JNK-IN-25 is a highly selective inhibitor of JNK1, JNK2, and JNK3, exhibiting IC50 values of 1.54 nM, 1.99 nM, and 0.75 nM, respectively. This compound acts by covalently binding to the conserved cysteine residue in the JNK isoforms, thereby obstructing the phosphorylation of c-Jun. JNK-IN-25 is valuable for investigating pathways involved in cancer, as well as in inflammatory and neurodegenerative diseases.
JNK-IN-25 is a highly selective inhibitor of JNK1, JNK2, and JNK3, exhibiting IC50 values of 1.54 nM, 1.99 nM, and 0.75 nM, respectively. This compound acts by covalently binding to the conserved cysteine residue in the JNK isoforms, thereby obstructing the phosphorylation of c-Jun. JNK-IN-25 is valuable for investigating pathways involved in cancer, as well as in inflammatory and neurodegenerative diseases.
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