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|Storage||at -20°C 3 years Powder|
|Chemical Name||2-(4-Ethylpiperazin-1-yl)-N-(4-(2-morpholino-4-oxo-4H-chromen-8-yl)dibenzo[b,d]thiophen-1-yl)acetamide trihydrochloride|
|KU0060648 is a potent and selective inhibitor of DNA-dependent protein kinase (DNA-PK), (IC50 = 8.6 nM); with 20-1000 fold selectivity for DNA-PK over other PIKKs and a panel of 60 kinases. KU-0060648 enhances HDR efficiency and attenuates NHEJ frequency.|
|Solubility (25°C) *||In vitro||DMSO||<1 mg/mL (<1 mM)|
|Water||0.4 mg/mL (0.68 mM)|
|Ethanol||<1 mg/mL (<1 mM)|
|In vivo||30% propylene glycol, 5% Tween 80, 65% D5W||20 mg/mL|
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||14.45 mL||72.24 mL||144.49mL|
|0.5 mM||2.89 mL||14.45 mL||28.9 mL|
|1 mM||1.44 mL||7.22 mL||14.45 mL|
|5 mM||0.29 mL||1.44 mL||2.89 mL|
*The above data is based on the productmolecular weight 692.1. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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