Biological Activity
JX 401 is a potent, reversible inhibitor of the p38α isoform of MAP kinase (IC50 = 32 nM).
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 28.13 mL | 140.65 mL | 281.3 mL |
0.5 mM | 5.63 mL | 28.13 mL | 56.26 mL |
1 mM | 2.81 mL | 14.07 mL | 28.13 mL |
5 mM | 0.56 mL | 2.81 mL | 5.63 mL |
*The above data is based on the productmolecular weight 355.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A16038 |
---|---|
Actions | Inhibitor |
CAS No. | 349087-34-9 |
Formula | C21H25NO2S |
M. Wt | 355.49 |
Purity | >98% |
Synonyms | JX401, JX-401 |
SMILES | O=C(C(C(OC)=C1)=CC=C1SC)N2CCC(CC3=CC=CC=C3)CC2 |
Storage | Store lyophilized at -20ºC, keep desiccated. |
Product Tags
Product Questions
Product Questions
No Questions
You may also be interested in the following product(s)
SB 203580
SB 203580 is a specific inhibitor of p38α and p38β which suppresses downstream activation of MAPKAP kinase-2 and heat shock protein 27.
SB-242235
SB-242235 is a potent and selective p38 MAP kinase inhibitor that may be an effective therapy for cytokine-mediated diseases such as autoimm…
Asiatic acid
Asiatic acid is commonly used in wound healing. Asiatic acid has antioxidant, anti-inflammatory and neuroprotective properties. Asiatic acid…
SKF 86002 Dihydrochloride
SKF 86002 Dihydrochloride is inhibitor of p38 MAP kinase (IC50 = 0.1 - 1 uM). Potently inhibits LPS-induced IL-1 and TNF-α production in h…
Talmapimod (SCIO-469)
Talmapimod (SCIO-469) is a selective, ATP-competitive p38 inhibitor (IC50 = 9 nM for p38α in vitro).
DBM 1285 dihydrochloride
DBM 1285 dihydrochloride is a p38 MAPK inhibitor. Supresses p38 phosphorylation and LPS-induced TNF-α production in macrophages and in viv…
VX-745
VX-745 is a small-molecule inhibitor of MAPK that is reported to be active against several isotypes of p38 MAPK, including p38α, p38βand p…
Pexmetinib (ARRY-614)
Pexmetinib is a potent inhibitor of cytokine synthesis, via the dual inhibition of p38 mitogen-activated protein kinase (MAPK), and Tie2/Tek…
Keywords:buy JX 401 | JX 401 Supplier | purchase | cost | manufacturer | order | distributor | buy 349087-34-9| 349087-34-9 Supplier | purchase 349087-34-9 | 349087-34-9 cost | 349087-34-9 manufacturer | order 349087-34-9 | 349087-34-9 distributor