JAK-IN-26 is an orally active Janus kinase (JAK) inhibitor that effectively targets the JAK-STAT signaling pathway. It demonstrates significant inhibitory activity on IFN-α2B-induced phosphorylation of STAT3 in Jurkat cells, with an IC50 value of 17.2 nM. This compound is valuable for research applications focused on cytokine signaling, immune response modulation, and the study of JAK-related signaling pathways in various disease contexts.
JAK-IN-26 is an orally active Janus kinase (JAK) inhibitor that effectively targets the JAK-STAT signaling pathway. It demonstrates significant inhibitory activity on IFN-α2B-induced phosphorylation of STAT3 in Jurkat cells, with an IC50 value of 17.2 nM. This compound is valuable for research applications focused on cytokine signaling, immune response modulation, and the study of JAK-related signaling pathways in various disease contexts.
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