(-)-JM-1232 is a ligand for GABA A receptors that binds to the benzodiazepine binding site, leading to pronounced analgesic effects. This compound has shown significant efficacy in preclinical models, with CI50 values of 2.96 mg/kg for acute thermal stimuli, 3.06 mg/kg for mechanically induced pain, and 2.27 mg/kg for visceral pain. The potent analgesic properties of (-)-JM-1232 make it a valuable tool for research focused on pain mechanisms and the development of analgesic therapies.
(-)-JM-1232 is a ligand for GABA A receptors that binds to the benzodiazepine binding site, leading to pronounced analgesic effects. This compound has shown significant efficacy in preclinical models, with CI50 values of 2.96 mg/kg for acute thermal stimuli, 3.06 mg/kg for mechanically induced pain, and 2.27 mg/kg for visceral pain. The potent analgesic properties of (-)-JM-1232 make it a valuable tool for research focused on pain mechanisms and the development of analgesic therapies.
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