JH-131e-153 is a diacylglycerol (DAG)-lactone that functions as a small molecule activator of Munc13-1 by targeting its C1 domain. This compound demonstrates a specific activation sequence for Munc13-1, with a comparative hierarchy of WT>I590≈R592A≈W588A. Its activation profile reveals homology with protein kinase C (PKC), indicating potential cross-functional mechanisms. JH-131e-153 plays a crucial role in modulating neuronal processes and serves as a valuable tool for investigating the underlying mechanisms of neurodegenerative diseases.
JH-131e-153 is a diacylglycerol (DAG)-lactone that functions as a small molecule activator of Munc13-1 by targeting its C1 domain. This compound demonstrates a specific activation sequence for Munc13-1, with a comparative hierarchy of WT>I590≈R592A≈W588A. Its activation profile reveals homology with protein kinase C (PKC), indicating potential cross-functional mechanisms. JH-131e-153 plays a crucial role in modulating neuronal processes and serves as a valuable tool for investigating the underlying mechanisms of neurodegenerative diseases.
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