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Biological Activity
Ixazomib citrate (MLN9708) is a reversible inhibitor of the chymotrypsin-like proteolytic β5 site of the 20S proteasome with an IC50 of 3.4 nM and a Ki of 0.93 nM.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.34 mL | 96.69 mL | 193.38 mL |
| 0.5 mM | 3.87 mL | 19.34 mL | 38.68 mL |
| 1 mM | 1.93 mL | 9.67 mL | 19.34 mL |
| 5 mM | 0.39 mL | 1.93 mL | 3.87 mL |
*The above data is based on the productmolecular weight 517.12. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A18017 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1239908-20-3 |
| Formula | C20H23BCl2N2O9 |
| M. Wt | 517.12 |
| Purity | >98% |
| Synonyms | MLN9708 citrate, MLN 9708, MLN-9708 |
| SMILES | O=C(O)CC1(CC(O)=O)OB([C@@H](NC(CNC(C2=CC(Cl)=CC=C2Cl)=O)=O)CC(C)C)OC1=O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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