JZL184

Catalog No.: A12747

MAGL Inhibitor

JZL184

JZL184 Chemical Structure

CAS NO. 1101854-58-3

JZL184 is a potent and selective monoacylglycerol lipase (MAGL) inhibitor. Blocks hydrolysis of the endocannabinoid 2-arachidonyl glycerol (2-AG) in vivo in the mouse brain (IC50 = 8 nM).

Availability: In stock

Package Price Qty
10 mg
$40.00
25 mg
$80.00
50 mg
$130.00
100 mg
$200.00
10mM * 1mL in DMSO
$61.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Toshihiko Tsutsumi, .et al. Identification of human glycerophosphodiesterase 3 as an ecto phospholipase C that converts the G protein-coupled receptor 55 agonist lysophosphatidylinositol to bioactive monoacylglycerols in cultured mammalian cells, Biochim Biophys Acta Mol Cell Biol Lipids, 2020, Sep;1865(9):158761 PMID: 32629025
  • Rea Pihlaja, .et al. The Anti-Inflammatory Effects of Lipoxygenase and Cyclo-Oxygenase Inhibitors in Inflammation-Induced Human Fetal Glia Cells and the Aβ Degradation Capacity of Human Fetal Astrocytes in an Ex vivo Assay, Front Neurosci, 2017, 11: 299 PMID: 28611577

Biological Activity

JZL184 is a potent and selective monoacylglycerol lipase (MAGL) inhibitor. Blocks hydrolysis of the endocannabinoid 2-arachidonyl glycerol (2-AG) in vivo in the mouse brain (IC50 = 8 nM).
In vitro (25°C) DMSO 86 mg/mL (165.22 mM)
Water Insoluble
Ethanol Insoluble
In vivo 5%DMSO+40%PEG300+5%Tween80+ddH2O 2.3 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.21 mL 96.06 mL 192.13 mL
0.5 mM 3.84 mL 19.21 mL 38.43 mL
1 mM 1.92 mL 9.61 mL 19.21 mL
5 mM 0.38 mL 1.92 mL 3.84 mL

*The above data is based on the productmolecular weight 520.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12747
Actions Inhibitor
CAS No. 1101854-58-3
Formula C27H24N2O9
M. Wt 520.49
Solubility DMSO
Purity >98%
Synonyms JZL-184, JZL 184
SMILES C1CN(CCC1C(C2=CC3=C(C=C2)OCO3)(C4=CC5=C(C=C4)OCO5)O)C(=O)OC6=CC=C(C=C6)[N+](=O)[O-]
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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