Fig. 1 · Structure
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J-113397
ORL1 Receptor Antagonist
J-113397 is a potent and selective nonpeptidyl antagonist of the ORL1 receptor, exhibiting a binding affinity with a Ki of 1.8 nM for cloned human ORL1. This compound is notable for its lack of agonistic activity on other opioid receptors, making it a valuable tool for studying the physiological and pharmacological roles of the ORL1 receptor. J-113397 is applicable in research focused on pain modulation, addiction, and various neurodegenerative diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 256640-45-6 |
| Applications | ORL1 Receptor Antagonist |
| Formula | C24H37N3O2 |
| Molecular Weight | 399.57 |
| SMILES | O=C1N([C@H]2[C@@H](CN(CC2)CC3CCCCCCC3)CO)C4=CC=CC=C4N1CC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.