JP-163-16 is a RelA/p65 PROTAC degrader that facilitates the selective degradation of RelA/p65 via the proteasome pathway. By inhibiting the NF-κB signaling pathway, JP-163-16 promotes apoptosis in cells, making it a valuable tool for investigating RelA/p65-dependent tumors, including chronic lymphocytic leukemia (CLL). This compound is instrumental for studies aimed at understanding the role of NF-κB in cancer progression and therapeutic resistance.
JP-163-16 is a RelA/p65 PROTAC degrader that facilitates the selective degradation of RelA/p65 via the proteasome pathway. By inhibiting the NF-κB signaling pathway, JP-163-16 promotes apoptosis in cells, making it a valuable tool for investigating RelA/p65-dependent tumors, including chronic lymphocytic leukemia (CLL). This compound is instrumental for studies aimed at understanding the role of NF-κB in cancer progression and therapeutic resistance.
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