JZL184

Catalog No.: A12747

MAGL Inhibitor

JZL184

JZL184 Chemical Structure

CAS NO. 1101854-58-3

JZL184 is a potent and selective monoacylglycerol lipase (MAGL) inhibitor. Blocks hydrolysis of the endocannabinoid 2-arachidonyl glycerol (2-AG) in vivo in the mouse brain (IC50 = 8 nM).

Availability: In stock

Package Price Qty
10 mg
$40.00
25 mg
$80.00
50 mg
$130.00
100 mg
$200.00
10mM * 1mL in DMSO
$61.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

JZL184 is a potent and selective monoacylglycerol lipase (MAGL) inhibitor. Blocks hydrolysis of the endocannabinoid 2-arachidonyl glycerol (2-AG) in vivo in the mouse brain (IC50 = 8 nM).
In vitro (25°C) DMSO 100 mg/mL (192.12 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.21 mL 96.06 mL 192.13 mL
0.5 mM 3.84 mL 19.21 mL 38.43 mL
1 mM 1.92 mL 9.61 mL 19.21 mL
5 mM 0.38 mL 1.92 mL 3.84 mL

*The above data is based on the productmolecular weight 520.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num A12747
Actions Inhibitor
M. Wt 520.49
Formula C27H24N2O9
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1101854-58-3
Synonyms JZL-184, JZL 184
SMILES C1CN(CCC1C(C2=CC3=C(C=C2)OCO3)(C4=CC5=C(C=C4)OCO5)O)C(=O)OC6=CC=C(C=C6)[N+](=O)[O-]

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