JAK-IN-20 is a potent, pan-selective Janus kinase (JAK) inhibitor, exhibiting IC50 values of 7 nM, 5 nM, and 14 nM for JAK1, JAK2, and JAK3, respectively. This orally active compound demonstrates favorable pharmacokinetic properties and exerts significant anti-inflammatory effects in vivo. JAK-IN-20 is suitable for research applications targeting JAK signaling pathways, particularly in the contexts of autoimmune diseases and chronic inflammation.
JAK-IN-20 is a potent, pan-selective Janus kinase (JAK) inhibitor, exhibiting IC50 values of 7 nM, 5 nM, and 14 nM for JAK1, JAK2, and JAK3, respectively. This orally active compound demonstrates favorable pharmacokinetic properties and exerts significant anti-inflammatory effects in vivo. JAK-IN-20 is suitable for research applications targeting JAK signaling pathways, particularly in the contexts of autoimmune diseases and chronic inflammation.
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