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Istradefylline (KW-6002)

Catalog No.: A11451

A2A antagonist

Istradefylline (KW-6002)

Istradefylline (KW-6002) Chemical Structure

CAS NO. 155270-99-8

Istradefylline (KW-6002) is a selective antagonist at the A2A receptor. It has been found to be useful in the treatment of Parkinson's disease.

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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • PU Hamor, .et al. The Role of Glutamate mGlu5 and Adenosine A2a Receptor Interactions in Regulating Working Memory Performance and Persistent Cocaine Seeking in Rats, Prog Neuropsychopharmacol Biol Psychiatry, 2020, Dec 20;103:109979 PMID: 32470496

Biological Activity

Istradefylline (KW-6002) is a selective antagonist at the A2A receptor. It has been found to be useful in the treatment of Parkinson's disease.
Adenosine A2A receptor
2.2 nM(Ki)
In vitro (25°C) DMSO 5 mg/mL (13 mM)
Water Insoluble
Ethanol Insoluble
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.01 mL 130.07 mL 260.15 mL
0.5 mM 5.2 mL 26.01 mL 52.03 mL
1 mM 2.6 mL 13.01 mL 26.01 mL
5 mM 0.52 mL 2.6 mL 5.2 mL

*The above data is based on the productmolecular weight 384.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11451
Actions Antagonist
CAS No. 155270-99-8
Formula C20H24N4O4
M. Wt 384.4
Purity >98%
Synonyms KW-6002,KW6002

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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