KMR-206 is a selective inhibitor of PARP7, demonstrating an IC50 of 13.7 nM. This compound enhances the activation of STAT1 and phosphorylated STAT1, thereby promoting type I interferon signaling through STING degradation. KMR-206 exhibits notable anticancer activity, particularly against lung adenocarcinoma, and serves as a valuable tool for investigating its effects in colon cancer research.
KMR-206 is a selective inhibitor of PARP7, demonstrating an IC50 of 13.7 nM. This compound enhances the activation of STAT1 and phosphorylated STAT1, thereby promoting type I interferon signaling through STING degradation. KMR-206 exhibits notable anticancer activity, particularly against lung adenocarcinoma, and serves as a valuable tool for investigating its effects in colon cancer research.
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