JAK3-IN-14 is a selective JAK3 inhibitor that demonstrates potent activity with an IC50 of 38 nM for JAK3 and 600 nM for JAK2. This compound effectively inhibits IL-4 and IL-3 induced proliferation of TF-1 cells, exhibiting IC50 values of 600 nM and 500 nM, respectively. JAK3-IN-14 is valuable for research applications related to cytokine signaling and immune response modulation.
JAK3-IN-14 is a selective JAK3 inhibitor that demonstrates potent activity with an IC50 of 38 nM for JAK3 and 600 nM for JAK2. This compound effectively inhibits IL-4 and IL-3 induced proliferation of TF-1 cells, exhibiting IC50 values of 600 nM and 500 nM, respectively. JAK3-IN-14 is valuable for research applications related to cytokine signaling and immune response modulation.
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