KCA-1490 is a dual inhibitor of phosphodiesterase 3 (PDE3) and phosphodiesterase 4 (PDE4), exhibiting IC50 values of 369 nM and 42 nM, respectively. This compound demonstrates significant bronchodilatory and anti-inflammatory effects, effectively suppressing histamine-induced bronchoconstriction in vivo. KCA-1490 is a valuable tool for research into asthma and chronic obstructive pulmonary disease (COPD) pathways and therapeutic strategies.
KCA-1490 is a dual inhibitor of phosphodiesterase 3 (PDE3) and phosphodiesterase 4 (PDE4), exhibiting IC50 values of 369 nM and 42 nM, respectively. This compound demonstrates significant bronchodilatory and anti-inflammatory effects, effectively suppressing histamine-induced bronchoconstriction in vivo. KCA-1490 is a valuable tool for research into asthma and chronic obstructive pulmonary disease (COPD) pathways and therapeutic strategies.
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