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- Taniguchi R, .et al. Structural insights into ligand recognition by the lysophosphatidic acid receptor LPA6, Nature, 2017, Aug 17;548(7667):356-360 PMID: 28792932
- T. HASHIMOTO, .et al. Generalized pruritus in primary sclerosing cholangitis: implications of histamine release by lysophosphatidic acid., Br J Dermatol., 2015, Nov;173(5):1334-6 PMID: 26122943
|Storage||at -20°C 3 years Powder|
|Synonyms||Ki 16425, Ki-16425|
|Chemical Name||3-[[[4-[4-[[[1-(2-chlorophenyl)ethoxy]carbonyl]amino]-3-methyl-5-isoxazoly]phenyl]methyl]thio]-propanoic acid|
|Ki16425 is a LPA receptor antagonist with selectivity for LPA1 and LPA3 and exhibits Ki values of 0.34, 6.5, and 0.93 ?M for the human LPA1, LPA2, and LPA3 receptors, respectively.|
|Solubility (25°C) *||In vitro||DMSO||95 mg/mL (200.01 mM)|
|Water||<1 mg/mL (<1 mM)|
|Ethanol||95 mg/mL (200.01 mM)|
|In vivo||5% DMSO/95% Corn oil||30 mg/mL|
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||21.05 mL||105.26 mL||210.53mL|
|0.5 mM||4.21 mL||21.05 mL||42.11 mL|
|1 mM||2.11 mL||10.53 mL||21.05 mL|
|5 mM||0.42 mL||2.11 mL||4.21 mL|
*The above data is based on the productmolecular weight 475.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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