Kenpaullone

Name: Kenpaullone
Brand: Adooq Bioscience
SKU: A11220
Rating: 100 (1 reviews)

Catalog No.: A11220

CDK inhibitor

Product Citations (1)

Kenpaullone Chemical Structure

CAS NO. 142273-20-9

Kenpaullone is a potent inhibitor of CDK1/cyclin B (IC₅₀ = 400 nM), CDK2/cyclin A (IC₅₀ = 680nM) , CDK5 (IC₅₀ = 850nM) and with much less effect other kinases.

Availability: In stock Shipped in 7-10 Days

Package	Price	Qty
10 mg	$90.00
50 mg	$380.00
100 mg	$650.00
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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable paper

Publications Citing Use of Adooq Kenpaullone

Katelyn M Green, .et al. High-throughput screening yields several small-molecule inhibitors of repeat-associated non-AUG translation, J Biol Chem, 2019, jbc.RA119.009951

Biological Activity

Kenpaullone is a potent inhibitor of CDK1/cyclin B (IC₅₀ = 400 nM), CDK2/cyclin A (IC₅₀ = 680nM) , CDK5 (IC₅₀ = 850nM) and with much less effect other kinases.

Targets

Target	Value
GSK-3β	IC50: 0.23μM
CDK1/CyclinB	IC50: 0.4μM
CDK2/CyclinA	IC50: 0.68μM
CDK5/p35	IC50: 0.85μM
CDK2/CyclinE	IC50: 7.5μM
ERK2	IC50: 9μM
c-Src	IC50: 15μM
CaseinKinase2	IC50: 20μM
ERK1	IC50: 20μM

Solubility *

In vitro (25°C)	DMSO	58 mg/mL (177.27 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+50% PEG 300+5% Tween 80+ddH2O	2.3 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	30.56 mL	152.81 mL	305.62 mL
0.5 mM	6.11 mL	30.56 mL	61.12 mL
1 mM	3.06 mL	15.28 mL	30.56 mL
5 mM	0.61 mL	3.06 mL	6.11 mL

*The above data is based on the productmolecular weight 327.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A11220
Actions	Inhibitor
CAS No.	142273-20-9
Formula	C16H11BrN2O
M. Wt	327.2
Purity	>98%
SMILES	C1C2=C(C3=CC=CC=C3NC1=O)NC4=C2C=C(C=C4)Br
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.