Catalog No.
Product Name
Application
Product Information
Citations
- Sulfasalazine is a drug for the treatment of rheumatoid arthritis and ulcerative colitis. Sulfasalazine is reported to suppress NF-κB activity.
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ferroptosis inhibitor
Ferrostatin-1 (Fer-1) is a potent and selective inhibitor of ferroptosis with EC50 of 60 nM.- Cheng Chen, .et al. , Neurochem Res, 2025, Mar 18;50(2):122 PMID: 40100474
- Yin-Yin Wang, .et al. , Bioorg Chem, 2025, May:158:108342 PMID: 40058224
- Filiz Bakar-Ates, .et al. , Naunyn Schmiedebergs Arch Pharmacol, 2024, Oct 11 PMID: 39392483
- Rushikesh Deshpande, .et al. , Int J Mol Sci, 2024, Jan 18;25(2):1157 PMID: 38256231
- Huan Yang, .et al. , Theriogenology, 2024, Feb:215:281-289 PMID: 38103405
- Filiz Bakar-Ates, .et al. , Toxicol In Vitro, 2024, Feb:94:105732 PMID: 37956772
- Binjie Yan, .et al. , Cell Death Discov, 2023, 9: 456 PMID: 38097554
- Panpan Tai, .et al. , J Transl Med, 2023, Nov 17;21(1):823 PMID: 37978379
- Chengzhu Song, .et al. , Food Funct, 2023, Jan 23;14(2):1087-1098 PMID: 36594456
- Erva Ozkan, .et al. , Life Sci, 2023, Jan 1;312:121222 PMID: 36442526
- Xueyan Zhang, .et al. , DNA Cell Biol, 2022, Aug;41(8):705-715 PMID: 35687364
- A Xavier, .et al. , Cell Rep, 2020, May 19;31(7):107667 PMID: 32433976
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15-LO inhibitor
PD146176 (NSC168807) is a 15-Lipoxygenase (15-LO) inhibitor, which inhibits rabbit reticulocyte 15-LO with a Ki of 197 nM. PD146176 (NSC168807) has a dramatic effect in reducing atherogenesis. -
VDAC inhibitor
Erastin is a cell-permeable piperazinyl-quinazolinone compound that exhibits oncogene-selective lethality in cells with H-Ras mutations.- Mao Yang, .et al. , Biochem Biophys Res Commun, 2025, Sep 5:784:152599 PMID: 40972362
- Xuejie Huan, .et al. , Neurosci Bull, 2024, Dec 12 PMID: 39666195
- Filiz Bakar-Ates, .et al. , Naunyn Schmiedebergs Arch Pharmacol, 2024, Oct 11 PMID: 39392483
- Filiz Bakar-Ates, .et al. , Toxicol In Vitro, 2024, Feb:94:105732 PMID: 37956772
- Sureya Nijiati, .et al. , Mol Pharm, 2023, Oct 2;20(10):5185-5194 PMID: 37711135
- Erva Ozkan, .et al. , Life Sci, 2023, Jan 1;312:121222 PMID: 36442526
- Yuki Shibata, .et al. , Biochem Biophys Rep, 2021, Feb 24;26 PMID: 33681481
- Shibata Y, .et al. , PLoS One, 2019, Dec 4;14(12):e0225931 PMID: 31800616
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Ferroptosis inhibitor
RSL3 is a ferroptosis activator in a VDAC-independent manner,exhibiting selectivity for tumor cells bearing oncogenic RAS.- Cheng Chen, .et al. , Neurochem Res, 2025, Mar 18;50(2):122 PMID: 40100474
- Xiaona Cao, .et al. , J Nanobiotechnology, 2025, Feb 24;23(1):136 PMID: 39994619
- Naoya Yamada, .et al. , Nat Commun, 2024, 15:2195
- Ning Li, .et al. , J Ovarian Res, 2024, Feb 23;17(1):49 PMID: 38396022
- Yuki Kojima, .et al. , Journal of Gastroenterology, 2023, Nov 10
- Qingyu Zhang, .et al. , Cell Death Discov, 2023, Mar 8;9(1):83 PMID: 36882396
- Sampilvanjil A, .et al. , Am J Physiol Heart Circ Physiol, 2020, Mar 1;318(3):H508-H518 PMID: 31975626
- Fujiki K, .et al. , Cell Death Differ, 2019, Feb 25 PMID: 30804470
- Samantha W. Alvarez, .et al. , Nature, 2017, Nov 30; 551(7682): 639-643 PMID: 29168506
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iron-chelating drug
Deferiprone is the only orally active iron-chelating drug to be used therapeutically in conditions of transfusional iron overload. -
excitatory transmitter/agonist
L-Glutamic acid monosodium salt acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). (S)-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals. -
ferroptosis inhibitor
Liproxstatin-1 is a potent ferroptosis inhibitor and inhibits ferroptotic cell death (IC50=22 nM). - Butylated hydroxytoluene is di-tert-butyl PHENOL with antioxidant properties.
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non-essential amino acid
DL-Glutamine (Glutamin, 2-amino-4-carbamoylbutanoic acid) is a non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes. -
chelating agent
Ethylenediaminetetraacetic acid trisodium salt (EDTA trisodium salt) is used to bind metal ions in the practice of chelation therapy, for treating mercury and lead poisoning, used in a similar manner to remove excess iron from the body, for treating the complication of repeated blood transfusions, as would be applied to treat thalassaemia. -
thromboxane A2 (TXA2) receptor (TP receptor) antagonist
Seratrodast is a thromboxane A2 (TXA2) receptor (TP receptor) antagonist used primarily in the treatment of asthma. -
Bcl-2 Family activator
(E)-Ferulic acid is a isomer of Ferulic acid which is an aromatic compound, abundant in plant cell walls. (E)-Ferulic acid shows a potent ability to remove reactive oxygen species (ROS) and inhibits lipid peroxidation. (E)-Ferulic acid exerts both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299. -
GPX4 inhibitor
ML-210??the most potent compound in the nitroisoxazole series?? is a selective covalent inhibitor of glutathione peroxidase 4 (GPX4) by binding the selenocysteine residue.- Ning Li, .et al. , J Ovarian Res, 2024, Feb 23;17(1):49 PMID: 38396022
- Artefenomel (OZ439) is a synthetic antimalarial agent with the artemisinin pharmacophore. Artefenomel (OZ439) is a long-acting artemisinin-related agent.
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Ferroptosis inhibitor
UAMC-3203 hydrochloride is a potent and selective Ferroptosis inhibitor with an IC50 of 12 nM. -
g-glutamylcysteine synthetase inhibitor
L-Buthionine-(S,R)-sulfoximine is a cell-permeable, potent, fast acting and irreversible inhibitor of g-glutamylcysteine synthetase and depletes cellular glutathione levels. -
ferroptosis inducer
Solasonine is a naturally occurring steroidal glycoalkaloid isolated from *Solanum melongena* (eggplant), known for its anti-infective, anticancer, and neurogenesis-promoting properties. It acts as a ferroptosis inducer by disrupting the glutathione redox system through inhibition of glutathione peroxidase 4 (GPX4). By promoting ferroptotic cell death in hepatocellular carcinoma (HCC) cells, Solasonine serves as a valuable compound for investigating ferroptosis mechanisms and developing novel anticancer strategies. -
Fluorescent Dye
BODIPY 581/591 C11 is a boron-dipyrromethene (BODIPY) derivative with excellent photostability and minimal fluorescence artifacts. It is widely used to study lipid peroxidation and antioxidant activity in living cells, and to detect ferroptosis through its reaction with hydroxyl radicals. The dye exhibits a fluorescence shift upon oxidation: the reduced form emits at 591 nm (Ex: 581 nm), while the oxidized form emits at 510 nm (Ex: 500 nm). -
Ferroptosis inhibitor
SRS11-92 is a potent ferroptosis inhibitor and structural analogue of Ferrostatin-1 (Fer-1). It effectively blocks Erastin-induced ferroptotic cell death in HT-1080 human fibrosarcoma cells, with an EC₅₀ of 6 nM. SRS11-92 serves as a valuable tool for studying ferroptosis and its therapeutic modulation in oxidative stress-related diseases and cancer. -
PROTAC NCOA4 degrader
PROTAC NCOA4 Degrader-1 (Compound V3) is a highly potent PROTAC targeting NCOA4, with a DC₅₀ of 3 nM in HeLa cells. It functions as a ferroptosis inhibitor by reducing NCOA4 levels and lowering intracellular ferrous iron (Fe²⁺) concentrations. PROTAC NCOA4 Degrader-1 has demonstrated protective effects in a CCl₄-induced acute liver injury model, making it a valuable tool for studying ferroptosis and liver disease therapeutics. -
Kinases PROTAC
DB1113 is a bifunctional compound designed for targeted protein degradation of various kinases. It effectively induces degradation of ABL1, ABL2, BLK, CDK4, CDK11B, EPHA3, MAPK7, RIPK1, and others, facilitating the investigation of kinase-related signaling pathways. DB1113 is suitable for research focusing on diseases or disorders associated with dysregulated kinase activity, providing a valuable tool for exploring therapeutic interventions in cancer and other conditions. -
Apoptosis/Ferroptosis Inducer
Ironomycin is an apoptosis and ferroptosis inducer that targets critical pathways in cancer biology. This compound demonstrates selective inhibitory effects against mantle cell lymphoma (MCL) cells by inducing cell cycle arrest and promoting apoptosis and ferroptosis. Ironomycin causes double-strand DNA breaks and activates the unfolded protein response (UPR), particularly through the IRE1α signaling pathway. The combination of Ironomycin with Ibrutinib yields a synergistic effect, making it a valuable reagent for studying MCL and exploring therapeutic strategies in cancer research. -
Ferroptosis Activator
Ammonium iron(III) citrate serves as a ferroptosis activator through the induction of intracellular iron overload. By increasing cellular iron levels, it promotes oxidative stress and contributes to ferroptotic cell death. This compound is valuable for research involving cellular iron metabolism, oxidative stress studies, and investigations into ferroptosis-related pathways. Additionally, it may enhance protein production, making it relevant for applications in biochemical assays and cellular biology research. -
Ferroptosis Inhibitor
1(R)-(Trifluoromethyl)oleyl alcohol is a trifluoromethyl alcohol derivative of oleic acid that functions as a ferroptosis inhibitor. This compound effectively attenuates ferroptosis induced by Erastin and mitigates lipid peroxidation in human myoblasts with frataxin (FXN) siRNA knockdown. At a concentration of 40 μM, it enhances cell survival to 95% in models of Friedreich ataxia where cell death is largely driven by iron accumulation and glutathione depletion. This makes 1(R)-(Trifluoromethyl)oleyl alcohol a valuable reagent for studying ferroptosis and its related pathways in neurodegenerative diseases. -
Ferroptosis Inhibitor
Ferroptosis-IN-3 is a potent ferroptosis inhibitor targeting the ferroptotic cell death pathway. It effectively inhibits RSL3-induced ferroptosis in HT-1080 cells with an EC50 of 8.6 nM. Additionally, Ferroptosis-IN-3 demonstrates strong free radical scavenging properties, with EC50 values of 3.94 μM for DPPH and 6.3 μM for ABTS, and reduces lipid peroxidation. This compound is ideal for research focused on oxidative stress and cell death mechanisms. -
Glyceraldehyde Derivative
TOFA-Plasmalogen is a glyceraldehyde derivative that induces ferroptosis through the promotion of lipid peroxidation on cellular membranes. This compound exhibits cytotoxic effects with an IC50 of 32.87 μM. TOFA-Plasmalogen is valuable for research applications focused on understanding the mechanisms of cell death and oxidative stress-related disorders. -
Ferroptosis Inhibitor
Ferroptosis Inducer-6 is a potent inducer of ferroptosis, primarily functioning through the generation of reactive oxygen species (ROS) and the induction of oxidative stress and mitochondrial damage. This compound exhibits anti-tumor activity and serves as a valuable tool for research in type I and II photodynamic therapy. Its ability to trigger ferroptotic cell death makes it significant for studies focused on cancer treatment and exploring the mechanisms of cell death pathways. -
Ferroptosis Inducer
Lepadin E is a potent ferroptosis inducer that activates cell death through the classical p53-SLC7A11-GPX4 pathway. By promoting p53 expression and downregulating SLC7A11 and GPX4, Lepadin E enhances reactive oxygen species (ROS) and lipid peroxide production while increasing ACSL4 expression. This mechanism underlies its significant antitumor efficacy, making Lepadin E a valuable tool for studying ferroptosis in cancer research. -
Ferroptosis Inhibitor
Ferroptosis-IN-11 is a potent ferroptosis inhibitor targeting the pathways involved in iron-mediated cell death. It effectively inhibits Erastin-induced ferroptosis in HT-1080 human fibroblasts, demonstrating an EC50 of 36 nM. This compound is valuable for research into cardiovascular diseases and neurodegenerative disorders, providing insights into the mechanisms of ferroptosis and potential therapeutic strategies. -
Ferroptosis/MAO-B Inhibitor
MAO-B-IN-45 is a selective inhibitor of MAO-B with an IC50 of 87.47 nM, demonstrating over 229-fold selectivity for MAO-B compared to MAO-A. This compound exhibits significant antiferroptosis activity by modulating the iron metabolic pathway and the glutathione peroxidase 4 (GPX4) axis in vitro. Research indicates that MAO-B-IN-45 enhances cognitive and behavioral functions in 3×Tg (APP/Tau/Ps1) Alzheimer's disease mouse models, while also reducing levels of ferritin heavy chain 1 (FTH1), amyloid precursor protein (APP), and phosphorylated Tau (p-Tau) in the brain. -
Ferroptosis/Apoptosis Inducer
Lepadin H is a potent ferroptosis and apoptosis inducer, demonstrating significant in vitro cytotoxicity and in vivo antitumor efficacy against cancer cells. This compound functions by decreasing the levels of GPX4 and SLC7A11, while enhancing p53 and ACSL4 expression. Lepadin H promotes the generation of lipid hydroperoxides and increases reactive oxygen species (ROS), leading to a reduction in cellular glutathione (GSH) levels and lipid peroxidation. Additionally, it causes G2/M phase cell cycle arrest and inhibits the clonogenic growth and migration of melanoma cells, making it a valuable tool for cancer research. -
Ferroptosis Inducer
AX-53802 is a potent ferroptosis inducer that targets glutathione peroxidase 4 (GPX4) with an IC50 value of 0.34 µM. This compound covalently binds to GPX4, facilitating membrane translocation and subsequent triggering of ferroptotic cell death. In combination with FAK/Src inhibitors, AX-53802 enhances the induction of cell death, making it a valuable tool for cancer research and studies involving ferroptosis mechanisms. -
Ferroptosis Inducer
Ferroptosis inducer-7 selectively induces ferroptosis via the inositol 1,4,5-trisphosphate receptor (IP3R) and calcium release-activated calcium channel protein (ORAI). This compound demonstrates significant biological activity in alleviating symptoms of anemia, suppressing activation of bone marrow cytotoxic T lymphocytes (CTLs), and enhancing hematopoietic function in cases of immune-mediated bone marrow failure. Ferroptosis inducer-7 is valuable for research applications focused on aplastic anemia and related hematological conditions. -
Ferroptosis Inhibitor
Ferrostatin-1 diyne is a potent ferroptosis inhibitor that selectively targets the ferroptotic pathway. This compound is known to accumulate in lysosomes, mitochondria, and the endoplasmic reticulum of cells. Notably, its inhibition of ferroptosis occurs independently of lysosomal and mitochondrial activity, making it a valuable tool for studying ferroptosis-related mechanisms and evaluating therapeutic strategies in various research applications. -
Ferroptosis Inducer
Anticancer agent 147 is a ferroptosis inducer that promotes intracellular accumulation of Fe2+, reactive oxygen species (ROS), and malondialdehyde (MDA). This compound enhances endoplasmic reticulum (ER) stress and upregulates the expression of activating transcription factor ATF3. Anticancer agent 147 exhibits significant anti-liver cancer effects in both in vitro and in vivo models, making it a valuable tool for research in cancer therapy and cell death mechanisms. -
Ferroptosis Inhibitor
RC574 is a novel ferroptosis inhibitor that protects mouse hippocampal cells and primary cortical neurons from glutamate-induced oxidative cell death. It enhances levels and activity of glutathione peroxidase 1 (GPx1), vital for cellular antioxidant defense. This compound is valuable for research into neuroprotection and the mechanisms underlying ferroptosis in neurodegenerative diseases. -
Apoptosis/Ferroptosis Inducer
GIC-20 is a dual inducer of apoptosis and ferroptosis, acting on key cellular pathways involved in programmed cell death. This compound demonstrates significant antitumor efficacy, particularly against fibrosarcoma. GIC-20 is valuable for research applications aimed at exploring mechanisms of cell death and potential therapeutic strategies in cancer biology. -
Ferroptosis Inducer
Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III) acts as a ferroptosis inducer by generating lipid-based reactive oxygen species (ROS). This compound is instrumental for research exploring the mechanisms of ferroptosis, a form of regulated cell death characterized by iron-dependent lipid peroxidation. It is valuable for studies investigating cancer biology, neurodegenerative diseases, and other conditions where ferroptosis plays a critical role. -
Ferroptosis Inhibitor
Ferroptosis-IN-4 is a potent ferroptosis inhibitor, exhibiting an EC50 value of 20 μM. This compound demonstrates minimal cytotoxicity, highlighting its safety for biological applications. Ferroptosis-IN-4 provides a protective effect in models of glycerol-induced renal acute kidney injury (RM-AKI), effectively alleviating kidney dysfunction. Its ability to modulate ferroptosis makes it a valuable tool for research in cellular stress responses and kidney-related disorders. -
Ferroptosis Inducers
Ferroptocide is a potent inducer of ferroptosis, a form of regulated cell death characterized by iron-dependent lipid peroxidation. It effectively induces oxidative stress, resulting in G2/M cell cycle arrest and apoptosis in LNCaP cells, and significantly reduces cell viability in both LNCaP and TRAMP-C1 prostate cancer cell lines. Ferroptocide serves as a valuable tool for investigating mitochondrial autophagy and evaluating its potential to trigger immunogenic cell death (ICD) in prostate cancer research.
