JNK-1-IN-3 is a selective inhibitor of JNK1 that effectively downregulates JNK1 gene expression and decreases the levels of its phosphorylated form. This compound concurrently reduces the expression of key downstream targets, including c-Jun and c-Fos, while enhancing p53 activity. JNK-1-IN-3 demonstrates significant antiproliferative effects, especially against renal and breast cancer cell lines, showcasing both in vitro and in vivo anticancer activity, making it a valuable tool for cancer research and therapeutic investigations.
JNK-1-IN-3 is a selective inhibitor of JNK1 that effectively downregulates JNK1 gene expression and decreases the levels of its phosphorylated form. This compound concurrently reduces the expression of key downstream targets, including c-Jun and c-Fos, while enhancing p53 activity. JNK-1-IN-3 demonstrates significant antiproliferative effects, especially against renal and breast cancer cell lines, showcasing both in vitro and in vivo anticancer activity, making it a valuable tool for cancer research and therapeutic investigations.
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