Jingzhaotoxin-III is a highly selective blocker of Nav1.5 sodium channels, exhibiting an IC50 of 348 nM with no significant impact on other sodium channel isoforms. This toxin selectively inhibits the activation of cardiac sodium channels, making it a valuable tool for research focused on cardiac physiology and pathophysiology. Its specificity for the cardiac VGSC subtype positions Jingzhaotoxin-III as an important ligand for studies related to cardiovascular health and disease.
Jingzhaotoxin-III is a highly selective blocker of Nav1.5 sodium channels, exhibiting an IC50 of 348 nM with no significant impact on other sodium channel isoforms. This toxin selectively inhibits the activation of cardiac sodium channels, making it a valuable tool for research focused on cardiac physiology and pathophysiology. Its specificity for the cardiac VGSC subtype positions Jingzhaotoxin-III as an important ligand for studies related to cardiovascular health and disease.
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