JAK3-IN-11 is a potent, irreversible inhibitor of Janus kinase 3 (JAK3) with an IC50 value of 1.7 nM, demonstrating exceptional selectivity with over 588-fold distinction from other JAK isoforms. This orally active compound covalently binds to the ATP-binding pocket of JAK3, effectively attenuating JAK3-dependent signaling pathways and T cell proliferation. JAK3-IN-11 is a valuable reagent for investigating autoimmune diseases and related immunological research.
JAK3-IN-11 is a potent, irreversible inhibitor of Janus kinase 3 (JAK3) with an IC50 value of 1.7 nM, demonstrating exceptional selectivity with over 588-fold distinction from other JAK isoforms. This orally active compound covalently binds to the ATP-binding pocket of JAK3, effectively attenuating JAK3-dependent signaling pathways and T cell proliferation. JAK3-IN-11 is a valuable reagent for investigating autoimmune diseases and related immunological research.
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