JZ-4109 is a potent β-Glucocerebrosidase (GCase) modulator, exhibiting an IC50 of 8 nM against wild-type recombinant GCase. This compound binds to an allosteric site at the GCase dimer interface, promoting dimerization and stabilizing both wild-type and GCase N370S mutant variants. JZ-4109 enhances GCase protein abundance, making it a valuable tool for research into Parkinson's disease and related conditions.
JZ-4109 is a potent β-Glucocerebrosidase (GCase) modulator, exhibiting an IC50 of 8 nM against wild-type recombinant GCase. This compound binds to an allosteric site at the GCase dimer interface, promoting dimerization and stabilizing both wild-type and GCase N370S mutant variants. JZ-4109 enhances GCase protein abundance, making it a valuable tool for research into Parkinson's disease and related conditions.
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