J30-8 is a potent and isoform-selective inhibitor of c-Jun N-terminal kinase 3 (JNK3), exhibiting an IC50 value of 40 nM and a remarkable 2500-fold selectivity over JNK1α1 and JNK2α2 isoforms. This compound demonstrates significant neuroprotective activity in vitro, making it a valuable tool for researching neurodegenerative diseases and their therapeutic interventions.
J30-8 is a potent and isoform-selective inhibitor of c-Jun N-terminal kinase 3 (JNK3), exhibiting an IC50 value of 40 nM and a remarkable 2500-fold selectivity over JNK1α1 and JNK2α2 isoforms. This compound demonstrates significant neuroprotective activity in vitro, making it a valuable tool for researching neurodegenerative diseases and their therapeutic interventions.
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