JNJ-42259152

Catalog No.: A41987
Phosphodiesterase (PDE)
JNJ-42259152 is a selective phosphodiesterase 10A (PDE10A) positron emission tomography (PET) tracer designed to assess PDE10A activity in vivo. This compound demonstrates reliable binding potential across critical brain regions, including the lentiform nucleus, caudate nucleus, and ventral striatum, making it a valuable tool in the exploration of neuropsychiatric disorders. With an average blood half-life of 90 minutes, JNJ-42259152 enables detailed kinetic analysis in healthy subjects, supporting research into the underlying mechanisms of various central nervous system conditions.
Grouped product items
Size Price Stock Qty
25mg
$1,275.00
In stock
50mg
$1,625.00
In stock
100mg
$2,000.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionJNJ-42259152 is a selective phosphodiesterase 10A (PDE10A) positron emission tomography (PET) tracer designed to assess PDE10A activity in vivo. This compound demonstrates reliable binding potential across critical brain regions, including the lentiform nucleus, caudate nucleus, and ventral striatum, making it a valuable tool in the exploration of neuropsychiatric disorders. With an average blood half-life of 90 minutes, JNJ-42259152 enables detailed kinetic analysis in healthy subjects, supporting research into the underlying mechanisms of various central nervous system conditions.
Product Information
Catalog NumA41987
FormulaC24H23FN4O
Molecular Weight402.46
CAS Number1301167-87-2
SMILESCC1=CN=C(C(C)=C1)COC2=CC=C(C=C2)C3=NN(C=C3C4=CC=NC=C4)CCF
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