JNK3 inhibitor-4 is a selective inhibitor targeting JNK3 (IC50 = 1.0 nM), derived from a 2-aryl-1-pyrimidinyl-1H-imidazole-5-yl acetonitrile scaffold. It demonstrates remarkable selectivity over JNK1 (IC50 = 143.9 nM) and JNK2 (IC50 = 298.2 nM). This compound exhibits neuroprotective properties and shows potential for effective delivery across the blood-brain barrier, making it valuable for research in neurodegenerative diseases and other neurological disorders.
JNK3 inhibitor-4 is a selective inhibitor targeting JNK3 (IC50 = 1.0 nM), derived from a 2-aryl-1-pyrimidinyl-1H-imidazole-5-yl acetonitrile scaffold. It demonstrates remarkable selectivity over JNK1 (IC50 = 143.9 nM) and JNK2 (IC50 = 298.2 nM). This compound exhibits neuroprotective properties and shows potential for effective delivery across the blood-brain barrier, making it valuable for research in neurodegenerative diseases and other neurological disorders.
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