JAK3-IN-12 is a potent inhibitor of Janus kinase 3 (JAK3), exhibiting IC50 values of 9.5 nM, 18 nM, and 42 nM for JAK3, JAK1, and JAK2, respectively. This compound serves as a valuable tool for investigating the role of JAK3 in various biological processes, particularly in the context of autoimmune diseases such as rheumatoid arthritis. Its selective inhibition can facilitate understanding of JAK3's function and its potential as a therapeutic target in related research applications.
JAK3-IN-12 is a potent inhibitor of Janus kinase 3 (JAK3), exhibiting IC50 values of 9.5 nM, 18 nM, and 42 nM for JAK3, JAK1, and JAK2, respectively. This compound serves as a valuable tool for investigating the role of JAK3 in various biological processes, particularly in the context of autoimmune diseases such as rheumatoid arthritis. Its selective inhibition can facilitate understanding of JAK3's function and its potential as a therapeutic target in related research applications.
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