Customer Appreciation Sale.
15% off with promo code "APPRECIATION2023" on check out or purchase order

Kenpaullone

Catalog No.: A11220

CDK inhibitor

Kenpaullone

Kenpaullone Chemical Structure

CAS NO. 142273-20-9

Kenpaullone is a potent inhibitor of CDK1/cyclin B (IC₅₀ = 400 nM), CDK2/cyclin A (IC₅₀ = 680nM) , CDK5 (IC₅₀ = 850nM) and with much less effect other kinases.

Availability: In stock Shipped in 7-10 Days

Package Price Qty
10 mg
$90.00
50 mg
$380.00
100 mg
$650.00
Custom Size Get quote

Free Overnight Delivery on orders over $500

Next day delivery by 10:00 a.m. Order now.

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Katelyn M Green, .et al. High-throughput screening yields several small-molecule inhibitors of repeat-associated non-AUG translation, J Biol Chem, 2019, jbc.RA119.009951

Biological Activity

Kenpaullone is a potent inhibitor of CDK1/cyclin B (IC₅₀ = 400 nM), CDK2/cyclin A (IC₅₀ = 680nM) , CDK5 (IC₅₀ = 850nM) and with much less effect other kinases.
Targets
Target Value
GSK-3βIC50: 0.23μM
CDK1/CyclinBIC50: 0.4μM
CDK2/CyclinAIC50: 0.68μM
CDK5/p35IC50: 0.85μM
CDK2/CyclinEIC50: 7.5μM
ERK2IC50: 9μM
c-SrcIC50: 15μM
CaseinKinase2IC50: 20μM
ERK1IC50: 20μM
In vitro (25°C) DMSO 58 mg/mL (177.27 mM)
Water Insoluble
Ethanol Insoluble
In vivo 2% DMSO+50% PEG 300+5% Tween 80+ddH2O 2.3 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 30.56 mL 152.81 mL 305.62 mL
0.5 mM 6.11 mL 30.56 mL 61.12 mL
1 mM 3.06 mL 15.28 mL 30.56 mL
5 mM 0.61 mL 3.06 mL 6.11 mL

*The above data is based on the productmolecular weight 327.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11220
Actions Inhibitor
CAS No. 142273-20-9
Formula C16H11BrN2O
M. Wt 327.2
Purity >98%
SMILES C1C2=C(C3=CC=CC=C3NC1=O)NC4=C2C=C(C=C4)Br
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Tags

Product Tags

Use spaces to separate tags. Use single quotes (') for phrases.

Product Questions

Product Questions

No Questions
You may also be interested in the following product(s)
Keywords:buy Kenpaullone | Kenpaullone Supplier | purchase | cost | manufacturer | order | distributor | buy 142273-20-9| 142273-20-9 Supplier | purchase 142273-20-9 | 142273-20-9 cost | 142273-20-9 manufacturer | order 142273-20-9 | 142273-20-9 distributor
Rewards