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MAGL Inhibitor

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Catalog No. A12747

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
JZL184 10mg A12747-10
JZL184 25mg A12747-25
JZL184 50mg A12747-50
JZL184 100mg A12747-100
JZL184 10mM * 1mL in DMSO A12747-10mM-D

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

JZL184 is a potent and selective monoacylglycerol lipase (MAGL) inhibitor. Blocks hydrolysis of the endocannabinoid 2-arachidonyl glycerol (2-AG) in vivo in the mouse brain (IC50 = 8 nM).


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Publications citing Adooq Products
JZL184 Citations (1)
  • Rea Pihlaja, .et al. The Anti-Inflammatory Effects of Lipoxygenase and Cyclo-Oxygenase Inhibitors in Inflammation-Induced Human Fetal Glia Cells and the A?? Degradation Capacity of Human Fetal Astrocytes in an Ex vivo Assay, Front Neurosci, 2017, 11: 299 PMID: 28611577

Chemical Information

Catalog Num A12747
Actions Inhibitor
M. Wt 520.49
Formula C27H24N2O9
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1101854-58-3
Synonyms JZL-184, JZL 184
SMILES C1CN(CCC1C(C2=CC3=C(C=C2)OCO3)(C4=CC5=C(C=C4)OCO5)O)C(=O)OC6=CC=C(C=C6)[N+](=O)[O-]

Biological Activity

JZL184 is a potent and selective monoacylglycerol lipase (MAGL) inhibitor. Blocks hydrolysis of the endocannabinoid 2-arachidonyl glycerol (2-AG) in vivo in the mouse brain (IC50 = 8 nM).


Solubility (25°C) * In vitro DMSO 100 mg/mL (192.12 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.21 mL 96.06 mL 192.13mL
0.5 mM 3.84 mL 19.21 mL 38.43 mL
1 mM 1.92 mL 9.61 mL 19.21 mL
5 mM 0.38 mL 1.92 mL 3.84 mL

*The above data is based on the productmolecular weight 520.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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