JNK3-IN-10 is a selective inhibitor of JNK3, demonstrating an IC50 value of 0.257 nM and exhibiting over 400-fold selectivity over JNK1. This compound effectively disrupts the JNK3-mediated signaling pathway in response to TGF-β1, leading to the inhibition of c-Jun phosphorylation and a reduction in pro-fibrotic marker expression while restoring E-cadherin levels. Its low cytotoxicity profile, along with anti-fibrotic, cytoprotective, and renoprotective properties, makes JNK3-IN-10 a valuable tool for investigating chronic kidney disease, glomerulosclerosis, and adriamycin-induced nephropathy.
JNK3-IN-10 is a selective inhibitor of JNK3, demonstrating an IC50 value of 0.257 nM and exhibiting over 400-fold selectivity over JNK1. This compound effectively disrupts the JNK3-mediated signaling pathway in response to TGF-β1, leading to the inhibition of c-Jun phosphorylation and a reduction in pro-fibrotic marker expression while restoring E-cadherin levels. Its low cytotoxicity profile, along with anti-fibrotic, cytoprotective, and renoprotective properties, makes JNK3-IN-10 a valuable tool for investigating chronic kidney disease, glomerulosclerosis, and adriamycin-induced nephropathy.
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