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JW74

Wnt inhibitor

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Catalog No. A16219

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
JW74 5mg A16219-5
$70.00
JW74 10mg A16219-10
$100.00
JW74 50mg A16219-50
$350.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

JW74 is an efficient and specific inhibitor of the canonical Wnt signaling. JW74 shows a reduction of canonical Wnt signaling in the ST-Luc assay with IC50 values of 790 nM.

JW74

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Publications citing Adooq Products
JW74 Citations (1)
  • Yang JM, .et al. LGK974, a PORCUPINE inhibitor, mitigates cytotoxicity in an in vitro model of Parkinson's disease by interfering with the WNT/β-CATENIN pathway, Toxicology, 2018, Dec 1;410:65-72 PMID: 30205152

Chemical Information

Catalog Num A16219
Actions Inhibitor
M. Wt 456.52
Formula C24H20N6O2S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 863405-60-1
Synonyms JW-74, JW 74
SMILES CC1=CC=C(C2=NOC(CSC3=NN=C(C4=CC=NC=C4)N3C5=CC=C(OC)C=C5)=N2)C=C1

Biological Activity

Description
JW74 is an efficient and specific inhibitor of the canonical Wnt signaling. JW74 shows a reduction of canonical Wnt signaling in the ST-Luc assay with IC50 values of 790 nM.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.9 mL 109.52 mL 219.05mL
0.5 mM 4.38 mL 21.9 mL 43.81 mL
1 mM 2.19 mL 10.95 mL 21.9 mL
5 mM 0.44 mL 2.19 mL 4.38 mL

*The above data is based on the productmolecular weight 456.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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