KU 0060648

Catalog No.: A13224

DNA-PK inhibitor

KU 0060648 Chemical Structure

CAS NO. 881375-00-4

KU0060648 is a potent and selective inhibitor of DNA-dependent protein kinase (DNA-PK), (IC50 = 8.6 nM); with 20-1000 fold selectivity for DNA-PK over other PIKKs and a panel of 60 kinases. KU-0060648 enhances HDR efficiency and attenuates NHEJ frequency.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $100.00

Special Price $80.00

10 mg

Regular Price: $180.00

Special Price $144.00

25 mg

Regular Price: $350.00

Special Price $280.00

50 mg

Regular Price: $600.00

Special Price $480.00

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

KU0060648 is a potent and selective inhibitor of DNA-dependent protein kinase (DNA-PK), (IC50 = 8.6 nM); with 20-1000 fold selectivity for DNA-PK over other PIKKs and a panel of 60 kinases. KU-0060648 enhances HDR efficiency and attenuates NHEJ frequency.
In vitro (25°C) DMSO <1 mg/mL (<1 mM)
Water 0.4 mg/mL (0.68 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 20 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 14.45 mL 72.24 mL 144.49 mL
0.5 mM 2.89 mL 14.45 mL 28.9 mL
1 mM 1.44 mL 7.22 mL 14.45 mL
5 mM 0.29 mL 1.44 mL 2.89 mL

*The above data is based on the productmolecular weight 692.1. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13224
Actions Inhibitor
M. Wt 692.1
Formula C33H34N4O4S.3HCl
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 881375-00-4
Synonyms KU0060648, KU-0060648
SMILES CCN1CCN(CC1)CC(=O)NC2=C3C4=CC=CC=C4SC3=C(C=C2)C5=CC=CC6=C5OC(=CC6=O)N7CCOCC7

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