J-113397 is a potent and selective nonpeptidyl antagonist of the ORL1 receptor, exhibiting a binding affinity with a Ki of 1.8 nM for cloned human ORL1. This compound is notable for its lack of agonistic activity on other opioid receptors, making it a valuable tool for studying the physiological and pharmacological roles of the ORL1 receptor. J-113397 is applicable in research focused on pain modulation, addiction, and various neurodegenerative diseases.
J-113397 is a potent and selective nonpeptidyl antagonist of the ORL1 receptor, exhibiting a binding affinity with a Ki of 1.8 nM for cloned human ORL1. This compound is notable for its lack of agonistic activity on other opioid receptors, making it a valuable tool for studying the physiological and pharmacological roles of the ORL1 receptor. J-113397 is applicable in research focused on pain modulation, addiction, and various neurodegenerative diseases.
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