KGP591 is a potent inhibitor of tubulin polymerization with an IC50 of 0.57 µM. It effectively induces G2/M phase stagnation, inhibits cell migration, and disrupts microtubule structure and cell morphology in MDA-MB-231 human breast cancer cells. Additionally, KGP591 exhibits notable antitumor activity in an orthotopic kidney cancer model (RENCA), making it a valuable reagent for cancer research applications.
KGP591 is a potent inhibitor of tubulin polymerization with an IC50 of 0.57 µM. It effectively induces G2/M phase stagnation, inhibits cell migration, and disrupts microtubule structure and cell morphology in MDA-MB-231 human breast cancer cells. Additionally, KGP591 exhibits notable antitumor activity in an orthotopic kidney cancer model (RENCA), making it a valuable reagent for cancer research applications.
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