JW74

Catalog No.: A16219

Wnt inhibitor

JW74

JW74 Chemical Structure

CAS NO. 863405-60-1

JW74 is an efficient and specific inhibitor of the canonical Wnt signaling. JW74 shows a reduction of canonical Wnt signaling in the ST-Luc assay with IC50 values of 790 nM.

Availability: In stock

Package Price Qty
5 mg
$70.00
10 mg
$100.00
50 mg
$350.00
Custom Size Get quote

Free Overnight Delivery on orders over $500

Next day delivery by 10:00 a.m. Order now.

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Yang JM, .et al. LGK974, a PORCUPINE inhibitor, mitigates cytotoxicity in an in vitro model of Parkinson's disease by interfering with the WNT/β-CATENIN pathway, Toxicology, 2018, Dec 1;410:65-72 PMID: 30205152

Biological Activity

JW74 is an efficient and specific inhibitor of the canonical Wnt signaling. JW74 shows a reduction of canonical Wnt signaling in the ST-Luc assay with IC50 values of 790 nM.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.9 mL 109.52 mL 219.05 mL
0.5 mM 4.38 mL 21.9 mL 43.81 mL
1 mM 2.19 mL 10.95 mL 21.9 mL
5 mM 0.44 mL 2.19 mL 4.38 mL

*The above data is based on the productmolecular weight 456.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A16219
Actions Inhibitor
CAS No. 863405-60-1
Formula C24H20N6O2S
M. Wt 456.52
Purity >98%
Synonyms JW-74, JW 74
SMILES CC1=CC=C(C2=NOC(CSC3=NN=C(C4=CC=NC=C4)N3C5=CC=C(OC)C=C5)=N2)C=C1
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Tags

Product Tags

Use spaces to separate tags. Use single quotes (') for phrases.

Product Questions

Product Questions

No Questions
Keywords:buy JW74 | JW74 Supplier | purchase | cost | manufacturer | order | distributor | buy 863405-60-1| 863405-60-1 Supplier | purchase 863405-60-1 | 863405-60-1 cost | 863405-60-1 manufacturer | order 863405-60-1 | 863405-60-1 distributor
Rewards