JNK-IN-23 is a potent inhibitor of c-Jun N-terminal kinases (JNK), demonstrating significant antiproliferative activity against MDA-MB-231 cells with a GIC50 of 30 nM. It effectively impedes metastatic growth in triple-negative breast cancer (TNBC) models in vivo, significantly reducing lung metastasis rates. JNK-IN-23 functions through the dual targeting of glutaminase-1 (GLS) and pyruvate dehydrogenase complex (PDHC), making it a valuable tool for research into cancer metabolism and metastasis.
JNK-IN-23 is a potent inhibitor of c-Jun N-terminal kinases (JNK), demonstrating significant antiproliferative activity against MDA-MB-231 cells with a GIC50 of 30 nM. It effectively impedes metastatic growth in triple-negative breast cancer (TNBC) models in vivo, significantly reducing lung metastasis rates. JNK-IN-23 functions through the dual targeting of glutaminase-1 (GLS) and pyruvate dehydrogenase complex (PDHC), making it a valuable tool for research into cancer metabolism and metastasis.
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