(+)-JNJ-A07 is a highly potent, orally active pan-serotype dengue virus inhibitor that targets the NS3–NS4B protein interaction. It demonstrates nanomolar to picomolar antiviral activity across a panel of 21 clinical dengue virus isolates. With a favorable pharmacokinetic profile, (+)-JNJ-A07 exhibits exceptional efficacy in mouse models of dengue virus infection, making it a strong candidate for antiviral research and therapeutic development.
(+)-JNJ-A07 is a highly potent, orally active pan-serotype dengue virus inhibitor that targets the NS3–NS4B protein interaction. It demonstrates nanomolar to picomolar antiviral activity across a panel of 21 clinical dengue virus isolates. With a favorable pharmacokinetic profile, (+)-JNJ-A07 exhibits exceptional efficacy in mouse models of dengue virus infection, making it a strong candidate for antiviral research and therapeutic development.
Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
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