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Ki16425

Catalog No.: A10501

LPA Receptor Antagonist

Ki16425

Ki16425 Chemical Structure

CAS NO. 355025-24-0

Ki16425 is a LPA receptor antagonist with selectivity for LPA1 and LPA3 and exhibits Ki values of 0.34, 6.5, and 0.93 μM for the human LPA1, LPA2, and LPA3 receptors, respectively.

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Package Price Qty
5 mg

Regular Price: $50.00

Special Price $40.00

10 mg

Regular Price: $90.00

Special Price $72.00

50 mg

Regular Price: $360.00

Special Price $288.00

100 mg

Regular Price: $450.00

Special Price $360.00

10mM * 1mL in DMSO

Regular Price: $107.00

Special Price $85.60

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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Maria F Fernandes, .et al. Glucagon-like Peptide-1 Secretion Is Inhibited by Lysophosphatidic Acid, Int J Mol Sci, 2022, Apr 9;23(8):4163 PMID: 35456981
  • Rieko Suenaga, .et al. Lateral access mechanism of LPA receptor probed by molecular dynamics simulation, PLoS One, 2022, Feb 3;17(2):e0263296 PMID: 35113924
  • Inoue A, .et al. Illuminating G-Protein-Coupling Selectivity of GPCRs, Cell, 2019, Jun 13;177(7):1933-1947 PMID: 31160049
  • Taniguchi R, .et al. Structural insights into ligand recognition by the lysophosphatidic acid receptor LPA6, Nature, 2017, Aug 17;548(7667):356-360 PMID: 28792932
  • T. HASHIMOTO, .et al. Generalized pruritus in primary sclerosing cholangitis: implications of histamine release by lysophosphatidic acid., Br J Dermatol., 2015, Nov;173(5):1334-6 PMID: 26122943

Biological Activity

Ki16425 is a LPA receptor antagonist with selectivity for LPA1 and LPA3 and exhibits Ki values of 0.34, 6.5, and 0.93 μM for the human LPA1, LPA2, and LPA3 receptors, respectively.
In vitro (25°C) DMSO 85 mg/mL (178.96 mM)
Water Insoluble
Ethanol 85 mg/mL (178.96 mM)
In vivo 5% DMSO+95% Corn oil 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.05 mL 105.26 mL 210.53 mL
0.5 mM 4.21 mL 21.05 mL 42.11 mL
1 mM 2.11 mL 10.53 mL 21.05 mL
5 mM 0.42 mL 2.11 mL 4.21 mL

*The above data is based on the productmolecular weight 475.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10501
Actions Antagonist
CAS No. 355025-24-0
Formula C23H23ClN2O5S
M. Wt 475.0
Purity >98%
Synonyms Ki 16425, Ki-16425
SMILES CC1=NOC(=C1NC(=O)OC(C)C2=CC=CC=C2Cl)C3=CC=C(C=C3)CSCCC(=O)O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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