JAK2-IN-18 is a selective JAK2 inhibitor that disrupts JAK-STAT signaling pathways with an IC50 of less than 100 nM for pSTAT5 in HEL9217 cells. This reagent effectively inhibits the proliferation of aberrantly proliferating myeloid cells, making it a valuable tool for studying myeloproliferative disorders, such as essential thrombocythemia. Its specificity and potency facilitate research aimed at understanding the molecular mechanisms underlying these conditions.
JAK2-IN-18 is a selective JAK2 inhibitor that disrupts JAK-STAT signaling pathways with an IC50 of less than 100 nM for pSTAT5 in HEL9217 cells. This reagent effectively inhibits the proliferation of aberrantly proliferating myeloid cells, making it a valuable tool for studying myeloproliferative disorders, such as essential thrombocythemia. Its specificity and potency facilitate research aimed at understanding the molecular mechanisms underlying these conditions.
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