KCNT1-IN-3

Catalog No.: A68164
KCNT1 Inhibitor
KCNT1-IN-3 is a selective inhibitor of the potassium channel KCNT1, exhibiting an IC50 of 30 nM against wild-type human KCNT1. This compound is valuable for investigating the role of KCNT1 in epilepsy and related neurological conditions. Its potency allows for detailed studies into the modulation of ion channel activity and its implications in neuronal excitability.
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionKCNT1-IN-3 is a selective inhibitor of the potassium channel KCNT1, exhibiting an IC50 of 30 nM against wild-type human KCNT1. This compound is valuable for investigating the role of KCNT1 in epilepsy and related neurological conditions. Its potency allows for detailed studies into the modulation of ion channel activity and its implications in neuronal excitability.
Product Information
Catalog NumA68164
FormulaC16H15F3N6O3
Molecular Weight396.32
CAS Number2540501-85-5
SMILESCOC1=NC=CC(C2=NOC([C@@H](NC(C3=CC(C(F)(F)F)=NN3C)=O)C)=N2)=C1
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