Kv7.2/Kv7.3 agonist 1 is a potent orally active agonist targeting the KV7.2/7.3 channels (KCNQ2/3), exhibiting an EC50 value of 1.03 μM. This compound demonstrates significant analgesic effects in both the chronic constriction injury (CCI) model and the Streptozotocin-induced diabetic peripheral neuropathic pain (DPNP) model, with effective doses (ED50) of 12.02 mg/kg and 9.63 mg/kg, respectively. It serves as a valuable tool for research into pain management and neurological conditions associated with Kv7 channel modulation.
Kv7.2/Kv7.3 agonist 1 is a potent orally active agonist targeting the KV7.2/7.3 channels (KCNQ2/3), exhibiting an EC50 value of 1.03 μM. This compound demonstrates significant analgesic effects in both the chronic constriction injury (CCI) model and the Streptozotocin-induced diabetic peripheral neuropathic pain (DPNP) model, with effective doses (ED50) of 12.02 mg/kg and 9.63 mg/kg, respectively. It serves as a valuable tool for research into pain management and neurological conditions associated with Kv7 channel modulation.
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