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- Yang JM, .et al. LGK974, a PORCUPINE inhibitor, mitigates cytotoxicity in an in vitro model of Parkinson's disease by interfering with the WNT/β-CATENIN pathway, Toxicology, 2018, Dec 1;410:65-72 PMID: 30205152
|Storage||at -20°C 3 years Powder|
|Synonyms||JW-74, JW 74|
|JW74 is an efficient and specific inhibitor of the canonical Wnt signaling. JW74 shows a reduction of canonical Wnt signaling in the ST-Luc assay with IC50 values of 790 nM.|
Preparing Stock Solutions
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||21.9 mL||109.52 mL||219.05mL|
|0.5 mM||4.38 mL||21.9 mL||43.81 mL|
|1 mM||2.19 mL||10.95 mL||21.9 mL|
|5 mM||0.44 mL||2.19 mL||4.38 mL|
*The above data is based on the productmolecular weight 456.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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