Catalog No.
Product Name
Application
Product Information
Citations
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α-mannosidases inhibitor
Kifunensine is a potent and selective inhibitor of class I α-mannosidases, originally isolated from *Actinomycete* species. It blocks the trimming of mannose residues from N-linked glycoproteins by inhibiting α-mannosidase I activity, thereby preventing proper glycoprotein maturation. Through this mechanism, Kifunensine disrupts endoplasmic reticulum–associated degradation (ERAD) pathways, leading to the accumulation of misfolded glycoproteins. It is widely used as a biochemical tool in studies of protein folding, quality control, and glycosylation. -
CHI3L1 Inhibitor
CHI3L1-IN-1 is a selective inhibitor of Chitinase-3-like protein 1 (CHI3L1), also known as YKL-40, with an IC50 of 50 nM. This compound exhibits additional effects by inhibiting the hERG channel with an IC50 of 2.3 μM. CHI3L1-IN-1 is valuable for research applications focused on the roles of CHI3L1 in inflammation and cancer, offering insights into its potential as a biomarker and therapeutic target. -
UDP-GalNAc Analog
UDP-GalNAz disodium is an analogue of UDP-GalNAc disodium, serving as a donor substrate for N-acetylgalactosaminyltransferases, which facilitate the transfer of GalNAc to various saccharide or peptide acceptors. This compound features an azide group, making it a valuable reagent for click chemistry applications. UDP-GalNAz disodium can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-bearing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions involving DBCO or BCN groups. It is useful in the study of glycosylation pathways and the synthesis of complex glycoproteins. -
Glycosidase
PNGase F is a glycosidase that facilitates the cleavage of internal glycosidic bonds within oligosaccharides. This enzyme effectively removes nearly all N-linked oligosaccharides from glycoproteins, making it a valuable tool in glycoanalytical workflows. Its capability to release N-glycans from glycoproteins enhances the analysis of protein glycosylation patterns in various research applications. -
β-Hexosaminidase Inhibitor
M-31850 is a selective and competitive inhibitor of β-hexosaminidase, demonstrating IC50 values of 6.0 μM for human HexA and 3.1 μM for human HexB. This compound also inhibits β-N-acetyl-D-hexosaminidase (OfHex2) with a Ki of 2.5 μM. M-31850 is valuable for research applications focused on lysosomal storage disorders and other biological contexts where β-hexosaminidase activity is implicated. -
GCase Substrate
PFB-FDGlu is a highly selective substrate for lysosomal Glucocerebrosidase (GCase), engineered to be metabolized into fluorescein upon GCase activity. This compound is cell permeable, facilitating its use in flow cytometry to measure GCase activity in living cells at the single-cell level. PFB-FDGlu serves as an essential tool for studying GCase function in various biological contexts and is particularly relevant in research related to lysosomal storage disorders. -
Sugar Donor
UDP-GlcNAz disodium is a sugar donor analogue of UDP-GlcNAc disodium, serving as a substrate for various N-acetylgalactosaminyltransferases that facilitate the transfer of GlcNAc to saccharide or peptide acceptors. In addition to its enzymatic applications, UDP-GlcNAz disodium is a valuable click chemistry reagent featuring an azide group, capable of participating in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. It also enables strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN-functionalized partners, making it useful for bioconjugation and labeling studies. -
Glycosidic Lyase
Heparitin sulfate lyase, also known as Heparinase III, is a glycosidic lyase that specifically targets heparan sulfate and heparin. This enzyme plays a crucial role in the degradation of glycosaminoglycans and is valuable for studies on low-molecular-weight heparin production. Additionally, Heparitin sulfate lyase is involved in cancer research, providing insights into tumor biology and therapeutic strategies. -
Bifidogenic Factor
Xylotriose is a natural xylooligosaccharide that serves as a bifidogenic factor, promoting the growth of beneficial bifidobacteria in the gastrointestinal tract. Its prebiotic properties enhance gut health by selectively stimulating the proliferation of these microorganisms. Xylotriose is utilized in research applications focused on gut microbiota modulation and may contribute to the development of functional foods aimed at improving digestive health. -
α-L-arabinofuranosidase Substrate
1,4-b-D-Xylopentaose is a linear pentasaccharide comprised of five β-D-xylose units linked by 1,4-glycosidic bonds. This compound functions as a specific substrate for the enzyme barley α-L-arabinofuranosidase, facilitating the study of enzyme activity and carbohydrate metabolism. It is widely utilized in research applications focused on plant cell wall degradation and glycoside hydrolases. -
α-L-fucosidase Inhibitor
Deoxyfuconojirimycin hydrochloride is a selective inhibitor of α-L-fucosidase, demonstrating a Ki value of 10 nM for human liver lysosomal α-L-fucosidase and 140 nM for Charonia lampas α-L-fucosidase. This compound effectively inhibits the activity of all soluble α-L-fucosidases present in human liver, including various post-translationally modified enzyme forms. Deoxyfuconojirimycin hydrochloride is primarily utilized in research focused on fucosidase-related enzyme activity and metabolic pathways, though it does not exhibit anti-HIV properties. -
Glycosidase
Heparinase II is a glycosidase that specifically targets heparin and heparan sulfate. It plays a crucial role in the structural and functional analysis of glycosaminoglycans, making it valuable in anticoagulant research and studies of tumor microenvironment modulation. Its enzymatic activity facilitates investigations into various biological processes, including cell signaling and the interaction of cancer cells with their surrounding matrix. -
GCase 2 Inhibitor
AMP-Deoxynojirimycin is a potent inhibitor of glucocerebrosidase 2 (GCase 2) and ceramide glucosyltransferase. This compound effectively interferes with glucosylceramide (GlcCer) biosynthesis, making it valuable for research related to lysosomal storage disorders and sphingolipid metabolism. Its biological activity positions AMP-Deoxynojirimycin as a significant tool for investigating the roles of GlcCer in various cellular processes and disease mechanisms. -
Glycosidase Substrate
4-Methylumbelliferyl α-L-arabinofuranoside serves as a substrate for glycosidase enzymes, facilitating the cleavage of α-L-arabinofuranosidic bonds. Upon hydrolysis, it generates the fluorescent product 4-methylumbelliferone, allowing for sensitive detection and quantification. This compound is valuable in enzyme activity assays, particularly in studies involving carbohydrate metabolism and glycoside hydrolase activity. -
Chromogenic Glycosidic Ligand
p-Nitrophenyl α-D-mannopyranoside is a chromogenic glycosidic ligand targeting glycosidase enzymes. This compound contains an α-D-mannopyranose moiety with a distinctive axial hydroxyl group at the C2 position, along with a p-nitrophenol portion that absorbs ultraviolet-visible light. p-Nitrophenyl α-D-mannopyranoside is essential for assessing glycosidase activity and exploring the sugar recognition properties of lectins, including Concanavalin A. -
Weed Inhibitor
Glucobrassicin potassium is a glucosinolate (GSL) that functions as a potent weed inhibitor. Isolated from wild carrot (Raphanus raphanistrum L.), it demonstrates significant potential in biological fumigation and allelopathy research. Its application in weed management studies supports the exploration of sustainable agricultural practices. -
GCase Ligand
GT-02216 is an allosteric ligand for Glucosylceramidase (GCase) that enhances its enzymatic activity. This compound not only promotes the activity of GCase in primary human fibroblasts in a dose-dependent manner but also effectively reduces the accumulation of hexosylsphingosine (HexCer), a substrate linked to various pathologies. Additionally, GT-02216 has demonstrated the ability to decrease Tau accumulation in mutant GBA1 fibroblasts, making it a valuable tool in the study of Parkinson’s disease and related neurodegenerative conditions. -
Glycosidic Hydrolase
α-Rhamnosidase is a glycosidic hydrolase that catalyzes the hydrolysis of α-rhamnosides, facilitating the enzymatic de-glycosylation of a variety of natural flavonoid glycosides. This enzyme plays a critical role in the metabolism of plant glycosides, contributing to the bioavailability of flavonoid compounds. It is widely used in research applications focusing on plant biochemistry, natural product studies, and the analysis of flavonoid bioactivity. -
GCase Inhibitor
Gcase Activator 2 is a pyrrolo[2,3-b]pyrazine that serves as a potent activator of β-glucocerebrosidase (GCase), with an EC50 of 3.8 μM. This compound facilitates GCase dimerization, promoting both K-type and V-type interactions. Gcase Activator 2 displays low metabolic clearance in both human and mouse systems, making it a valuable tool for research into GCase-related biological pathways and potential therapeutic applications in lysosomal storage disorders. -
CHI3L1 Inhibitor
CHI3L1-IN-3 is a potent inhibitor of CHI3L1, with dissociation constants of 13.76 μM and 13.5 μM as measured by MST and SPR assays, respectively. This compound exhibits favorable pharmacokinetic properties, including extended plasma half-lives and microsomal stability, alongside decreased intrinsic clearance. In biological assays, CHI3L1-IN-3 demonstrates dose-dependent cytotoxicity, effectively reduces spheroid mass, and inhibits cell migration in a three-dimensional multicellular glioblastoma (GBM) spheroid model. It serves as a valuable tool for investigating the roles of CHI3L1 in GBM research. -
Glycosidic Hydrolase
α-L-Arabinofuranosidase is a glycosidic hydrolase that specifically hydrolyzes the non-reducing termini of α-L-arabinofuranosyl residues found in polysaccharides such as arabinoxylan, arabinan, and arabinogalactan. This enzyme plays a crucial role in carbohydrate metabolism and is instrumental in the breakdown of complex carbohydrates. Its applications include enzymatic studies of plant-based polysaccharides and potential use in bioengineering for the modification of dietary fibers. -
Glucocerebrosidase Modulator
β-Glucocerebrosidase modulator 1 is a potent allosteric modulator targeting β-Glucocerebrosidase, with an EC50 of 9.0 μM and a Kd of 0.050 μM. This compound enhances the enzymatic activity of β-Glucocerebrosidase, making it a valuable tool for studying Gaucher disease and related lipid metabolism disorders. Its modulation of enzymatic function assists in elucidating biological pathways and may aid in the development of therapeutic interventions. -
Alkylresorcinol
5-Nonadecylresorcinol is an alkylresorcinol that functions as an inhibitor of β-hexosaminidase release in vitro. Its biological activity makes it a valuable tool for research investigating the role of β-hexosaminidase in various cellular processes. Applications include studies related to enzyme modulation and potential therapeutic interventions in conditions where β-hexosaminidase activity is implicated. -
Glucocerebrosidase Chaperone
NCGC00092410 is a selective glucocerebrosidase chaperone that enhances the enzyme's activity and lysosomal localization in mutant cell lines. With an IC50 of 31 nM, it demonstrates notable potency without affecting related hydrolases at concentrations up to 77 μM. This reagent is primarily utilized in research focused on Gaucher disease, providing insights into therapeutic strategies for this lysosomal storage disorder. -
CHI3L1:HSIII Inhibitor
CHI3L1-IN-2 is a selective inhibitor of CHI3L1 (Chitinase-3-Like Protein 1) that targets its interaction with heparan sulfate (CHI3L1:HSIII), exhibiting an IC50 of 26 nM. CHI3L1 is a glycoprotein linked to various pathological conditions including inflammation, fibrosis, and cancer. This compound serves as a valuable tool for researchers investigating the role of CHI3L1 in disease processes and therapeutic applications. -
GCase Activator
GCase Activator 3 is a glucocerebrosidase (GCase) activator that enhances enzyme stability and activity. This compound effectively reduces misfolding and degradation of mutant GCase proteins in fibroblasts and dopaminergic neurons, providing a potential therapeutic strategy for conditions such as Parkinson's disease and related synucleinopathies. GCase Activator 3 is instrumental in advancing research aimed at understanding and treating these neurodegenerative disorders. -
Fusion Protein
Berahyaluronidase alfa is a recombinant fusion protein that targets hyaluronidase PH-20 and associated proteins such as HYAL3 and SPAM1. This enzymatic agent facilitates the degradation of hyaluronic acid, thereby promoting increased tissue permeability. It is primarily utilized in the research of advanced and metastatic solid tumors, offering potential insights into tumor progression and therapeutic interventions. -
Glycosidase
Glyoxalase I (Glo-I) is a glycosidase that plays a crucial role in the detoxification of methylglyoxal (MOG). Its primary mechanism involves catalyzing the conversion of MOG to D-lactate, thereby mitigating cellular damage and reducing oxidative stress. This enzyme is significant in studies related to inflammation and cancer, making it an important target for research into therapeutic interventions aimed at these conditions. -
GCase Inhibitor
Glucocerebrosidase-IN-1 is a selective inhibitor of glucocerebrosidase (GCase), exhibiting an IC50 of 29.3 μM and a Ki of 18.5 μM. This compound is instrumental in research related to Gaucher disease and Parkinson's disease, allowing for the investigation of GCase's role in these conditions. Its potency and specificity make it a valuable tool for elucidating the biochemical pathways involved in lysosomal storage disorders. -
Exoglycosidase
α1-6 Mannosidase, Xanthomonas phaseoli is a highly specific exoglycosidase that hydrolyzes unbranched α1-6 linked mannose residues in oligosaccharides. This enzyme plays a crucial role in the structural modification of glycoproteins and polysaccharides, facilitating studies in glycan analysis, carbohydrate metabolism, and enzymatic reaction mechanisms. Its precise activity makes it an essential reagent for research in glycoscience and biochemistry. -
Substrate of β-lactosidase
p-Nitrophenyl β-D-lactoside acts as a substrate for β-lactosidase, facilitating the assessment of enzyme activity in various biological applications. This compound is also a substrate for cellobiohydrolase, making it valuable in studies involving carbohydrate metabolism. Its utility in glycobiology research underscores its importance for understanding glycan interactions and enzymatic functions. -
β-glucocerebrosidase Activator
N-Boc-3-hydroxy-1,2,3,6-tetrahydropyridine is a β-glucocerebrosidase activator that enhances enzyme activity by approximately 20%. This reagent is valuable for research into lysosomal storage disorders and related protein misfolding diseases, facilitating studies aimed at understanding and potentially treating these conditions. -
Sugar Donor
UDP-GlcNAz serves as an analog of UDP-GlcNAc, functioning primarily as a sugar donor substrate for N-acetylgalactosaminyltransferases. These enzymes utilize UDP-GlcNAz to transfer N-acetylglucosamine to saccharide or peptide acceptors. Featuring an azide group, UDP-GlcNAz is also a valuable click chemistry reagent, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne-containing molecules. Its versatility makes it suitable for various applications in chemical biology and glycobiology research. -
Glycoside
2-Methylbutyl β-D-glucopyranoside is a glycoside that functions as an aroma precursor in apple fruit. Upon enzymatic hydrolysis, it releases the volatile compound 2-methylbutanol, which contributes to the characteristic aroma profile of various food products. This reagent is useful in research focused on food flavor chemistry and the biochemical processes underlying flavor development in fruits. -
α-galactosidase A Inhibitor
Migalastat is an orally active inhibitor of α-galactosidase A, functioning primarily as a molecular chaperone with an IC50 value of 0.04 μM for human α-Gal A. This compound selectively binds to the active site of specific unstable mutant forms of α-galactosidase A, promoting their proper transport to the lysosome. Upon dissociating in the acidic lysosomal environment, Migalastat enhances the biological activity of the mutant enzyme, making it a valuable tool in research related to lysosomal storage disorders. -
Molecular Chaperone
N-Octyl-α-4-epivalienamine is a potent molecular chaperone that enhances the expression of deficient β-galactosidase activity. This compound has demonstrated the ability to alleviate symptoms and improve survival rates in mouse models of GM1-gangliosidosis. N-Octyl-α-4-epivalienamine is valuable for research involving neurogenetic diseases and the development of therapeutic strategies targeting lysosomal storage disorders. -
GAA Agonist
5-C-heptyl-DNJ is a potent GAA agonist, exhibiting a Ki of 0.0047 μM. This compound enhances GAA activity through chaperone effects, making it valuable for research focused on lysosomal storage disorders and related biological pathways. Its ability to modulate GAA provides insights into enzyme replacement therapies and potential treatments for diseases associated with GAA deficiency. -
Alpha-Mannosidase Modulator
OMJ-4 is a modulator of mutant alpha-mannosidase that enhances its catalytic function. This compound promotes structural changes in the enzyme, increasing both the compactness and flexibility of the active site, which facilitates substrate binding. By inducing greater substrate reactivity, OMJ-4 decreases the activation energy needed for the enzymatic reaction. This reagent is significant for research focused on alpha-mannosidosis and related metabolic disorders. -
Glycosidase Inhibitor
(3R,4R)-4-(Hydroxymethyl)pyrrolidin-3-ol functions as a glycosidase inhibitor. This compound demonstrates significant biological activity by modulating the activity of glycosidases, which are crucial in carbohydrate metabolism. It serves as an important intermediate for the synthesis of various biologically active molecules, making it valuable in chemical research and drug development applications. -
α-Glycosidase Inhibitor
Terrestrimine is a potent α-Glycosidase inhibitor, demonstrating an IC50 of 225.83 μM. This compound is significant in the study of metabolic disorders, as it can modulate carbohydrate metabolism and glycemic control. It serves as a valuable tool for researchers investigating the role of glycosidase enzymes in various metabolic conditions. -
Glycosidase Inhibitor
(-)-Adenophorine is a potent glycosidase inhibitor that specifically targets α-L-fucosidase, exhibiting an IC50 of 72 μM. This compound plays a crucial role in biochemical research by facilitating studies on glycoprotein metabolism and cellular signaling pathways. Its ability to modulate glycosidase activity makes it a valuable tool for investigating disease mechanisms and developing therapeutic strategies. -
Glucocerebrosidase Inhibitor
Glucocerebrosidase-IN-2 is a potent inhibitor of glucocerebrosidase, a critical enzyme in lipid metabolism linked to Gaucher disease. This quinazoline derivative enhances glucocerebrosidase translocation to lysosomes in patient-derived cells, particularly those with the N370S mutation. It effectively inhibits the hydrolysis of substrates such as 4-methylumbelliferone β-D-glucopyranoside and fluorescent glycosylceramide in N370S mutant tissues, exhibiting an AC50 of 25.29 μM. Glucocerebrosidase-IN-2 is valuable for research focused on therapeutic approaches for Gaucher disease and related lysosomal storage disorders. -
Glycosidase Inhibitor
Glycosidase-IN-2 is a potent glycosidase inhibitor classified as an azasugar. This compound exhibits hypoglycemic activity, making it valuable in researching mechanisms related to glucose metabolism and diabetes management. Its ability to modulate glycosidase activity provides insights into carbohydrate processing and potential therapeutic applications for glycemic control. -
Beta-glucocerebrosidase Inhibitor
Glycosidase-IN-3 is a pyrimidine compound that acts as a selective inhibitor of beta-glucocerebrosidase. It has demonstrated significant biological activity relevant to the study of lysosomal storage disorders, particularly Gaucher's disease, as well as neurodegenerative conditions such as Parkinson's disease. This compound is suitable for use in research focused on these diseases and their underlying mechanisms. -
Antiallergic Agent
(3R,5S)-5'-Methoxyoctahydrocurcumin is a diarylheptanoid derived from Curcuma comosa, primarily targeting antiallergic mechanisms. This compound demonstrates significant activity in inhibiting β-hexosaminidase release and mast cell degranulation, making it a valuable tool in immunological studies. Its applications include research on various allergic conditions, such as asthma, where understanding the modulation of immune responses is critical. -
GCase Modulator
JZ-4109 is a potent β-Glucocerebrosidase (GCase) modulator, exhibiting an IC50 of 8 nM against wild-type recombinant GCase. This compound binds to an allosteric site at the GCase dimer interface, promoting dimerization and stabilizing both wild-type and GCase N370S mutant variants. JZ-4109 enhances GCase protein abundance, making it a valuable tool for research into Parkinson's disease and related conditions. -
Glycosidase Inhibitor
Nojirimycin is a nitrogen-containing sugar analog that functions as a glycosidase inhibitor. Its unique structure includes a ring nitrogen atom, which acts as an isostere of the oxygen atom in sugar rings, effectively inhibiting the activity of glycosidases. This compound is valuable in biochemical research for studying enzymatic functions and exploring metabolic pathways involving glycosidases. -
Glycosidase
Agarase is a glycosidase enzyme that catalyzes the hydrolysis of agar into oligosaccharides. This biochemical process is pivotal in the study of polysaccharide degradation and has applications in food science, molecular biology, and biotechnology. Agarase's ability to produce oligosaccharides from agar enhances research into carbohydrate metabolism and the development of agarose-based products. -
Human Glucocerebrosidase
Imiglucerase is a recombinant human glucocerebrosidase that catalyzes the hydrolysis of glucosylceramide into glucose and ceramide. This enzyme is primarily utilized in the research of type 1 (non-neuronopathic) and type 3 (chronic neuronopathic) Gaucher's disease. Imiglucerase facilitates studies on enzyme replacement therapy and its effects on cellular metabolism in Gaucher's disease pathophysiology.
