and lowering intracellular ferrous iron (Fe²⁺) concentrations. PROTAC NCOA4 Degrader-1 has demonstrated protective effects in a CCl₄-induced acute liver injury model, making it a valuable tool for studying ferroptosis and liver disease therapeutics. -
Ferroptosis Activator
Ammonium iron(III) citrate serves as a ferroptosis activator through the induction of intracellular iron overload. By increasing cellular iron levels, it promotes oxidative stress and contributes to ferroptotic cell death. This compound is valuable for research involving cellular iron metabolism, oxidative stress studies, and investigations into ferroptosis-related pathways. Additionally, it may enhance protein production, making it relevant for applications in biochemical assays and cellular biology research. -
Ferroptosis Inhibitor
1(R)-(Trifluoromethyl)oleyl alcohol is a trifluoromethyl alcohol derivative of oleic acid that functions as a ferroptosis inhibitor. This compound effectively attenuates ferroptosis induced by Erastin and mitigates lipid peroxidation in human myoblasts with frataxin (FXN) siRNA knockdown. At a concentration of 40 μM, it enhances cell survival to 95% in models of Friedreich ataxia where cell death is largely driven by iron accumulation and glutathione depletion. This makes 1(R)-(Trifluoromethyl)oleyl alcohol a valuable reagent for studying ferroptosis and its related pathways in neurodegenerative diseases. -
Ferroptosis Inhibitor
Ferroptosis-IN-3 is a potent ferroptosis inhibitor targeting the ferroptotic cell death pathway. It effectively inhibits RSL3-induced ferroptosis in HT-1080 cells with an EC50 of 8.6 nM. Additionally, Ferroptosis-IN-3 demonstrates strong free radical scavenging properties, with EC50 values of 3.94 μM for DPPH and 6.3 μM for ABTS, and reduces lipid peroxidation. This compound is ideal for research focused on oxidative stress and cell death mechanisms. -
Glyceraldehyde Derivative
TOFA-Plasmalogen is a glyceraldehyde derivative that induces ferroptosis through the promotion of lipid peroxidation on cellular membranes. This compound exhibits cytotoxic effects with an IC50 of 32.87 μM. TOFA-Plasmalogen is valuable for research applications focused on understanding the mechanisms of cell death and oxidative stress-related disorders. -
Ferroptosis Inhibitor
Ferroptosis Inducer-6 is a potent inducer of ferroptosis, primarily functioning through the generation of reactive oxygen species (ROS) and the induction of oxidative stress and mitochondrial damage. This compound exhibits anti-tumor activity and serves as a valuable tool for research in type I and II photodynamic therapy. Its ability to trigger ferroptotic cell death makes it significant for studies focused on cancer treatment and exploring the mechanisms of cell death pathways. -
Ferroptosis Inducer
Lepadin E is a potent ferroptosis inducer that activates cell death through the classical p53-SLC7A11-GPX4 pathway. By promoting p53 expression and downregulating SLC7A11 and GPX4, Lepadin E enhances reactive oxygen species (ROS) and lipid peroxide production while increasing ACSL4 expression. This mechanism underlies its significant antitumor efficacy, making Lepadin E a valuable tool for studying ferroptosis in cancer research. -
Ferroptosis Inhibitor
Ferroptosis-IN-11 is a potent ferroptosis inhibitor targeting the pathways involved in iron-mediated cell death. It effectively inhibits Erastin-induced ferroptosis in HT-1080 human fibroblasts, demonstrating an EC50 of 36 nM. This compound is valuable for research into cardiovascular diseases and neurodegenerative disorders, providing insights into the mechanisms of ferroptosis and potential therapeutic strategies. -
Ferroptosis/MAO-B Inhibitor
MAO-B-IN-45 is a selective inhibitor of MAO-B with an IC50 of 87.47 nM, demonstrating over 229-fold selectivity for MAO-B compared to MAO-A. This compound exhibits significant antiferroptosis activity by modulating the iron metabolic pathway and the glutathione peroxidase 4 (GPX4) axis in vitro. Research indicates that MAO-B-IN-45 enhances cognitive and behavioral functions in 3×Tg (APP/Tau/Ps1) Alzheimer's disease mouse models, while also reducing levels of ferritin heavy chain 1 (FTH1), amyloid precursor protein (APP), and phosphorylated Tau (p-Tau) in the brain. -
Ferroptosis/Apoptosis Inducer
Lepadin H is a potent ferroptosis and apoptosis inducer, demonstrating significant in vitro cytotoxicity and in vivo antitumor efficacy against cancer cells. This compound functions by decreasing the levels of GPX4 and SLC7A11, while enhancing p53 and ACSL4 expression. Lepadin H promotes the generation of lipid hydroperoxides and increases reactive oxygen species (ROS), leading to a reduction in cellular glutathione (GSH) levels and lipid peroxidation. Additionally, it causes G2/M phase cell cycle arrest and inhibits the clonogenic growth and migration of melanoma cells, making it a valuable tool for cancer research. -
Ferroptosis Inducer
AX-53802 is a potent ferroptosis inducer that targets glutathione peroxidase 4 (GPX4) with an IC50 value of 0.34 µM. This compound covalently binds to GPX4, facilitating membrane translocation and subsequent triggering of ferroptotic cell death. In combination with FAK/Src inhibitors, AX-53802 enhances the induction of cell death, making it a valuable tool for cancer research and studies involving ferroptosis mechanisms. -
Ferroptosis Inducer
Ferroptosis inducer-7 selectively induces ferroptosis via the inositol 1,4,5-trisphosphate receptor (IP3R) and calcium release-activated calcium channel protein (ORAI). This compound demonstrates significant biological activity in alleviating symptoms of anemia, suppressing activation of bone marrow cytotoxic T lymphocytes (CTLs), and enhancing hematopoietic function in cases of immune-mediated bone marrow failure. Ferroptosis inducer-7 is valuable for research applications focused on aplastic anemia and related hematological conditions. -
Ferroptosis Inhibitor
Ferrostatin-1 diyne is a potent ferroptosis inhibitor that selectively targets the ferroptotic pathway. This compound is known to accumulate in lysosomes, mitochondria, and the endoplasmic reticulum of cells. Notably, its inhibition of ferroptosis occurs independently of lysosomal and mitochondrial activity, making it a valuable tool for studying ferroptosis-related mechanisms and evaluating therapeutic strategies in various research applications. -
Ferroptosis Inducer
Anticancer agent 147 is a ferroptosis inducer that promotes intracellular accumulation of Fe2+, reactive oxygen species (ROS), and malondialdehyde (MDA). This compound enhances endoplasmic reticulum (ER) stress and upregulates the expression of activating transcription factor ATF3. Anticancer agent 147 exhibits significant anti-liver cancer effects in both in vitro and in vivo models, making it a valuable tool for research in cancer therapy and cell death mechanisms. -
Ferroptosis Inhibitor
RC574 is a novel ferroptosis inhibitor that protects mouse hippocampal cells and primary cortical neurons from glutamate-induced oxidative cell death. It enhances levels and activity of glutathione peroxidase 1 (GPx1), vital for cellular antioxidant defense. This compound is valuable for research into neuroprotection and the mechanisms underlying ferroptosis in neurodegenerative diseases. -
Apoptosis/Ferroptosis Inducer
GIC-20 is a dual inducer of apoptosis and ferroptosis, acting on key cellular pathways involved in programmed cell death. This compound demonstrates significant antitumor efficacy, particularly against fibrosarcoma. GIC-20 is valuable for research applications aimed at exploring mechanisms of cell death and potential therapeutic strategies in cancer biology. -
Ferroptosis Inducer
Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III) acts as a ferroptosis inducer by generating lipid-based reactive oxygen species (ROS). This compound is instrumental for research exploring the mechanisms of ferroptosis, a form of regulated cell death characterized by iron-dependent lipid peroxidation. It is valuable for studies investigating cancer biology, neurodegenerative diseases, and other conditions where ferroptosis plays a critical role. -
Ferroptosis Inhibitor
Ferroptosis-IN-4 is a potent ferroptosis inhibitor, exhibiting an EC50 value of 20 μM. This compound demonstrates minimal cytotoxicity, highlighting its safety for biological applications. Ferroptosis-IN-4 provides a protective effect in models of glycerol-induced renal acute kidney injury (RM-AKI), effectively alleviating kidney dysfunction. Its ability to modulate ferroptosis makes it a valuable tool for research in cellular stress responses and kidney-related disorders. -
Ferroptosis Inducers
Ferroptocide is a potent inducer of ferroptosis, a form of regulated cell death characterized by iron-dependent lipid peroxidation. It effectively induces oxidative stress, resulting in G2/M cell cycle arrest and apoptosis in LNCaP cells, and significantly reduces cell viability in both LNCaP and TRAMP-C1 prostate cancer cell lines. Ferroptocide serves as a valuable tool for investigating mitochondrial autophagy and evaluating its potential to trigger immunogenic cell death (ICD) in prostate cancer research. -
Ferroptosis Inducer
Chaetoglobosin E is a potent ferroptosis inducer that targets and downregulates GPX4 expression in human tumor cell lines. It exhibits significant cytotoxic effects, with IC50 values of 9.14 μM against MDA-MB231 cells and 7.47 μM against A549 cells. The compound elevates intracellular Fe2+ levels and increases the lipid peroxidation marker malondialdehyde (MDA), resulting in mitochondrial alterations and the induction of ferroptosis. Chaetoglobosin E serves as a valuable tool for cancer research and the study of ferroptosis mechanisms. -
Ferroptosis Inducer
Fluorescein-diisobutyrate-6-amide is a potent ferroptosis inducer targeting the cell death pathway associated with iron metabolism. This compound primarily promotes oxidative stress, leading to lipid peroxidation and subsequent cell apoptosis. Fluorescein-diisobutyrate-6-amide is valuable for research applications in cancer biology, particularly in understanding ferroptosis mechanisms and exploring novel therapeutic strategies against various malignancies. -
Ferroptosis Inducer
Talaroconvolutin A is a potent ferroptosis inducer that primarily acts by elevating reactive oxygen species (ROS) levels while bypassing the GPX4 pathway. This compound downregulates the expression of solute carrier family 7 member 11 (SLC7A11) and enhances arachidonic acid lipoxygenase 3 (ALOXE3) levels. Talaroconvolutin A demonstrates significant cytotoxicity in colorectal cancer cells (HCT116) and bladder cancer cells (SW480), with IC50 values of 1.22 μM and 1.4 μM, respectively. This reagent is valuable for researching ferroptosis mechanisms and therapeutic strategies in colorectal and bladder cancers. -
Ferroptosis Inhibitor
5-Hydroxy-6,7-dimethoxyflavone is a potent inhibitor of ferroptosis, acting primarily to mitigate H1N1 virus-induced cell death. This compound enhances the expression of SLC7A11 and GPX4, thereby providing protective effects against ferroptosis. Additionally, it reduces inflammatory responses and apoptosis by inhibiting the activation of NF-κB and p38 MAPK signaling pathways. 5-Hydroxy-6,7-dimethoxyflavone is valuable for research related to H1N1 influenza virus infection and ferroptosis regulation. -
Ferroptosis inhibitor
3-Hydroxyindole is a hydroxyindole derivative known for its potent antioxidant activity. It exhibits inhibitory effects against DPPH and crocin, making it a valuable tool in studies of oxidative stress. Additionally, 3-hydroxyindole is recognized for its role as a ferroptosis inhibitor, facilitating research into this regulated form of cell death and its implications in various diseases. -
Ferroptosis Inducer
(1R,3R)-Ferroptosis inducer-1 is a selective ferroptosis inducer that demonstrates significant antitumor activity. This compound promotes ferroptotic cell death, a form of regulated necrosis characterized by lipid peroxidation, making it valuable for research in cancer biology. It has potential applications in the study of therapeutic strategies targeting ferroptosis in various cancer types. -
Ferroptosis Inducer
NA-Ir is a potent ferroptosis inducer that targets mitochondrial DNA (mtDNA) and activates the cGAS-STING signaling pathway, promoting ferritinophagy. It generates reactive oxygen species (ROS) through photodynamic therapy (PDT) while depleting glutathione (GSH) and downregulating glutathione peroxidase 4 (GPX4), leading to lipid peroxidation and the initiation of ferroptosis. NA-Ir demonstrates increased anticancer efficacy when exposed to light, selectively impairing cancer cells characterized by elevated levels of hydrogen sulfide (H2S). -
Ferroptosis Makers
PRDX3(103-112), human is a critical marker for ferroptosis, a form of regulated cell death influenced by oxidative stress. This peptide is generated from PRDX3, which undergoes hyperoxidation in response to mitochondrial lipid peroxides. Following hyperoxidation, PRDX3 plays a role in the inhibition of cystine uptake, contributing to the regulation of glutathione and cellular redox balance. Applications include studying the mechanisms of ferroptosis in various disease models and evaluating therapeutic interventions targeting oxidative stress. -
Ferroptosis Inducer
Ferroptosis inducer-8 is a potent ferroptosis inducer that selectively targets other cell death pathways. It functions by modulating the expression of ACSL4, GPX4, and FTH1, thereby disrupting iron homeostasis and impairing the GSH/GPX4 antioxidant defense system. This mechanism facilitates lipid peroxidation and promotes reactive oxygen species (ROS) production. Ferroptosis inducer-8 has demonstrated efficacy in inhibiting tumor growth, making it a valuable tool for research in triple-negative breast cancer (TNBC) and other malignancies. -
Ferroptosis Inhibitor
Ferroptosis-IN-5 is a potent ferroptosis inhibitor that functions by chelating iron and scavenging reactive oxygen species (ROS). This compound effectively mitigates ferroptotic cell death, making it valuable for research in cancer biology and neurodegeneration. Applications include investigating the mechanisms of ferroptosis and evaluating potential therapeutic interventions in various diseases associated with oxidative stress. -
Ferroptosis Inducer
BG11 is a potent ferroptosis inducer that promotes the accumulation of Fe2+ ions and intracellular lipid peroxides, leading to ferroptotic cell death. It modulates the expression of apoptotic regulators such as Bax and Bcl-2, facilitating apoptosis in MDA-MB-231 breast cancer cells. Furthermore, BG11 causes G0/G1 and S phase cell cycle arrest, significantly inhibiting the proliferation, migration, and invasion of triple-negative breast cancer (TNBC) cells, with IC50 values of 0.49 μM for MDA-MB-231 and 0.52 μM for BT549. In preclinical mouse models, BG11 demonstrates notable antitumor efficacy. -
Ferroptosis Inhibitor
Ferfluor-1 is a potent ferroptosis inhibitor, demonstrating EC50 values of 57 nM in HT108 cells, 75 nM in OS-RC-2 cells, and 2.3 nM in SH-SY5Y neuroblastoma cells. This ratiometric photoluminescent probe is capable of crossing the blood-brain barrier, making it an effective tool for monitoring ferroptotic changes in cellular environments. Ferfluor-1 shows promise in research applications related to neurodegenerative diseases, such as stroke and Parkinson's disease, by mitigating the effects of ferroptosis in in vivo models. -
Ferroptosis Inducer
Anti-TNBC agent-13 is a ferroptosis inducer designed to target and inhibit GPX4 activity. By promoting the accumulation of lipid peroxides, it triggers cell death specifically in triple-negative breast cancer (TNBC) cells. This compound serves as a valuable research tool for studying ferroptosis and its therapeutic potential in TNBC. -
Ferroptosis Inducer
Ferroptosis inducer-13 is a 5′-prenylated chalcone derivative that targets and induces ferroptosis in human non-small cell lung cancer (NSCLC) cells by modulating the Nrf2/xCT/GPX4 pathway. This compound demonstrates significant anti-proliferative effects in vitro and effectively inhibits tumor growth in NSCLC mouse models. Ferroptosis inducer-13 serves as a valuable tool for research focused on the mechanisms and treatment of NSCLC. -
Ferroptosis Inducer
Cetzole is a potent ferroptosis inducer that promotes cell death through the accumulation of reactive oxygen species (ROS). With CC50 values ranging from 2.56 μM in NCI-H522 cells to 14.9 μM in NARF2 cells, Cetzole demonstrates significant cytotoxicity across various cancer cell lines. This compound is valuable for research focused on cancer biology and the mechanisms of ferroptosis. -
Ferroptosis Inhibitor
Ferroptosis-IN-15 is a potent ferroptosis inhibitor, exhibiting EC50 values of 0.76 μM in A375 cells and 0.67 μM in 786-O cells. This compound functions as a potential iron chelator and radical trapping antioxidant, making it a valuable tool for studying the mechanisms of ferroptosis. Its ability to modulate ferroptotic cell death contributes to research in cancer biology and neurodegenerative disorders. -
Ferroptosis Inducer
Ferroptosis Inducer-5 (compound 20a) is a potent inducer of ferroptosis, a form of regulated cell death characterized by lipid peroxidation and iron dependency. It exhibits significant biological activity in promoting ferroptotic cell death in various cancer cell lines. This reagent is valuable for research applications exploring the mechanisms of ferroptosis and its therapeutic implications in cancer treatment. -
Ferroptosis Inhibitor
Ferroptosis-IN-18 is a potent ferroptosis inhibitor that exhibits significant anti-ferroptotic and antioxidant properties. This compound is particularly relevant in research focused on intracerebral hemorrhage (ICH), providing valuable insights into the mechanisms of ferroptosis and potential therapeutic approaches. Its ability to modulate ferroptosis-related pathways makes it a valuable tool in the understanding of oxidative stress-related conditions. -
Ferroptosis inhibitor
Myosin-IN-3 is a pyrimidine ketone derivative that functions as a ferroptosis inhibitor. Demonstrating potent anti-ferroptotic activity with an IC50 of 3.11 μM, it also effectively inhibits myosin activity (IC50 = 3.09 μM) and exhibits antioxidant properties, as evidenced by DPPH (EC50 = 23.17 μM) and MDA (EC50 = 55.34 μM) assays. Myosin-IN-3 is applicable in research related to cardiovascular diseases, including hypertrophic cardiomyopathy. -
Ferroptosis Inducer
Ferroptosis inducer-4 is a potent ferroptosis inducer that introduces terminal double bonds at the sn-2 position of phospholipids. This compound exhibits significant cytotoxicity in HT-1080 cells, with an IC50 of 18 μM, through the generation of lipid peroxides leading to oxidative damage of the cell membrane. Ferroptosis inducer-4 is valuable for research involving the regulation and mechanisms of ferroptosis in various biological contexts. -
Apoptosis/Ferroptosis Inducer
Anticancer agent 199 is an apoptosis and ferroptosis inducer targeting multiple signaling pathways in triple negative breast cancer (TNBC) cells. It promotes cell death through the mitochondrial pathway by inhibiting EGFR, AKT, and MAPK signaling, while simultaneously down-regulating LCN2 to induce ferroptosis. This compound effectively reduces TNBC cell viability and migration, and induces S phase cell cycle arrest, making it a valuable tool for research on cancer therapeutics. Anticancer agent 199 is a derivative of the cyclin-dependent kinase inhibitor Rocovitine.
