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$0.00 - Katelyn M Green, .et al. High-throughput screening yields several small-molecule inhibitors of repeat-associated non-AUG translation, J Biol Chem, 2019, jbc.RA119.009951
Biological Activity
Kenpaullone is a potent inhibitor of CDK1/cyclin B (IC₅₀ = 400 nM), CDK2/cyclin A (IC₅₀ = 680nM) , CDK5 (IC₅₀ = 850nM) and with much less effect other kinases.
Targets
| Target | Value |
|---|---|
| GSK-3β | IC50: 0.23μM |
| CDK1/CyclinB | IC50: 0.4μM |
| CDK2/CyclinA | IC50: 0.68μM |
| CDK5/p35 | IC50: 0.85μM |
| CDK2/CyclinE | IC50: 7.5μM |
| ERK2 | IC50: 9μM |
| c-Src | IC50: 15μM |
| CaseinKinase2 | IC50: 20μM |
| ERK1 | IC50: 20μM |
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 30.56 mL | 152.81 mL | 305.62 mL |
| 0.5 mM | 6.11 mL | 30.56 mL | 61.12 mL |
| 1 mM | 3.06 mL | 15.28 mL | 30.56 mL |
| 5 mM | 0.61 mL | 3.06 mL | 6.11 mL |
*The above data is based on the productmolecular weight 327.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11220 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 327.2 |
| Formula | C16H11BrN2O |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 142273-20-9 |
| SMILES | C1C2=C(C3=CC=CC=C3NC1=O)NC4=C2C=C(C=C4)Br |
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