- Taniguchi R, .et al. Structural insights into ligand recognition by the lysophosphatidic acid receptor LPA6, Nature, 2017, Aug 17;548(7667):356-360 PMID: 28792932
- T. HASHIMOTO, .et al. Generalized pruritus in primary sclerosing cholangitis: implications of histamine release by lysophosphatidic acid., Br J Dermatol., 2015, Nov;173(5):1334-6 PMID: 26122943
Biological Activity
Ki16425 is a LPA receptor antagonist with selectivity for LPA1 and LPA3 and exhibits Ki values of 0.34, 6.5, and 0.93 μM for the human LPA1, LPA2, and LPA3 receptors, respectively.
In vitro (25°C) | DMSO | 85 mg/mL (178.96 mM) | |
Water | Insoluble | ||
Ethanol | 85 mg/mL (178.96 mM) | ||
In vivo | 5% DMSO+95% Corn oil | 28 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 21.05 mL | 105.26 mL | 210.53 mL |
0.5 mM | 4.21 mL | 21.05 mL | 42.11 mL |
1 mM | 2.11 mL | 10.53 mL | 21.05 mL |
5 mM | 0.42 mL | 2.11 mL | 4.21 mL |
*The above data is based on the productmolecular weight 475.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A10501 |
---|---|
Actions | Antagonist |
CAS No. | 355025-24-0 |
Formula | C23H23ClN2O5S |
M. Wt | 475.0 |
Purity | >98% |
Synonyms | Ki 16425, Ki-16425 |
SMILES | CC1=NOC(=C1NC(=O)OC(C)C2=CC=CC=C2Cl)C3=CC=C(C=C3)CSCCC(=O)O |
Storage | Store lyophilized at -20ºC, keep desiccated. |
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