Isotope-Labeled Compounds

DL-3-Phenylalanine-13C-2 is a stable isotope-labeled form of DL-3-Phenylalanine, which is a derivative of phenylalanine. This compound is primarily used in metabolic studies and tracer experiments due to its ability to trace metabolic pathways and protein synthesis in biological systems. Its incorporation of the stable isotope carbon-13 allows for precise tracking and quantification in various research applications, including amino acid metabolism and nutritional studies.

DL-3-Phenylalanine-d2 is a deuterium-labeled derivative of DL-3-Phenylalanine, serving as a stable isotope. It is primarily used in metabolic and biochemical research, particularly in studies involving protein synthesis and amino acid metabolism. This reagent facilitates isotopic tracing studies and enhances quantification accuracy in mass spectrometry applications.

Fmoc-L-Val-OH-13C5,15N is a stable isotope-labeled derivative of valine, featuring both 15N and 13C isotopes. This compound is primarily used in NMR spectroscopy and mass spectrometry for metabolic studies, allowing researchers to trace metabolic pathways and protein dynamics with enhanced resolution. Its isotopic labeling provides a powerful tool for structural analysis and functional studies in chemical research and biochemistry.

2-Amino-3-mercaptopropanoic acid-d2 is a deuterated form of 2-Amino-3-mercaptopropanoic acid, a key cysteine derivative. This stable isotope is utilized in metabolic and labeling studies to trace biochemical pathways involving sulfur-containing amino acids. Its unique isotopic properties enhance the sensitivity and accuracy of various analytical techniques in chemical and biological research.

N-Formyl-L-leucine-d3 is a deuterium-labeled derivative of N-Formyl-L-leucine, targeting stable isotope applications in biochemical research. This compound serves as a valuable tool for tracer studies, allowing for the investigation of metabolic pathways and protein synthesis involving leucine derivatives. Its isotopic labeling enables enhanced detection and quantification in mass spectrometry and other analytical techniques.

Fmoc-His(Trt)-OH-15N3 is a stable isotope-labeled derivative of histidine, specifically designed for use in peptide synthesis. The trityl (Trt) group protects the side chain of histidine, while the Fmoc group safeguards the α-NH2 group, ensuring high fidelity during solid-phase peptide synthesis. This reagent is ideal for studies requiring precise tracking of peptide dynamics or interactions in biological systems. Its use mitigates racemization and minimizes by-product formation, enhancing the overall quality of synthesized peptides.

Fmoc-Gln(Trt)-OH-13C5,15N2 is a stable isotope-labeled derivative of Fmoc-Gln(Trt)-OH, incorporating five carbon-13 and two nitrogen-15 isotopes. This compound features a protective Fmoc (9-fluorenylmethoxycarbonyl) group attached to the glutamine residue, making it suitable for solid-phase peptide synthesis. Its isotopic labeling facilitates studies in protein dynamics, metabolism, and tracer experiments in biochemical and biophysical research.

(((9H-Fluoren-9-yl)methoxy)carbonyl)-L-aspartic acid-15N is a stable isotope-labeled derivative of L-aspartic acid, specifically designed for use in metabolic studies and tracer experiments. This compound retains the protective fluorenylmethoxycarbonyl (Fmoc) group, facilitating its application in peptide synthesis and biochemical assays. The incorporation of the nitrogen-15 isotope enables researchers to trace metabolic pathways and study nitrogen-related processes in various biological systems.

Boc-L-Valine-15N is a stable isotope-labeled derivative of Boc-L-Valine, containing nitrogen-15 (15N). This compound is frequently utilized in research involving mass spectrometry and NMR spectroscopy for tracking metabolic pathways and protein synthesis. Its incorporation into experimental designs aids in understanding amino acid metabolism and protein interactions.

Methyl heptadecanoate-d33 is a deuterium-labeled stable isotope of methyl heptadecanoate, the methyl ester of heptadecanoic acid. This reagent serves as an internal standard for the quantitative analysis of fatty acids using gas chromatography-mass spectrometry (GC-MS). Its distinct isotopic signature enhances the accuracy and reliability of fatty acid quantification in various research applications, including metabolic studies and lipidomics.

MES-d13 is a deuterated form of 2-Morpholinoethanesulphonic acid (MES), a widely used amphoteric ion buffer with an effective pH range of 5.5 to 7.0. Its properties make it suitable for various biochemical and molecular biology applications, including cell culture, enzyme activity assays, electrophoresis, and protein analysis. The stable isotope labeling allows for enhanced tracking and quantification in metabolic studies and other research settings.

Dansyl chloride-d6 is a deuterium-labeled derivative of dansyl chloride, serving as a stable isotope reagent. It is primarily utilized to generate fluorescent sulfonamide adducts through reactions with aliphatic and aromatic amines containing primary amino groups. This compound is instrumental in protein sequencing, modified amino acid studies, and comprehensive amino acid analysis, offering enhanced tracking and sensitivity in fluorescent applications.

1,3-Diphenylguanidine-d10 is a deuterated form of 1,3-Diphenylguanidine, serving as a stable isotope label. This compound is primarily utilized as an accelerator in the vulcanization process of rubber, contributing to improvements in elasticity and durability. It is essential for research applications focused on rubber formulation and polymer chemistry.

Terephthalic acid-13C2 is a stable isotope-labeled variant of terephthalic acid. It serves as a key precursor in the synthesis of polyethylene terephthalate (PET), a widely used polymer in textiles and plastics. Additionally, Terephthalic acid-13C2 is valuable in the development of skin tumor models, facilitating research into cancer biology and pharmacology.

Triacetonamine-d17 is a deuterium-labeled form of Triacetonamine, serving as a stable isotope for various research applications. This compound is notable for its oral activity and potential to induce acute liver failure (ALF) in animal models, specifically in rats. It is relevant for studies investigating liver toxicity and metabolic pathways, providing a valuable tool for researchers exploring hepatic function and drug metabolism.

N-Methylpyrrolidone-d9 is a deuterated form of N-Methylpyrrolidone (NMP), a five-membered cyclic amide known for its polar solvent properties. This stable isotope serves as a valuable tracer in chemical research and analysis. It is extensively utilized in various applications, including the study of solvent-solute interactions, formulation development in pharmaceuticals, and the investigation of teratogenic effects in safety studies.

4-Iodoaniline-13C6 is a stable isotope-labeled derivative of 4-Iodoaniline, acting as a potent methemoglobin former. This compound serves as an important intermediate for the synthesis of glycogen phosphorylase inhibitors and is utilized in research focused on liver cancer and hematological disorders. The 13C labeling allows for enhanced tracking and analysis in various biochemical applications.

Phthalaldehyde-d6 is a deuterium-labeled derivative of phthalaldehyde, a key reagent utilized in biochemical assays. This compound selectively reacts with amino acids, enabling the derivatization and subsequent measurement of the resulting fluorescent products through high-performance liquid chromatography (HPLC). Its stable isotope labeling enhances the sensitivity and accuracy of analytical applications in biochemical studies and metabolic analysis.

4,4'-Sulfonyldiphenol-13C12 is a stable isotope-labeled variant of 4,4'-sulfonyldiphenol, commonly known as Bisphenol S. This compound serves as a useful biochemical reagent in life science research, facilitating studies related to endocrine disruption and polymer synthesis. Its incorporation of carbon-13 enables advanced analytical techniques such as NMR and mass spectrometry to trace metabolic pathways and environmental interactions of Bisphenol S in various biological systems.

5-Methyl-1H-benzotriazole-d6 is a deuterium-labeled derivative of 5-Methyl-1H-benzotriazole, serving as a stable isotope. This compound is valuable in life science research for applications such as tracing and quantifying metabolites in metabolic studies and aiding in the elucidation of biological pathways. Its unique labeling enhances the precision and accuracy of analytical techniques, making it an essential tool for chemical research.

Terephthalic acid-d4 is a deuterium-labeled derivative of terephthalic acid, primarily utilized as a stable isotope. This compound serves as a precursor in the synthesis of polyethylene terephthalate (PET), which is widely used in textile and plastic manufacturing. Terephthalic acid-d4 can also be employed in the development of skin tumor models, aiding in cancer research and therapeutic studies.

2-Naphthoic acid-13C6 is a stable isotope-labeled form of 2-Naphthoic acid, primarily utilized in chemical research for tracing and quantification applications. This compound serves as a versatile raw material for the synthesis of dyes and other organic chemicals, facilitating critical research in textile, printing, and manufacturing industries. Additionally, it is employed in the development of photosensitive materials and lubricants, contributing to advancements in material science and engineering.

MTSSL-15N,d15 is a deuterium and 15N-labeled variant of the reactive thiol-specific spin label MTSSL. This compound serves as an effective tool for labeling protein thiol residues, facilitating studies on protein structure, dynamics, and protein-protein interactions. Its stable isotope labeling enhances the precision of experimental results in biochemical and biophysical research applications.

1-Bromo-3-iodobenzene-d4 is a deuterated form of 1-Bromo-3-iodobenzene, serving as a stable isotope labeled biochemical reagent. This compound is valuable in organic synthesis, facilitating the formation of other active compounds. It is particularly useful in tracing studies and monitoring metabolic pathways in biochemical research.

5-Aminopyrimidine-d3 is a stable isotope of 5-Aminopyrimidine, a significant biochemical reagent widely used in life sciences research. This compound serves as a precursor for various derivatives that exhibit antioxidant activity. It is valuable for studying metabolic pathways and interactions in biochemical assays, enabling precise tracking in isotopic labeling experiments.

Ceramide 3-d3 (N-Stearoyl phytosphingosine-d3) is a deuterated form of Ceramide 3, a bioactive sphingolipid notably present in the stratum corneum of Saccharomyces cerevisiae, wheat grain, and mammalian epidermis. With a phytosphingosine backbone linked to a C18 fatty acid chain, Ceramide 3-d3 plays a crucial role in regulating apoptosis and cell differentiation, while also supporting smooth muscle cell proliferation and inhibiting the mitochondrial respiratory chain. Furthermore, it suppresses the expression of pro-inflammatory cytokines IL-4 and TNF-α, as well as transcription factors c-Jun and NF-κB in histone-stimulated mouse skin tissue, making it valuable for research in skin health and inflammation.

Benzene-1,3,5-tricarboxylic acid-d3 is a deuterated form of Benzene-1,3,5-tricarboxylic acid, commonly known as trimesic acid, serving as a stable isotope-labeled scaffold. This compound enhances the binding affinity of bicyclic peptides to target proteins and contributes to the mechanical stability of hydrogels. It is useful in various research applications, including synthetic biology, drug development, and biomaterials science, facilitating studies on protein interactions and material properties.

Methyl heptanoate-d13 is a deuterium-labeled stable isotope of Methyl heptanoate, primarily utilized in analytical chemistry and metabolic research. This compound serves as a valuable tracer in studies involving flavor and fragrance components, as well as in the analysis of solvent behavior with resins, oils, and waxes. Additionally, Methyl heptanoate-d13 has applications in biofuel research and polymer production, facilitating the investigation of metabolic pathways and product synthesis in various scientific fields.

Linolenic acid glycidyl ester-d5 is a deuterium-labeled derivative of linolenic acid glycidyl ester. This stable isotope compound can be utilized in various biochemical research applications, particularly in fatty acid metabolism studies and tracer experiments. Its unique labeling offers advantages in quantification and tracking of biological processes involving unsaturated fatty acids.

(S)-N-Methylpyrrolidine-2-methanol-d5 is a stable isotope-labeled version of (S)-N-Methylpyrrolidine-2-methanol, functioning as a biochemical reagent in life science research. This compound serves as a valuable tool for studying biological processes and interactions in various experimental settings. Its deuterium labeling enhances tracking capabilities and provides insights into molecular dynamics and mechanisms.

Borocaptate-10B12 sodium is a stable isotope-labeled boron-containing compound designed for use in boron neutron capture therapy (BNCT). It serves as an effective therapeutic agent, demonstrating notable anticancer activity through the selective delivery of boron-10 to tumor cells. Its application in research facilitates the exploration of BNCT's potential in cancer treatment, enhancing the understanding of targeted therapies.

1H-Pyrazole-3,4,5-d3 is a deuterated form of 1H-pyrazole, a nitrogen-containing heterocyclic compound characterized by a five-membered ring containing two nitrogen atoms. This stable isotope serves as a valuable intermediate in organic synthesis and exhibits the ability to coordinate with metal ions. Moreover, derivatives of 1H-pyrazole have been identified with significant antibacterial, anti-inflammatory, anti-malarial, and anti-leishmanial activities, making this compound useful in various research applications.

4-Amino-TEMPO-d17 (4-Amino-2,2,6,6-tetramethylpiperidine-1-oxyl-d17) is a deuterium-labeled derivative of the stable nitroxide radical 4-Amino-TEMPO. This compound exhibits superoxide dismutase-mimetic activity, providing cellular protection against oxidative stress and radioprotective effects. It is utilized in diverse research applications, including biomedicine for antioxidant studies, materials science for stabilization of polymers, and as a spin label for detecting free radicals in oxidative research.

Iopamidol-d3 is the deuterated variant of the nonionic, X-ray iodinated contrast agent Iopamidol. This stable isotope is utilized in various diagnostic applications, particularly in imaging techniques. Its amide and hydroxyl groups enable the exploration of chemical exchange saturation transfer (CEST) contrast, making it a valuable tool in scientific research and clinical imaging studies.

BOC-L-phenylalanine-d8 is a deuterated form of BOC-L-phenylalanine, serving as a stable isotope in chemical research. This compound plays a critical role in the synthesis of various bioactive molecules and acts as a capping agent in peptide synthesis. Its unique isotopic labeling enables precise studies in metabolic pathways and protein dynamics, making it a valuable tool for researchers in biochemistry and molecular biology.

Tetrabutylammonium-d36 iodide is a deuterium-labeled derivative of tetrabutylammonium iodide, functioning primarily as a stable isotope. It serves as a phase transfer catalyst and surfactant, enhancing the efficiency of ion or molecule transfer in organic synthesis and various chemical reactions. Its unique properties make it a valuable reagent in both industrial applications and chemical research, allowing for improved reaction rates and yields.

Sulfobetaine-12-d25 is a deuterium-labeled variant of Sulfobetaine-12, functioning as a zwitterionic surfactant with both positive and negative charges. This compound exhibits key biological activities as a mild detergent, promoting emulsion stabilization and offering non-irritating properties suitable for pharmaceutical, cosmetic, and personal care applications. Additionally, its antistatic characteristics make it effective for cleaning electronics and other surfaces prone to static charge.

24 Bisphenol S-13C12 is a 13C-labeled derivative of 2,4'-Dihydroxydiphenyl sulfone, serving as a stable isotope for analytical applications. This compound exhibits biological activity as an active small molecule and is utilized in the development of fire-resistant polyester compositions. Its isotopic labeling facilitates tracking and quantification in various chemical research studies.

Tryptamine-d2-1 hydrochloride is a deuterium-labeled form of tryptamine, an indole alkaloid derivative of the amino acid tryptophan. This compound serves as a stable isotope and is primarily utilized in research applications aimed at studying neurological pathways and psychoactive properties. Its unique labeling allows for precise tracking in metabolic studies and the synthesis of related organic compounds. Tryptamine-d2-1 hydrochloride provides valuable insights into neurotransmitter functions, with implications for mood, perception, and cognition research.

(R,S)-Anatabine-d4 is a deuterated form of (R,S)-Anatabine, a minor alkaloid derived from the Solanaceae family of plants. This stable isotope serves as a specific biomarker for the detection and quantification of tobacco use in biological samples. Its use in research applications facilitates the study of tobacco-related health effects and helps to understand nicotine consumption patterns.

1-Methylpiperidin-4-ol-d4 is a deuterated derivative of 1-Methylpiperidin-4-ol, serving as a stable isotope labeled compound. It is utilized in various biochemical research applications, particularly in studies involving metabolic pathways and compound tracking. This reagent aids in enhancing the accuracy of quantitative analyses and provides valuable insights in life sciences and pharmacokinetics.

4'-Bromoacetophenone-d7 is a deuterated form of 4'-Bromoacetophenone, serving as a stable isotope labeled compound. This reagent is primarily utilized in biological and organic chemistry research, enabling tracking and quantification of biological processes through stable isotope labeling techniques. Its applications extend to metabolic studies, synthesis of labeled compounds, and mass spectrometry analysis, providing valuable information in various life science research contexts.

Acid Orange 7-13C6 is a stable isotope-labeled variant of Acid Orange 7, an azo dye primarily utilized in textiles, food, and cosmetics. This compound forms azo bonds with various substrates, allowing for effective colorant applications. Acid Orange 7-13C6 exhibits a maximum absorption wavelength at 484-485 nm, suitable for quantification via UV-visible spectrophotometry. Its persistence and toxicity make it valuable in research focused on wastewater treatment technologies, photocatalytic degradation processes, and the assessment of different treatment methods on organic pollutant removal.

Cyclopropylmethyl bromide-d3 is a deuterated stable isotope of cyclopropylmethyl bromide, serving as a valuable intermediate in organic synthesis. This compound has applications in the preparation of Firocoxib, a potent and selective inhibitor of the cyclooxygenase-2 (COX-2) enzyme. Firocoxib is used extensively in research involving inflammatory pathways and pain management studies.

Leucomalachite green-d6 is a deuterated derivative of Leucomalachite green, serving as a stable isotope for research applications. This compound is known for its reduced cytotoxicity compared to malachite green and may interfere with cellular metabolism or redox balance. It is utilized in studies to assess the potential impacts of food contaminants on human cells, particularly in the context of cytotoxicity evaluation.

Cyclohexane-1,3-dione-13C3 is a stable isotope-labeled form of Cyclohexane-1,3-dione, providing a valuable tool for metabolic studies and tracer experiments. As a biochemical reagent, it is utilized in the investigation of metabolic pathways and compound tracking within biological systems. Its unique isotopic signature allows for enhanced detection and quantification in various research applications, contributing to advancements in organic chemistry and life sciences.

4-Amino-TEMPO-d17,15N is a stable isotope-labeled derivative of 4-Amino-TEMPO, serving as a nitroxide radical and N-nucleophile with applications in oxidative stress research. It exhibits superoxide dismutase-mimetic activity, providing cellular protection against oxidative damage and offering radioprotective effects. This compound is valuable in biomedicine, materials science, and industrial applications, functioning as a spin label for free radical detection, an oxidation catalyst, and an antioxidant stabilizer for polymers.

Glycidyl stearate-d5 is a deuterated form of glycidyl stearate, featuring reactive oxirane groups that enhance its unique chemical properties. As an ester derived from stearic acid and epichlorohydrin, it serves as a valuable stable isotope in chemical research. This compound is primarily utilized in studies involving coatings, adhesives, and surfactants, as well as in the synthesis of crosslinking agents for polymers and resins. Its deuterium labeling allows for precise tracking and analysis in various applications.

Cyclopropylmethyl bromide-d4 is a deuterium-labeled stable isotope of Cyclopropylmethyl bromide, serving as an important chemical intermediate in synthetic chemistry. It is utilized in the preparation of Firocoxib, a selective and potent COX-2 inhibitor employed in pharmacological research. This compound facilitates targeted studies investigating the mechanisms of COX-2 inhibition and its related therapeutic applications.

Methyl picolinate-d4 is a deuterated form of Methyl picolinate, serving as a stable isotope for chemical analysis. It is utilized in various life science research applications, particularly in metabolomics and tracer studies. Its stable isotopic labeling facilitates the precise quantification and tracking of biochemical pathways, making it an essential reagent for researchers investigating metabolic processes.