JNJ-42253432 is a high-affinity orally active antagonist of the P2X7 receptor, exhibiting significant CNS penetration. With pKi values of 9.1 for rat and 7.9 for human P2X7 channels, it effectively modulates purinergic signaling. This compound is valuable for research on neuroinflammation, pain pathways, and other P2X7-related biological processes.
JNJ-42253432 is a high-affinity orally active antagonist of the P2X7 receptor, exhibiting significant CNS penetration. With pKi values of 9.1 for rat and 7.9 for human P2X7 channels, it effectively modulates purinergic signaling. This compound is valuable for research on neuroinflammation, pain pathways, and other P2X7-related biological processes.
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