Catalog No.
Product Name
Application
Product Information
Citations
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Stable Isotope
Diethylstilbestrol-d3 is a deuterium-labeled derivative of Diethylstilbestrol, a synthetic nonsteroidal estrogen. This stable isotope can be utilized in various biochemical and pharmaceutical research applications, including metabolic studies and the investigation of estrogen receptor interactions. Its use enhances the understanding of pharmacokinetics and dynamics of estrogenic compounds in biological systems. -
Stable Isotope
Estradiol benzoate-d3 is a deuterium-labeled derivative of Estradiol benzoate, a proagent of the steroid sex hormone estradiol. This compound possesses mild anabolic and metabolic properties, influencing various physiological processes, including enhancing blood coagulability. It is primarily utilized in research applications focused on hormone activity, steroid metabolism, and the effects of estradiol in biological systems. -
Stable Isotope
α-Zearalenol-d4 is a deuterated isotope of α-Zearalenol, a mycotoxin known for its strong affinity for estrogen receptors. As a derivative of zearalenone, it demonstrates significant xenoestrogenic properties that can lead to reproductive disorders in various animal models. This stable isotope is valuable for biochemical and pharmacological studies involving estrogen receptor signaling and mycotoxin metabolism. -
Stable Isotope
Estradiol valerianate-d4 is a deuterium-labeled derivative of Estradiol valerianate, a synthetic estrogen. It plays a crucial role in hormone replacement therapy by providing a stable isotope for metabolic studies and tracer applications. The compound is essential in understanding estrogen metabolism and dynamics in biological systems. -
Stable Isotope
Raloxifene 4'-glucuronide-d4 is a deuterated stable isotope of Raloxifene 4'-glucuronide, a primary metabolite of Raloxifene. This compound is primarily formed through the action of UGT1A10 and UGT1A8 enzymes. Raloxifene 4'-glucuronide exhibits binding to the estrogen receptor with an IC50 of 370 μM. It functions as a selective estrogen receptor modulator, activating the TGFβ3 promoter as a full agonist at nanomolar concentrations while also inhibiting expression from the estrogen response element-containing vitellogenin promoter. This makes it a valuable tool for studying estrogen receptor activity and metabolism in chemical research. -
Stable Isotope
(Rac)-Zearalanone-d6 is a stable isotope of the mycotoxin Zearalanone, a nonsteroidal estrogenic compound produced by Fusarium species commonly found in various grains. This compound acts as an estrogen receptor agonist, demonstrating significant estrogenic and anabolic effects across multiple animal species, which can adversely impact the reproductive system. (Rac)-Zearalanone-d6 can be used for research applications involving environmental monitoring, toxicology studies, and investigations into estrogenic activity in biological systems. -
Stable Isotope
Zeranol-d5 (mixture of diastereomers) is a deuterium-labeled derivative of Zeranol, acting as an estrogen receptor agonist. This compound is primarily utilized in research examining estrogenic activity and its effects on growth promotion in livestock. Its stable isotope nature allows for precise tracking in metabolic studies and contributes to understanding the role of mycoestrogens in environmental and health-related contexts. -
Stable Isotope
Bazedoxifene-d4 is a deuterium-labeled analog of Bazedoxifene, a nonsteroidal selective estrogen receptor modulator (SERM) that exhibits a potent affinity for estrogen receptors ERα and ERβ, with IC50 values of 23 nM and 99 nM, respectively. This compound is utilized in research focused on osteoporosis and has been shown to inhibit IL-6/GP130 protein-protein interactions, making it relevant for studies related to pancreatic cancer. Its stable isotope labeling facilitates advanced metabolic and pharmacokinetic investigations. -
Stable Isotope
Dienestrol-d2 is a deuterium-labeled derivative of Dienestrol, functioning as a stable isotope. This compound can be utilized in quantitative analytical techniques, such as liquid chromatography-mass spectrometry (LC-MS), to study the pharmacokinetics and metabolism of estrogens. Its unique isotopic labeling enhances sensitivity and specificity in biological research applications. -
Stable Isotope
(Rac)-Hexestrol-d6-1 is a deuterium-labeled derivative of the synthetic non-steroidal estrogen, (Rac)-Hexestrol. It serves as a stable isotope for use in various biological and chemical research applications, including metabolic studies and pharmacokinetic investigations. This compound aids in understanding the behavior and mechanisms of estrogen-related processes in different biological systems. -
Stable Isotope
17-Epiestriol-d5-1 is a deuterated form of 17-Epiestriol, a selective estrogen receptor (ER) β agonist. This compound functions as an effective inhibitor of vascular cell adhesion molecule VCAM-1 expression induced by tumor necrosis factor α (TNFα) and prevents the nuclear translocation of NF-κB. Additionally, 17-Epiestriol-d5-1 promotes the expression of endothelial nitric oxide synthase at both mRNA and protein levels. It serves as a valuable tool in research exploring estrogen receptor signaling and its implications in cardiovascular and inflammatory responses. -
Stable Isotope
Bazedoxifene-d4 acetate is a deuterium-labeled form of Bazedoxifene, a nonsteroidal selective estrogen receptor modulator (SERM) that demonstrates potent activity against estrogen receptors ERα and ERβ with IC50 values of 23 nM and 99 nM, respectively. This stable isotope is valuable for research involving osteoporosis and also serves as an inhibitor of IL-6/GP130 protein-protein interactions, making it relevant for studies in pancreatic cancer. -
Stable Isotope
Raloxifene-d10-1 is a deuterium-labeled derivative of Raloxifene, a selective estrogen receptor modulator (SERM) derived from benzothiophene. It exhibits estrogen-agonistic activity on bone and lipid metabolism while antagonizing estrogen receptors in breast and uterine tissues. This compound is crucial for research involving breast cancer and osteoporosis, facilitating studies on the pharmacokinetics and pharmacodynamics of Raloxifene and its effects in various biological contexts. -
Stable Isotope
Clomiphene-d5 citrate is a deuterium-labeled form of Enclomiphene citrate, a potent oral estrogen receptor antagonist. Its antioestrogenic properties make it valuable for studying estrogen signaling pathways and reproductive health. This stable isotope is an essential tool for biochemical research that requires precise tracking of metabolic pathways and pharmacokinetics involving Clomiphene. -
Stable Isotope
Norethindrone-d6 is a deuterated form of Norethindrone, a progestin used clinically for managing conditions such as endometriosis, abnormal uterine bleeding, and secondary amenorrhea. As a stable isotope, Norethindrone-d6 serves as a valuable tool in metabolic studies and tracing applications. This compound features an alkyne functionality, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing compounds, facilitating the synthesis of complex bioconjugates and polymers in chemical research. -
Stable Isotope
Norgestrel-d6 is a deuterium-labeled derivative of Levonorgestrel, a synthetic progestogen commonly utilized in hormonal contraceptives. This compound serves as a stable isotope and is a valuable click chemistry reagent featuring an alkyne group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. Its applications span various biochemical research fields, enhancing the investigation of metabolic pathways and drug interactions. -
Stable Isotope
Medroxyprogesterone-d3 is a deuterium-labeled derivative of Medroxyprogesterone, a synthetic progestin and a potent agonist of the progesterone receptor. This stable isotope is utilized in various research applications, including pharmacokinetic studies, hormonal regulation investigations, and the development of analytical methods for progesterone-related compounds. Its use enhances the understanding of progestin interactions and metabolism in biological systems. -
Stable Isotope
Drospirenone-d4 is the deuterated form of Drospirenone, a synthetic progestin structurally related to spironolactone. This stable isotope is utilized primarily in pharmacokinetic studies and metabolic research to trace drug activity in biological systems. Its deuterium labeling allows for enhanced detection and quantification in complex biological matrices. -
Stable Isotope
Gestodene-d6 is a deuterium-labeled derivative of the progestogen hormonal contraceptive, Gestodene. This stable isotope serves as a valuable tool in click chemistry applications, featuring an alkyne functionality that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its unique properties make it suitable for various biochemical research applications, including metabolic labeling, drug development, and tracking biological processes. -
Stable Isotope
Norgestimate-d6 is a deuterium-labeled form of Norgestimate, a synthetic progestin that exhibits selective progestational activity with minimal androgenic effects. It is utilized primarily in oral contraceptive formulations. Norgestimate-d6 serves as a valuable tool in click chemistry applications, containing an alkyne functional group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules, facilitating the synthesis of complex bioconjugates for chemical biology research. -
Stable Isotope
Methimazole-d3 is a deuterium-labeled derivative of Methimazole, an anti-thyroid agent that inhibits thyroid hormone synthesis in the thyroid gland. This stable isotope is valuable for biochemical studies, including pharmacokinetic and metabolic research. Methimazole has also been associated with hepatotoxicity, making Methimazole-d3 an important tool for studying its effects and mechanisms in metabolic processes. -
Stable Isotope
Liothyronine-13C6-1 is a stable isotope-labeled form of Liothyronine, which serves as a potent agonist for thyroid hormone receptors TRα and TRβ, exhibiting inhibition constants (Kis) of 2.33 nM for both receptors. This reagent is valuable for research applications involving thyroid hormone signaling, metabolic studies, and metabolic disorders. Its isotopic labeling allows for enhanced tracking and quantification in various analytical techniques, facilitating investigations into hormone receptor activity and related biological pathways. -
Stable Isotope
Reverse T3-13C6 hydrochloride is a stable isotope-labeled form of Reverse T3, featuring six carbon-13 isotopes. This compound is primarily utilized in metabolic studies and tracer experiments, allowing for the quantification and analysis of thyroid hormone metabolism. Its stable isotope labeling enhances sensitivity and accuracy in various biological and biochemical research applications. -
Stable Isotope
Paricalcitol-d6 is a deuterium-labeled form of Paricalcitol, targeting the modulation of parathyroid hormone secretion. It is utilized in the prevention and treatment of secondary hyperparathyroidism, particularly in patients with chronic renal failure. Paricalcitol-d6 serves as a valuable stable isotope for research applications focusing on metabolic studies and pharmacokinetics of calcimimetics in kidney disease. -
Stable Isotope
Difethialone-d4 is a deuterium-labeled analogue of the anticoagulant rodenticide difethialone. This compound inhibits vitamin K metabolism in the liver, leading to impaired synthesis of coagulation factors and resulting in bleeding disorders in rodent populations. Difethialone-d4 is utilized in research to investigate the ecological effects of rodenticide applications and to study the pharmacokinetics and dynamics of difethialone in various biological systems. -
Stable Isotope
Coumachlor-d4 is a deuterium-labeled form of Coumachlor, a vitamin K antagonist known for its oral anticoagulant properties. This stable isotope is valuable for tracking and quantifying Coumachlor in metabolic studies and pharmacokinetic research. It is utilized in studies investigating the mechanisms of action of anticoagulants and their effects on coagulation pathways. -
Stable Isotope
Phenprocoumon-d5 is a deuterated version of Phenprocoumon, a coumarin derivative that functions as a long-acting oral anticoagulant and vitamin K antagonist. This stable isotope is valuable for pharmacokinetic studies and metabolic research, enabling precise tracking of compound behavior in biological systems. Its deuterium labeling supports advanced analytical techniques, making it an essential tool for researchers focusing on anticoagulant therapy and coagulation studies. -
Stable Isotope
(1S)-Calcitriol-d6 is a stable isotope-labeled form of (1S)-Calcitriol, also known as 1α,25-Dihydroxy-3-epi-vitamin D3-d6. This compound primarily targets the vitamin D receptor (VDR), exhibiting significant biological activities, including the inhibition of keratinocyte proliferation and the suppression of parathyroid hormone secretion. It is suitable for various research applications, particularly in studies related to vitamin D metabolism and its physiological effects. -
Stable Isotope
(1S)-Calcitriol-d3 is a deuterated form of (1S)-Calcitriol, a natural metabolite of 1α,25-dihydroxyvitamin D3. This stable isotope serves as a valuable tool for tracing and quantifying vitamin D metabolism and interactions. (1S)-Calcitriol-d3 exhibits significant biological activity through its potent engagement with the vitamin D receptor (VDR), promoting the inhibition of keratinocyte proliferation and the suppression of parathyroid hormone secretion. It is ideally suited for research applications in endocrinology, dermatology, and metabolic studies related to vitamin D signaling. -
Stable Isotope
Fmoc-Gly-OH-d2 is a deuterium-labeled derivative of Fmoc-protected glycine, serving as a stable isotope in chemical research. It plays a crucial role in synthetic chemistry, particularly in the preparation of peptide and other complex compounds. This reagent is particularly useful for studies involving mass spectrometry and tracking the dynamics of biological processes. -
Stable Isotope
N-Valerylglycine-d2 is a deuterated analog of N-Valerylglycine, serving as a stable isotope in scientific research. This compound, a derivative of glycine, is primarily utilized in metabolic studies and isotopic labeling experiments. Its unique properties enable enhanced tracking of biochemical pathways and facilitate the investigation of various physiological processes. -
Stable Isotope
Fmoc-L-Val-OH-d8 is a deuterium-labeled derivative of Fmoc-L-Val-OH, serving as a stable isotope for research applications. This compound is utilized primarily in the synthesis of protected amino acids, which are essential for peptide chemistry. Its stable isotopic labeling facilitates detailed characterization of peptides and proteins in various analytical studies, including mass spectrometry and NMR spectroscopy. -
Stable Isotope
N-Heptanoylglycine-d2 is a stable isotope-labeled derivative of N-Heptanoylglycine. This compound serves as a valuable tool in metabolic studies and isotopic tracing applications, allowing for enhanced understanding of glycine metabolism. Its incorporation of deuterium enables precise tracking in various biological systems, facilitating research in neuropharmacology and other fields focused on amino acid derivatives. -
Stable Isotope
Fmoc-Gly-OH-15N is a stable isotope-labeled derivative of Fmoc-glycine, featuring nitrogen-15 (15N) isotopes. This compound serves as a tool for the synthesis of peptide and protein constructs, particularly in studies requiring isotopic labeling. Its use in research facilitates the investigation of protein dynamics and interactions through NMR spectroscopy and other analytical techniques. -
Stable Isotope
Fmoc-Gly-OH-13C2,15N is a stable isotope-labeled derivative of Fmoc-protected glycine, incorporating both 15N and 13C isotopes. This compound serves as a valuable building block for the synthesis of various biomolecules, facilitating studies in peptide chemistry and other biochemical research applications. Its isotopic labeling enables precise tracking and analysis in metabolic studies and NMR investigations. -
Stable Isotope
N-Valerylglycine-13C2,15N is a stable isotope-labeled derivative of N-Valerylglycine, containing two carbon-13 and one nitrogen-15 isotope. This compound serves as a valuable tool in metabolic studies and tracer experiments, enabling precise quantification and tracking of metabolic pathways. It is particularly useful in proteomics and applications involving stable isotope labeling for cellular metabolism analysis. -
Stable Isotope
Alitame-d3 is a deuterium-labeled derivative of Alitame, a high-intensity sweetener synthesized from L-aspartic acid, D-alanine, and a thietane-derived amine. This stable isotope serves as an invaluable tool in metabolic studies and tracer experiments, facilitating the investigation of sweetener metabolism and its impact on biological systems. Researchers can utilize Alitame-d3 for precise quantitative analysis in various applications, including nutrition and pharmacokinetics. -
Stable Isotope
Fmoc-Gly-OH-13C is a stable isotope-labeled derivative of Fmoc-glycine, specifically incorporating 13C. This reagent serves as a versatile building block in peptide synthesis, providing a means to incorporate stable isotopes for mechanistic studies and metabolic tracking in biological research. Its applications extend to isotopic labeling experiments, aiding in the elucidation of metabolic pathways and protein dynamics. -
Stable Isotope
Fmoc-Gly-OH-2-13C,15N is a stable isotope-labeled derivative of Fmoc-protected glycine, specifically enriched with 13C and 15N. This compound is essential for studies involving peptide synthesis and can be utilized in various biochemical applications, including NMR spectroscopy and mass spectrometry. Its stable isotopic labeling enhances the detection and quantification of glycine in complex mixtures, making it a valuable tool in metabolic and structural biology research. -
Stable Isotope
N-Formylglycine ethyl ester-13C2 is a stable isotope-labeled derivative of N-Formylglycine ethyl ester. This compound serves as a valuable tool in metabolic studies and tracer experiments, enabling researchers to investigate glycine metabolism and enzymatic processes involving this amino acid. Its isotopic labeling allows for enhanced analytical sensitivity and specificity in various biological applications, making it an essential reagent for studies in biochemistry and cellular biology. -
Stable Isotope
DL-Phenylmercapturic Acid-13C6 is a stable isotope-labeled analog of DL-Phenylmercapturic Acid, also known as N-Acetyl-S-phenyl-L-cysteine-13C6. This cysteine derivative is useful for metabolic studies as it allows the tracing of sulfur-containing compounds in biological systems. Its applications include pharmacokinetics, toxicology research, and exploring mechanisms of drug metabolism. -
Stable Isotope
Boc-D-Chg-OH-d11 is a deuterated form of Boc-D-Chg-OH, functioning as a stable isotope-labeled compound. This derivative of glycine is valuable in various biochemical applications, particularly in studies involving metabolic pathways and tracer kinetics. Its labeling with deuterium enhances tracking capabilities in mass spectrometry and NMR experiments, supporting advanced research in chemical biology and proteomics. -
Stable Isotope
H-N-Me-Ala-OH-13C,d3 is a stable isotope-labeled derivative of N-Methyl-L-alanine. This compound features both deuterium and carbon-13 isotopes, making it valuable for precision tracing and quantification in metabolic studies. Its applications include research in amino acid metabolism and protein synthesis, enabling insights into cellular processes and metabolic pathways. -
Stable Isotope
Methyl 2-aminoacetate hydrochloride-13C2,15N is a stable isotope-labeled derivative of Methyl 2-aminoacetate hydrochloride, featuring both carbon-13 and nitrogen-15 isotopes. This compound is primarily utilized in metabolic studies and tracer experiments to investigate amino acid metabolism and biosynthesis pathways. Its isotopic labeling enhances detection and quantification in various analytical techniques, making it a valuable tool for researchers in biochemical and physiological studies. -
Stable Isotope
N-(9-Fluorenylmethoxycarbonyl)glutamic acid α-tert-butyl ester-13C5,15N is a stable isotope-labeled derivative of N-(9-Fluorenylmethoxycarbonyl)glutamic acid α-tert-butyl ester. This compound incorporates five carbon-13 and one nitrogen-15 isotopes, making it valuable for metabolic labeling and tracking in biological studies. It is applicable in research involving glutamate signaling pathways and can enhance the understanding of protein dynamics in cellular systems. -
Stable Isotope
Fmoc-Gly-OH-13C2 is a stable isotope-labeled variant of Fmoc-glycine, featuring two carbon-13 isotopes. This Fmoc-protected glycine derivative is essential for the synthesis of various compounds in the pharmaceutical and chemical research domains. Its isotopic labeling facilitates advanced analytical techniques such as NMR spectroscopy and mass spectrometry, enhancing the study of molecular interactions and dynamics. -
Stable Isotope
N-Fmoc-L-isoleucine-d10 is a deuterated derivative of Fmoc-D-Allo-Ile-OH, featuring a stable isotope substitution that enhances its utility in various research applications. This compound serves as a valuable tool for peptide synthesis and isotope labeling studies, enabling detailed analysis of metabolic pathways and protein dynamics. Its stable isotope labeling allows for advanced techniques such as NMR spectroscopy and mass spectrometry in proteomic research. -
Stable Isotope
2,2-Dibromomalonamide-13C3 is a stable isotope-labeled form of 2,2-Dibromomalonamide. This compound serves as a useful biochemical agent in various research applications, including metabolic studies and isotopic tracing experiments. The incorporation of the 13C label enables precise tracking of metabolic pathways and facilitates the investigation of biochemical interactions. -
Stable Isotope
Ioxitalamic acid-d4 is a deuterated form of Ioxitalamic acid, serving as a stable isotope. This compound functions as a water-soluble, nephrophilic X-ray iodinated contrast agent, known for its high permeability. It is particularly useful in imaging studies and investigations involving renal function, enhancing the resolution and specificity of diagnostic procedures. -
Stable Isotope
1-(Methyl-d3)-4-nitrosopiperazine is a deuterated analog of 1-Methyl-4-nitrosopiperazine, commonly used as a stable isotope. This compound serves as a valuable internal standard in analytical chemistry, particularly in the identification and quantification of potential impurities in pharmaceuticals such as sartans, non-steroidal anti-inflammatory drugs (NSAIDs), and thiazide diuretics. Its application in research ensures accuracy and reliability in monitoring nitrosamine levels in drug formulations.
